Actions of α2 adrenoceptor ligands at α2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for α2A adrenoceptors

Yohimbine induced anxiety and increased noradrenergic function in humans: Effects of diazepam and clonidine

1983 • 350 citations

Assessment of the role of α₂‐adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice

1997 • 291 citations

Receptor reserve for 5-hydroxytryptamine1A-mediated inhibition of serotonin synthesis: possible relationship to anxiolytic properties of 5-hydroxytryptamine1A agonists.

1990 • 227 citations

Site-directed mutagenesis of alpha 2A-adrenergic receptors: identification of amino acids involved in ligand binding and receptor activation by agonists.

1991 • 221 citations

Simultaneous quantification of serotonin, dopamine and noradrenaline levels in single frontal cortex dialysates of freely-moving rats reveals a complex pattern of reciprocal auto- and heteroreceptor-mediated control of release

1998 • 202 citations

An evaluation of the elevated plus-maze test using the novel anxiolytic buspirone

1989 • 192 citations

Shock-induced ultrasonic vocalization in young adult rats: a model for testing putative anti-anxiety drugs

1993 • 178 citations

Multiple alpha-2 adrenergic receptor subtypes. II. Evidence for a role of rat R alpha-2A adrenergic receptors in the control of nociception, motor behavior and hippocampal synthesis of noradrenaline.

1994 • 132 citations

Yohimbine as a serotonergic agent: evidence from receptor binding and drug discrimination.

1992 • 130 citations

α₂‐Adrenergic Receptor Blockade Markedly Potentiates Duloxetine‐ and Fluoxetine‐Induced Increases in Noradrenaline, Dopamine, and Serotonin Levels in the Frontal Cortex of Freely Moving Rats

1997 • 101 citations

Presynaptic ?2-autoreceptors in brain cortex: ?2D in the rat and ?2A in the rabbit

1993 • 94 citations

Peripheral hyperalgesia in experimental neuropathy: mediation by α2-adrenoreceptors on post-ganglionic sympathetic terminals

1995 • 88 citations

Agonist and Inverse Agonist Efficacy at Human Recombinant Serotonin 5-HT 1A Receptors as a Function of Receptor:G-protein Stoichiometry

1997 • 87 citations

Dexmedetomidine, a novel alpha2-adrenergic agonist. A review of its pharmacodynamic characteristics

1993 • 86 citations

Evaluation of the effects of a specific α2-adrenoceptor antagonist, atipamezole, on α1- and α2-adrenoceptor subtype binding, brain neurochemistry and behaviour in comparison with yohimbine

1997 • 83 citations

The Role of Descending Noradrenergic and Serotoninergic Pathways in the Modulation of Nociception: Focus on Receptor Multiplicity

1997 • 70 citations

Molecular cloning, sequencing and expression of an ?2-adrenergic receptor complementary DNA from rat brain

1990 • 68 citations

Characterization of subtypes of alpha-2 adrenoceptors in the human brain.

1993 • 67 citations

Diverse tissue expression of rat alpha 2-adrenergic receptor genes.

1993 • 65 citations

α₂‐Adrenoceptor Subtypes Identified by [³H]RX821002 Binding in the Human Brain: The Agonist Guanoxabenz Does Not Discriminate Different Forms of the Predominant α_2A Subtype

1994 • 62 citations

Species orthologs of the alpha-2A adrenergic receptor: the pharmacological properties of the bovine and rat receptors differ from the human and porcine receptors.

1994 • 61 citations

Anxiolytic-like effects of yohimbine in the murine plus-maze: strain independence and evidence against α2-adrenoceptor mediation

1995 • 57 citations

α2-Adrenoceptor subtypes in the human brain: a pharmacological delineation of [3H]RX-821002 binding to membranes and tissue sections

1996 • 51 citations

Partial agonist effect of 2-[2-(1,4-Benzodioxanyl)]-2-imidazoline (RX 781094) at presynaptic ?2-adrenoceptors in rabbit ear artery

1983 • 49 citations

Release-inhibiting ?2-adrenoceptors at serotonergic axons in rat and rabbit brain cortex: evidence for pharmacological identity with ?2-autoreceptors

1994 • 49 citations

The Second Intracellular Loop of the α2-Adrenergic Receptors Determines Subtype-specific Coupling to cAMP Production

1997 • 48 citations

Mechanism of action of anxiolytic drugs

1987 • 44 citations

The α2-adrenoceptor antagonist idazoxan is an agonist at 5-HT1A autoreceptors modulating serotonin synthesis in the rat brain in vivo

1996 • 38 citations

Comparative behavioural profiles of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) in the murine elevated plus-maze

1997 • 37 citations

Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT1A receptors

1993 • 35 citations

Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine—II. Effects of acute administration of 1-PP and long-term adminstration of tandospirone on noradrenergic neurotransmission

1991 • 32 citations

1-(2-Pyrimidinyl)-piperazine may alter the effects of the 5-HT1A agonists in the learned helplessness paradigm in rats

1991 • 29 citations

Subclassification and nomenclature of α1- and α2-adrenoceptors

1996 • 28 citations

The pharmacology of fluparoxan: a selective α₂‐adrenoceptor antagonist

1991 • 26 citations

Oxymetazoline inhibits adenylate cyclase by activation of serotonin-1 receptors in the OK cell, an established renal epithelial cell line.

1988 • 21 citations

Adjunctive yohimbine for treatment in refractory depression

1993 • 15 citations

Evaluation of the alpha 2‐adrenoceptor blocking properties of buspirone and ipsapirone in healthy subjects. Relationship with the plasma concentration of the common metabolite 1‐(2‐pyrimidinyl)‐piperazine.

1995 • 13 citations

Inhibitory effect of idazoxan on forskolin-stimulated adenylate cyclase activity through 5-hydroxytryptamine1A receptors.

1994 • 12 citations

Effect of RX 821002 at 5‐HT_1A‐receptors in rabbit spinal cord in vivo

1998 • 12 citations

The azapirone metabolite 1-(2-pyrimidinyl)piperazine depresses excitatory synaptic transmission in the hippocampus of the alert rat via 5-HT1A receptors

1995 • 12 citations

α2-Adrenergic Mechanisms of Analgesia: Strategies for Improving Their Therapeutic Window and Identification of the Novel, Potent α2-Adrenergic Receptor Agonist, S 18616

1997 • 11 citations

Anxiolytic-like effects of alpha-2-adrenoceptor agonists on conflict behavior in the rat: Pre- versus postsynaptic receptor mechanisms

1992 • 10 citations

Functional evidence that ?2A-adrenoceptors are responsible for antilipolysis in human abdominal fat cells

1994 • 8 citations

P.1.047 Yohimbine is a potent, partial agonist at rat and cloned, human serotonin1A receptors: A comparison to buspirone and its metabolite, 1-pyrimidinylpiperazine

1997 • 7 citations

The antidepressant-like activity of idazoxan, yohimbine and clenbuterol

1995 • 2 citations