Revising B Cell Receptors

Receptor editing in self-reactive bone marrow B cells.

1993 • 1,026 citations

Receptor editing: an approach by autoreactive B cells to escape tolerance.

1993 • 920 citations

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

1984 • 545 citations

B lymphocytes may escape tolerance by revising their antigen receptors.

1993 • 425 citations

The Complete Nucleotide Sequence of the Human Immunoglobulin Heavy Chain Variable Region Locus

1998 • 401 citations

Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion

1999 • 372 citations

Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma

1986 • 332 citations

A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production

1986 • 331 citations

Immunoglobulin heavy chain gene replacement: A mechanism of receptor editing

1995 • 313 citations

V(D)J Recombinase Activity in a Subset of Germinal Center B Lymphocytes

1997 • 284 citations

Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus

1982 • 278 citations

Neoteny in Lymphocytes: Rag1 and Rag2 Expression in Germinal Center B Cells

1996 • 272 citations

Developmental Regulation of B Lymphocyte Immune Tolerance Compartmentalizes Clonal Selection from Receptor Selection

1998 • 234 citations

Analysis of Heavy and Light Chain Pairings Indicates that Receptor Editing Shapes the Human Antibody Repertoire

1999 • 220 citations

Reexpression of RAG-1 and RAG-2 Genes in Activated Mature Mouse B cells

1996 • 219 citations

One-megabase sequence analysis of the human immunoglobulin lambda gene locus.

1997 • 209 citations

Recent Advances in Understanding V(D)J Recombination

1997 • 196 citations

BCR Ligation Induces Receptor Editing in IgM+IgD− Bone Marrow B Cells In Vitro

1997 • 178 citations

Receptor Revision of Immunoglobulin Heavy Chain Variable Region Genes in Normal Human B Lymphocytes

2000 • 159 citations

Antigen Receptor Engagement Turns off the V(D)J Recombination Machinery in Human Tonsil B Cells

1998 • 138 citations

Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci.

1993 • 135 citations

Cutting Edge: Absence of Expression of RAG1 in Peritoneal B-1 Cells Detected by Knocking into RAG1 Locus with Green Fluorescent Protein Gene

1999 • 133 citations

Enforced Bcl-2 Expression Inhibits Antigen-mediated Clonal Elimination of Peripheral B Cells in an Antigen Dose–dependent Manner and Promotes Receptor Editing in Autoreactive, Immature B Cells

1997 • 132 citations

Somatic Mutation and Light Chain Rearrangement Generate Autoimmunity in Anti–Single-Stranded DNA Transgenic Mrl/lpr Mice

1999 • 122 citations

Frequent Aberrant Immunoglobulin Gene Rearrangements in Pro-B Cells Revealed by a bcl-x Transgene

1996 • 120 citations

The organization of the mouse Igh-V locus. Dispersion, interspersion, and the evolution of VH gene family clusters.

1988 • 116 citations

V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling

1998 • 114 citations

DNA between variable and joining gene segments of immunoglobulin kappa light chain is frequently retained in cells that rearrange the kappa locus.

1982 • 113 citations

Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus

1993 • 112 citations

Immunoglobulin kappa chain receptor editing in systemic lupus erythematosus.

1998 • 111 citations

V(D)J recombination and the cell cycle

1995 • 98 citations

Distinctive characteristics of germinal center B cells

1997 • 96 citations

Expression of Recombination Activating Genes in Germinal Center B Cells: Involvement of Interleukin 7 (IL-7) and the IL-7 Receptor

1998 • 75 citations

Characterization of a novel cell-surface molecule expressed on subpopulations of activated T and B cells.

1993 • 74 citations

Secondary V(D)J recombination in B-1 cells

1999 • 68 citations

Atypical VH-D-JH Rearrangements in Newborn Autoimmune MRL Mice

1999 • 60 citations

RAG2is regulated differentially in B and T cells by elements 5′ of the promoter

1999 • 53 citations

Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus

1994 • 51 citations

Analysis of VH gene replacement events in a B cell lymphoma.

1989 • 48 citations

Models for Antigen Receptor Gene Rearrangement. I. Biased Receptor Editing in B Cells: Implications for Allelic Exclusion

1999 • 39 citations

The human immunoglobulin κ genes

1995 • 36 citations