PU.1/Spi-B Regulation of c-rel Is Essential for Mature B Cell Survival

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages

1994 • 1,506 citations

Requirement for NF-κB in osteoclast and B-cell development

1997 • 994 citations

The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene

1990 • 993 citations

Osteopetrosis in mice lacking NF-κB1 and NF-κB2

1997 • 988 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

1991 • 876 citations

The Rel/NF-κB Family Directly Activates Expression of the Apoptosis Inhibitor Bcl-x_L

2000 • 747 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNFalpha -induced apoptosis

1999 • 721 citations

NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1999 • 526 citations

GENETIC ANALYSIS OF B CELL ANTIGEN RECEPTOR SIGNALING

1999 • 432 citations

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

1999 • 410 citations

Interaction of murine ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif.

1992 • 381 citations

PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3' enhancer activity.

1992 • 362 citations

Genetic approaches in mice to understand Rel/NF-κB and IκB function: transgenics and knockouts

1999 • 322 citations

The ets gene family

1992 • 308 citations

A new pattern for helix–turn–helix recognition revealed by the PU.l ETS–domain–DNA complex

1996 • 307 citations

Sequential Induction of NF-κB/Rel Family Proteins during B-Cell Terminal Differentiation

1994 • 275 citations

Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage

1999 • 259 citations

B Lymphocytes Differentially Use the Rel and Nuclear Factor κB1 (NF-κB1) Transcription Factors to Regulate Cell Cycle Progression and Apoptosis in Quiescent and Mitogen-activated Cells

1998 • 250 citations

High levels of c-rel expression are associated with programmed cell death in the developing avian embryo and in bone marrow cells in vitro

1993 • 231 citations

Regulation of lymphoid-specific immunoglobulin mu heavy chain gene enhancer by ETS-domain proteins

1993 • 228 citations

The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

2000 • 226 citations

Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B

1995 • 222 citations

Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1

1993 • 211 citations

Failure of Lymphopoiesis after Adoptive Transfer of NF-κB–Deficient Fetal Liver Cells

1997 • 193 citations

Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus.

1990 • 192 citations

PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer.

1993 • 188 citations

Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B

1997 • 172 citations

Transcription Factors in Lymphocyte Development— T and B Cells Get Together

1999 • 169 citations

Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1.

1992 • 160 citations

The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects

1999 • 144 citations

An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of ETS family factors to promoter sequences of the mb-1 gene.

1992 • 143 citations

Sequential induction of NF-kappa B/Rel family proteins during B-cell terminal differentiation.

1994 • 137 citations

c-Rel is essential for B lymphocyte survival and cell cycle progression

1998 • 131 citations

Ets-related protein PU.1 regulates expression of the immunoglobulin J-chain gene through a novel Ets-binding element.

1993 • 129 citations

Qualitative changes in the subunit composition of kappa B-binding complexes during murine B-cell differentiation.

1994 • 125 citations

Functional characterization of the developmentally controlled immunoglobulin kappa 3' enhancer: regulation by Id, a repressor of helix-loop-helix transcription factors.

1991 • 123 citations

Constitutive and inducible Rel/NF-kappa B activities in mouse thymus and spleen.

1994 • 120 citations

The Ets protein Spi-B is expressed exclusively in B cells and T cells during development.

1996 • 114 citations

PU.1 and Spi-B Are Required for Normal B Cell Receptor–Mediated Signal Transduction

1999 • 111 citations

DNA binding specificities of Spi-1/PU.1 and Spi-B transcription factors and identification of a Spi-1/Spi-B binding site in the c-fes/c-fps promoter.

1995 • 111 citations

The subunit composition of NF-kappa B complexes changes during B-cell development.

1994 • 93 citations

Analysis of the Bruton's tyrosine kinase gene promoter reveals critical PU.1 and SP1 sites

1996 • 69 citations

Multiple motifs regulate the B-cell-specific promoter of the B29 gene.

1993 • 61 citations

rel/NF-kappa B nuclear complexes that bind kB sites in the murine c-rel promoter are required for constitutive c-rel transcription in B-cells.

1993 • 55 citations

Spi-C, a Novel Ets Protein That Is Temporally Regulated during B Lymphocyte Development

1999 • 52 citations

SPI-B Activates Transcription via a Unique Proline, Serine, and Threonine Domain and Exhibits DNA Binding Affinity Differences from PU.1

1999 • 45 citations

The Ets Factors PU.1 and Spi-B Regulate the Transcriptionin Vivo of P2Y10, a Lymphoid Restricted Heptahelical Receptor

1999 • 43 citations

The murine c-rel proto-oncogene encodes two mRNAs the expression of which is modulated by lymphoid stimuli.

1990 • 36 citations

Induction of nuclear factor-kappa B during primary B cell differentiation.

1998 • 35 citations

Induction of Nuclear Factor-κB During Primary B Cell Differentiation

1998 • 31 citations

Regulation of Mouse CD72 Gene Expression During B Lymphocyte Development

1998 • 26 citations

Functional Significance of Alternate Phosphorylation in Sendai Virus P Protein

2000 • 19 citations

Cloning and transcription factor-binding sites of the human c-rel proto-oncogene promoter

1996 • 15 citations

Differential interaction of nuclear factors with the leukocyte-specific pp52 promoter in B and T cells.

1997 • 11 citations