Gelsolin Deficiency Blocks Podosome Assembly and Produces Increased Bone Mass and Strength

Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee

1987 • 4,980 citations

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

Bone Histomorphometry : Standardization of Nomenclature, Symbols, and Units

1987 • 3,281 citations

Effect of Oral Alendronate on Bone Mineral Density and the Incidence of Fractures in Postmenopausal Osteoporosis

1995 • 2,293 citations

Principles of Bone Biology

1997 • 1,367 citations

Alendronate for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis

1998 • 1,256 citations

Osteoclastic Bone Resorption by a Polarized Vacuolar Proton Pump

1989 • 864 citations

Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate

1987 • 624 citations

Nonmuscle Actin-Binding Proteins

1985 • 589 citations

Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice.

1992 • 557 citations

Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin.

1996 • 555 citations

From signal to pseudopod

1989 • 460 citations

Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin

1995 • 437 citations

Identification and characterization of a novel cytoskeleton-associated pp60src substrate.

1991 • 435 citations

Functions of gelsolin: motility, signaling, apoptosis, cancer

1999 • 373 citations

Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis

1996 • 358 citations

Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence.

1996 • 345 citations

Cell-substratum interaction of cultured avian osteoclasts is mediated by specific adhesion structures.

1984 • 324 citations

Enhanced Motility in NIH 3T3 Fibroblasts That Overexpress Gelsolin

1991 • 321 citations

Dephosphorylation of osteopontin and bone sialoprotein by osteoclastic tartrate-resistant acid phosphatase. Modulation of osteoclast adhesion in vitro.

1994 • 306 citations

Rescue of osteoclast function by transgenic expression of kinase-deficient Src insrc−/− mutant mice

1997 • 270 citations

Gelsolin is a downstream effector of rac for fibroblast motility

1998 • 267 citations

Signaling to Actin Dynamics

1999 • 260 citations

Polyphosphoinositide micelles and polyphosphoinositide-containing vesicles dissociate endogenous gelsolin-actin complexes and promote actin assembly from the fast-growing end of actin filaments blocked by gelsolin.

1987 • 256 citations

Kinetics of the osteoclast cytoskeleton during the resorption cycle in vitro

1991 • 245 citations

Gelsolin: Calcium‐ and polyphosphoinositide‐regulated actin‐ modulating protein

1987 • 228 citations

Rous sarcoma virus-transformed fibroblasts and cells of monocytic origin display a peculiar dot-like organization of cytoskeletal proteins involved in microfilament-membrane interactions*1

1987 • 216 citations

Control of Actin Assembly at Filament Ends

1995 • 202 citations

Immunocytochemical distribution of extracellular matrix receptors in human osteoclasts: A β3 integrin is colocalized with vinculin and talin in the podosomes of osteoclastoma giant cells

1989 • 199 citations

Suppression of vinculin expression by antisense transfection confers changes in cell morphology, motility, and anchorage-dependent growth of 3T3 cells

1993 • 199 citations

Integrin, A Transmembrane Glycoprotein Complex Mediating Cell-Substratum Adhesion

1987 • 176 citations

F-actin capping proteins

1993 • 175 citations

The small gtp-binding protein, RHO p21, is involved in bone resorption by regulating cytoskeletal organization in osteoclasts

1995 • 169 citations

A band of F-actin containing podosomes is involved in bone resorption by osteoclasts

1990 • 155 citations

Osteoclastic bone resorption: In vitro analysis of the rate of resorption and migration of individual osteoclasts

1988 • 155 citations

Overexpression of vinculin suppresses cell motility in BALB/c 3T3 cells

1992 • 149 citations

Delayed Retraction of Filopodia in Gelsolin Null Mice

1997 • 145 citations

Clear zone in osteoclast function: role of podosomes in regulation of bone-resorbing activity

1991 • 142 citations

Rescue of the mutant phenotype by reexpression of full-length vinculin in null F9 cells; effects on cell locomotion by domain deleted vinculin

1998 • 131 citations

The Effects of Androgen Deficiency on Murine Bone Remodeling and Bone Mineral Density Are Mediated via Cells of the Osteoblastic Lineage*

1997 • 125 citations

Downregulation of calcitonin receptor mRNA expression by calcitonin during human osteoclast-like cell differentiation.

1995 • 123 citations

Identification and Characterization of a Novel Cytoskeleton-Associated pp60^src Substrate

1991 • 113 citations

Osteoclast biology: Lessons from mammalian mutations

1989 • 111 citations

Osteopontin stimulates gelsolin-associated phosphoinositide levels and phosphatidylinositol triphosphate-hydroxyl kinase.

1996 • 109 citations

Polyphosphoinositides Inhibit the Interaction of Vinculin with Actin Filaments

1999 • 104 citations

Type‐I collagen mutation compromises the post‐yield behavior of Mov13 long bone

1996 • 102 citations

A Dictyostelium mutant deficient in severin, an F-actin fragmenting protein, shows normal motility and chemotaxis.

1989 • 100 citations

c-Src Is Required for Stimulation of Gelsolin-associated Phosphatidylinositol 3-Kinase

1998 • 99 citations

Immunologic evidence that vacuolar H+ ATPases with heterogeneous forms of Mr = 31,000 subunit have different membrane distributions in mammalian kidney.

1992 • 98 citations

Adhesion patterns and cytoskeleton of rabbit osteoclasts on bone slices and glass

1988 • 87 citations

Spatial organization of microfilaments and vitronectin receptor,αvβ3, in osteoclasts: A study using confocal laser scanning microscopy

1993 • 86 citations

Dependence of Fibroblast Migration on Actin Severing Activity of Gelsolin

1996 • 85 citations

Isolation and Characterization of Highly Enriched, Prefusion Mouse Osteoclastic Cells

1995 • 85 citations

Phosphatidylinositol 3-Kinase Association with the Osteoclast Cytoskeleton, and Its Involvement in Osteoclast Attachment and Spreading

1997 • 82 citations

Gelsolin modulation in epithelial and stromal cells of mammary carcinoma.

1989 • 74 citations

Predominant induction of gelsolin and actin-binding protein during myeloid differentiation.

1988 • 70 citations

Osteoclasts and monocytes have similar cytoskeletal structures and adhesion property in vitro.

1983 • 67 citations

Structural relationships of actin-binding proteins

1992 • 64 citations

Cellular distribution and regulation of NHE-1 isoform of the Na-H exchanger in the avian osteoclast

1996 • 63 citations

Phosphatidylinositol-3 kinase is involved in ruffled border formation in osteoclasts

1997 • 60 citations

Osteopontin activation of c-src in human melanoma cells requires the cytoplasmic domain of the integrin alpha v-subunit.

1996 • 54 citations

The effect of fluoride on the patterns of adherence of osteoclasts cultured on and resorbing dentine: a 3-D assessment of vinculin-labelled cells using confocal optical microscopy

1989 • 42 citations

Enrichment of generated murine osteoclasts

1994 • 41 citations

Chick osteocyte-derived protein inhibits osteoclastic bone resorption

1997 • 33 citations

Modulation of gelsolin content in rat aortic smooth muscle cells during development, experimental intimal thickening and culture

1990 • 25 citations

Actin cytoskeleton: Setting the pace of cell movement

1995 • 24 citations

Calcium and Polyphosphoinositide Regulation of Actin Network Structure by Gelsolin

1989 • 7 citations