Inhibition of fibroblast growth factors

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

Angiogenic Factors

1987 • 3,702 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Angiogenesis.

1992 • 2,581 citations

THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINS

1989 • 1,948 citations

Tumor Angiogenesis: A New Significant and Independent Prognostic Indicator in Early-Stage Breast Carcinoma

1992 • 1,799 citations

Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma.

1993 • 1,646 citations

Structural Characterization and Biological Functions of Fibroblast Growth Factor

1987 • 1,299 citations

The implications of angiogenesis for the biology and therapy of cancer metastasis

1994 • 1,120 citations

Simple RNA enzymes with new and highly specific endoribonuclease activities

1988 • 1,118 citations

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

1987 • 1,045 citations

A small catalytic oligoribonucleotide

1987 • 938 citations

Heparin Affinity: Purification of a Tumor-Derived Capillary Endothelial Cell Growth Factor

1984 • 937 citations

Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

1986 • 856 citations

Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer

1992 • 822 citations

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation.

1988 • 810 citations

Relation of neovascularisation to metastasis of non-small-cell lung cancer

1992 • 780 citations

Gene inhibition using antisense oligodeoxynucleotides

1994 • 746 citations

How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes memorial Award lecture.

1986 • 744 citations

Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF.

1985 • 710 citations

Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells.

1994 • 702 citations

Growth factors in development, transformation, and tumorigenesis

1991 • 695 citations

Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules

1989 • 597 citations

Microvessel quantitation and prognosis in invasive breast carcinoma

1992 • 566 citations

The ins and outs of fibroblast growth factors

1994 • 535 citations

An Essential Heparin-Binding Domain in the Fibroblast Growth Factor Receptor Kinase

1993 • 520 citations

Elevated Levels of an Angiogenic Peptide, Basic Fibroblast Growth Factor, in the Urine of Patients With a Wide Spectrum of Cancers

1994 • 478 citations

SMALL CATALYTIC RNAs

1992 • 455 citations

Ribozymes: A Distinct Class of Metalloenzymes

1993 • 440 citations

Heparin Binds Endothelial Cell Growth Factor, the Principal Endothelial Cell Mitogen in Bovine Brain

1984 • 391 citations

Angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapy

1993 • 362 citations

Tumor angiogenesis is an independent prognostic indicator in primary breast carcinoma

1993 • 320 citations

Intratumoral microvessel density and L53 protein: Correlation with metastasis in head‐and‐neck squamous‐cell carcinoma

1993 • 314 citations

Purification of two distinct growth factors from bovine neural tissue by heparin affinity chromatography

1984 • 298 citations

Ligand-affinity cloning and structure of a cell surface heparan sulfate proteoglycan that binds basic fibroblast growth factor.

1990 • 274 citations

Proliferation of human malignant melanomas is inhibited by antisense oligodeoxynucleotides targeted against basic fibroblast growth factor.

1989 • 270 citations

Suppression of solid tumor growth by immunoneutralizing monoclonal antibody against human basic fibroblast growth factor.

1991 • 268 citations

Antiangiogenic agents potentiate cytotoxic cancer therapies against primary and metastatic disease.

1992 • 259 citations

Both normal and tumor cells produce basic fibroblast growth factor

1986 • 250 citations

Control of Angiogenesis by Heparin and Other Sulfated Polysaccharides

1992 • 225 citations

Pleiotrophin stimulates fibroblasts and endothelial and epithelial cells and is expressed in human cancer.

1992 • 215 citations

Basic fibroblast growth factor is an extracellular matrix component required for supporting the proliferation of vascular endothelial cells and the differentiation of PC12 cells.

1989 • 190 citations

Monoclonal antibodies against heparin-binding growth factor II/basic fibroblast growth factor that block its biological activity: invalidity of the antibodies for tumor angiogenesis.

1989 • 166 citations

Developing brain produces an angiogenesis factor.

1986 • 143 citations

Preparation of affinity-fractionated, heparin-derived oligosaccharides and their effects on selected biological activities mediated by basic fibroblast growth factor.

1993 • 138 citations

Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors.

1991 • 135 citations

Inhibition by Pentosan Polysulfate (PPS) of Heparin-Binding Growth Factors Released From Tumor Cells and Blockage by PPS of Tumor Growth in Animals

1992 • 127 citations

Tumor growth and angiogenesis induced by a secreted binding protein for fibroblast growth factors.

1994 • 125 citations

Basic fibroblast growth factor (bFGF) dissociates rapidly from heparan sulfates but slowly from receptors. Implications for mechanisms of bFGF release from pericellular matrix.

1992 • 114 citations

Structure and biological activities of a heparin-derived hexasaccharide with high affinity for basic fibroblast growth factor.

1993 • 107 citations

Tumor Growth Dependent on Kaposi's Sarcoma-Derived Fibroblast Growth Factor Inhibited by Pentosan Polysulfate

1991 • 106 citations

Interleukin-4 is a potent mitogen for capillary endothelium

1991 • 100 citations

Ribozyme-targeting elucidates a direct role of pleiotrophin in tumor growth.

1994 • 95 citations

Properties and Functions of Scatter Factor/Hepatocyte Growth Factor and Its Receptor c-Met

1993 • 80 citations

Endothelial cell growth factors in embryonic and adult chick brain are related to human acidic fibroblast growth factor.

1988 • 77 citations

Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena

1990 • 71 citations

Nerve growth factor and a fibroblast growth factor-like neurotrophic activity in cerebrospinal fluid of brain injured human patients

1993 • 68 citations

Autocrine growth stimulation by secreted Kaposi fibroblast growth factor but not by endogenous basic fibroblast growth factor.

1990 • 56 citations

Bifunctional effects of transforming growth factor-β (TGF-β) on endothelial cell growth correlate with phenotypes of TGF-β binding sites

1990 • 51 citations

Sequestration and Release of Basic Fibroblast Growth Factor^a

1991 • 48 citations

Heparan Sulfate Degradation in Tumor Cell Invasion and Angiogenesis

1988 • 29 citations

Detectable Inhibition of Heparin-Binding Growth Factor Activity in Sera From Patients Treated With Pentosan Polysulfate

1993 • 27 citations

Molecular foundations of Oncology

1991 • 26 citations

Self-Splicing and Enzymatic Activity of an Intervening Sequence RNA from Tetrahymena

2004 • 24 citations

Heparin‐Binding Growth Factor Blockade with Pentosan Polysulfate

1993 • 6 citations