Regulation of SOS mutagenesis by proteolysis.

Experiments in molecular genetics

1972 • 28,260 citations

DNA repair and mutagenesis

1996 • 2,289 citations

Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli

1976 • 1,572 citations

The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme

1987 • 731 citations

Isolation and characterization of mutants of Escherichia coli deficient in induction of mutations by ultraviolet light

1977 • 567 citations

Nature of the SOS-inducing signal in Escherichia coli

1990 • 524 citations

Regulation by proteolysis: energy-dependent proteases and their targets

1992 • 458 citations

RecA-mediated cleavage activates UmuD for mutagenesis: mechanistic relationship between transcriptional derepression and posttranslational activation.

1988 • 415 citations

Proteases and protein degradation inEscherichia coli

1992 • 387 citations

A molecular chaperone, ClpA, functions like DnaK and DnaJ.

1994 • 358 citations

UmuD mutagenesis protein of Escherichia coli: overproduction, purification, and cleavage by RecA.

1988 • 354 citations

RecA protein-dependent cleavage of UmuD protein and SOS mutagenesis.

1988 • 349 citations

Regulation of Escherichia coli starvation sigma factor (sigma s) by ClpXP protease

1996 • 323 citations

ClpX, an alternative subunit for the ATP-dependent Clp protease of Escherichia coli. Sequence and in vivo activities.

1993 • 317 citations

UV MUTAGENESIS IN RADIATION-SENSITIVE STRAINS OF YEAST

1976 • 255 citations

The ClpX heat-shock protein of Escherichia coli, the ATP-dependent substrate specificity component of the ClpP-ClpX protease, is a novel molecular chaperone.

1995 • 247 citations

Isolation and characterization of ClpX, a new ATP-dependent specificity component of the Clp protease of Escherichia coli.

1993 • 247 citations

Capsule synthesis in Escherichia coli K-12 is regulated by proteolysis

1987 • 242 citations

UmuC mutagenesis protein of Escherichia coli: purification and interaction with UmuD and UmuD'.

1989 • 222 citations

RcsA, an unstable positive regulator of capsular polysaccharide synthesis

1991 • 219 citations

Regulation of capsular polysaccharide synthesis in Escherichia coli K12

1991 • 218 citations

The Clp proteins: proteolysis regulators or molecular chaperones?

1992 • 216 citations

Activity of the purified mutagenesis proteins UmuC, UmuD', and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase III.

1992 • 199 citations

Addiction protein Phd of plasmid prophage P1 is a substrate of the ClpXP serine protease of Escherichia coli.

1995 • 188 citations

Levels of chromosomally encoded Umu proteins and requirements for in vivo UmuD cleavage

1991 • 177 citations

Structure of the UmuD′ protein and its regulation in response to DNA damage

1996 • 168 citations

Activity and specificity of Escherichia coli ClpAP protease in cleaving model peptide substrates.

1994 • 162 citations

The ATP-dependent Clp protease of Escherichia coli. Sequence of clpA and identification of a Clp-specific substrate.

1990 • 156 citations

Structural analysis of the umu operon required for inducible mutagenesis in Escherichia coli.

1985 • 138 citations

A new component of bacteriophage Mu replicative transposition machinery: the Escherichia coli ClpX protein

1994 • 132 citations

Dominant negative umuD mutations decreasing RecA-mediated cleavage suggest roles for intact UmuD in modulation of SOS mutagenesis.

1990 • 130 citations

Cold sensitivity induced by overproduction of UmuDC in Escherichia coli

1985 • 125 citations

Mutation induced by DNA damage: a many protein affair

1990 • 114 citations

Purification of a Soluble UmuD′C Complex from Escherichia coli

1996 • 105 citations

Mutagenesis induced by bacterial UmuDC proteins and their plasmid homologues

1992 • 104 citations

[11] Minimizing proteolysis in Escherichia coli: genetic solutions

1990 • 101 citations

SOS-regulated proteins in translesion DNA synthesis and mutagenesis

1995 • 101 citations

groE mutants of Escherichia coli are defective in umuDC-dependent UV mutagenesis

1989 • 82 citations

Survival, mutation and capacity to repair single-strand DNA breaks after gamma irradiation in different Exr− strains of Escherichia coli

1972 • 77 citations

Virulence in bacteriophage Mu: a case of trans-dominant proteolysis by the Escherichia coli Clp serine protease.

1992 • 64 citations

Bacteriophage Mu repressor as a target for the Escherichia coli ATP-dependent Clp Protease.

1996 • 60 citations

Coexpression of UmuD' with UmuC suppresses the UV mutagenesis deficiency of groE mutants

1992 • 59 citations

Analysis of recA mutants with altered SOS functions

1995 • 56 citations

In vivo stability of the Umu mutagenesis proteins: a major role for RecA

1996 • 50 citations

Isolation and characterization of novel plasmid-encoded umuC mutants

1994 • 41 citations

SOS mutagenesis

1993 • 38 citations

Escherichia coli umuDC mutants: DNA sequence alterations and UmuD cleavage

1992 • 38 citations