Requirement for, Promotion, or Inhibition by α-Tocopherol of Radical-Induced Initiation of Plasma Lipoprotein Lipid Peroxidation

Beyond Cholesterol

1989 • 6,533 citations

Oxidative stress: oxidants and antioxidants

1997 • 4,454 citations

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

1979 • 2,458 citations

The role of lipid peroxidation and antioxidants in oxidative modification of LDL

1992 • 2,335 citations

Continuous Monitoring ofin VztroOxidation of Human Low Density Lipoprotein

1989 • 1,824 citations

Antioxidant defenses and lipid peroxidation in human blood plasma.

1988 • 1,253 citations

Oxidative Stress: Oxidants and Antioxidants.

1992 • 1,193 citations

Vitamin E: application of the principles of physical organic chemistry to the exploration of its structure and function

1986 • 1,103 citations

The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma

1987 • 889 citations

Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol.

1991 • 786 citations

Tocopherol-mediated peroxidation. The prooxidant effect of vitamin E on the radical-initiated oxidation of human low-density lipoprotein

1993 • 710 citations

Role of vitamin E in preventing the oxidation of low-density lipoprotein

1991 • 649 citations

Role of oxidatively modified LDL in atherosclerosis

1990 • 614 citations

Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans.

1993 • 591 citations

Inhibition of oxidation of methyl linoleate in solution by vitamin E and vitamin C.

1984 • 580 citations

Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant

1992 • 513 citations

Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation

1994 • 512 citations

In the absence of catalytic metals ascorbate does not autoxidize at pH 7: ascorbate as a test for catalytic metals

1988 • 507 citations

Effect of oral supplementation with D-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation.

1991 • 477 citations

High density lipoprotein is the major carrier of lipid hydroperoxides in human blood plasma from fasting donors.

1992 • 471 citations

The Three-Dimensional Structure of an Arachidonic Acid 15-Lipoxygenase

1993 • 460 citations

Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.

1990 • 429 citations

Detection and characterization of lipid hydroperoxides at picomole levels by high-performance liquid chromatography

1987 • 362 citations

Human Atherosclerotic Plaque Contains Both Oxidized Lipids and Relatively Large Amounts of α-Tocopherol and Ascorbate

1995 • 357 citations

Supplementation with vitamin E but not beta-carotene in vivo protects low density lipoprotein from lipid peroxidation in vitro. Effect of cigarette smoking.

1992 • 354 citations

Autoxidation of lipids and antioxidation by alpha-tocopherol and ubiquinol in homogeneous solution and in aqueous dispersions of lipids: unrecognized consequences of lipid particle size as exemplified by oxidation of human low density lipoprotein.

1993 • 342 citations

Free radical-mediated chain oxidation of low density lipoprotein and its synergistic inhibition by vitamin E and vitamin C

1990 • 321 citations

[50] Rapid isolation of lipoproteins and assessment of their peroxidation by high-performance liquid chromatography postcolumn chemiluminescence

1994 • 313 citations

Effect of dietary supplementation with alpha-tocopherol on the oxidative modification of low density lipoprotein.

1992 • 299 citations

Recognition of oxidized low density lipoprotein by the scavenger receptor of macrophages results from derivatization of apolipoprotein B by products of fatty acid peroxidation

1989 • 294 citations

Content of antioxidants, preformed lipid hydroperoxides, and cholesterol as predictors of the susceptibility of human LDL to metal ion-dependent and -independent oxidation.

1993 • 275 citations

Oxidized LDL Binds to CD36 on Human Monocyte-Derived Macrophages and Transfected Cell Lines

1995 • 261 citations

Impaired ability of patients with familial isolated vitamin E deficiency to incorporate alpha-tocopherol into lipoproteins secreted by the liver.

1990 • 242 citations

A Method for Defining the Stages of Low-Density Lipoprotein Oxidation by the Separation of Cholesterol and Cholesteryl Ester-Oxidation Products Using HPLC

1993 • 221 citations

Prevention of Tocopherol-mediated Peroxidation in Ubiquinol-10-free Human Low Density Lipoprotein

1995 • 215 citations

A highly sensitive high-performance liquid chromatography method for the estimation of ascorbic and dehydroascorbic acid in tissues, biological fluids, and foods

1987 • 206 citations

[31] Antioxidant activities of bile pigments: Biliverdin and bilirubin

1990 • 204 citations

Involvement of 15-lipoxygenase in early stages of atherogenesis.

1994 • 196 citations

Lipoprotein oxidation: mechanistic aspects, methodological approaches and clinical relevance.

1994 • 154 citations

Cosupplementation With Coenzyme Q Prevents the Prooxidant Effect of α-Tocopherol and Increases the Resistance of LDL to Transition Metal–Dependent Oxidation Initiation

1996 • 153 citations

Reduction of Copper, but Not Iron, by Human Low Density Lipoprotein (LDL)

1995 • 152 citations

Impaired discrimination between stereoisomers of alpha-tocopherol in patients with familial isolated vitamin E deficiency.

1993 • 139 citations

Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities

1994 • 132 citations

Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein.

1995 • 130 citations

Lipoprotein oxidation

1994 • 122 citations

Oxidation of Lipids, XII. Inhibition of Oxidation of Soybean Phosphatidylcholine and Methyl Linoleate in Aqueous Dispersions by Uric Acid

1986 • 122 citations

α-Tocopherol as a Reductant for Cu(II) in Human Lipoproteins

1996 • 117 citations

Paradoxical actions of antioxidants in the oxidation of low density lipoprotein by peroxidases.

1995 • 111 citations

Comparison of supplementation of RRR-alpha-tocopherol and racemic alpha-tocopherol in humans. Effects on lipid levels and lipoprotein susceptibility to oxidation.

1993 • 111 citations

Reduction of HDL- and LDL-Associated Cholesterylester and Phospholipid Hydroperoxides by Phospholipid Hydroperoxide Glutathione Peroxidase and Ebselen (PZ-51)

1994 • 106 citations

Oxidation resistance, oxidation rate, and extent of oxidation of human low-density lipoprotein depend on the ration of oleic acid content to linoleic acid content studies in vitamin E deficient subjects

1993 • 104 citations

Interaction of α-tocopherol with copper and its effect on lipid peroxidation

1994 • 94 citations

Prooxidant role of vitamin E in copper induced lipid peroxidation

1993 • 93 citations

Inverse deuterium kinetic isotope effect for peroxidation in human low‐density lipoprotein (LDL): a simple test for tocopherol‐mediated peroxidation of LDL lipids

1995 • 70 citations

Low density lipoprotein oxidizability by copper correlates to its initial ubiquinol‐10 and polyunsaturated fatty acid content

1994 • 70 citations

Human plasma LDL cryopreserved with sucrose maintains in vivo kinetics indistinguishable from freshly isolated human LDL in cynomolgus monkeys.

1994 • 41 citations

Structure and motion of phospholipids in human plasma lipoproteins. A phosphorus-31 NMR study

1990 • 26 citations