Protein kinase C signals thromboxane induced increases in fibronectin synthesis and TGF-β bioactivity in mesangial cells

Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells.

1994 • 1,063 citations

Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy.

1993 • 819 citations

An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes.

1989 • 767 citations

Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II.

1992 • 648 citations

Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta.

1994 • 593 citations

Elevated expression of transforming growth factor-beta and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix.

1990 • 555 citations

Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney.

1993 • 525 citations

Immunodetection and quantitation of the two forms of transforming growth factor‐beta (TGF‐β1 and TGF‐β2) secreted by cells in culture

1989 • 453 citations

Characterization of the Mechanism for the Chronic Activation of Diacylglycerol-Protein Kinase C Pathway in Diabetes and Hypergalactosemia

1994 • 444 citations

Sustained expression of TGF-β1 underlies development of progressive kidney fibrosis

1994 • 413 citations

Fate of immunoprecipitable protein kinase C in GH3 cells treated with phorbol 12-myristate 13-acetate.

1985 • 387 citations

Localized production of TGF-β mRNA in tumour promoter-stimulated mouse epidermis

1988 • 275 citations

Activation of protein kinase C in glomerular cells in diabetes. Mechanisms and potential links to the pathogenesis of diabetic glomerulopathy

1994 • 273 citations

High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures

1991 • 251 citations

Expression of transforming growth factor-β1 during diabetic renal hypertrophy

1994 • 237 citations

Transforming growth factor-beta. Murine glomerular receptors and responses of isolated glomerular cells.

1989 • 235 citations

The emerging role of transforming growth factor-beta in kidney diseases

1994 • 217 citations

ELEVATED EXPRESSION OF TRANSFORMING GROWTH FACTOR BETA AND PROTEOGLYCAN PRODUCTION IN EXPERIMENTAL GLOMERULONEPHRITIS

1990 • 196 citations

Activation of the second promoter of the transforming growth factor-β1 gene by transforming growth factor-β1 and phorbol ester occurs through the same target sequences

1989 • 185 citations

Role for Protein Kinase C in the Mediation of Increased Fibronectin Accumulation by Mesangial Cells Grown in High-Glucose Medium

1993 • 178 citations

TGF-β1 in glomerulosclerosis and interstitial fibrosis of adriamycin nephropathy

1994 • 153 citations

A DNA motif related to the cAMP-responsive element and an exon-located activator protein-2 binding site in the human tissue-type plasminogen activator gene promoter cooperate in basal expression and convey activation by phorbol ester and cAMP.

1990 • 135 citations

Improvement of Renal Function with Selective Thromboxane Antagonism in Lupus Nephritis

1989 • 125 citations

Transforming growth factor-beta production in anti-glomerular basement membrane disease in the rabbit.

1991 • 123 citations

Activation of Latent Transforming Growth Factor ß

1993 • 118 citations

Autocrine secretion of transforming growth factor-β in cultured rat mesangial cells

1992 • 116 citations

Altered Steady-State mRNA Levels of Basement Membrane Proteins in Diabetic Mouse Kidneys and Thromboxane Synthase Inhibition

1990 • 115 citations

The mechanism for the activation of latent TGF-beta during co-culture of endothelial cells and smooth muscle cells: cell-type specific targeting of latent TGF-beta to smooth muscle cells.

1993 • 114 citations

Rat mesangial cell hypertrophy in response to transforming growth factor-β1

1993 • 85 citations

Transforming Growth Factor-β1 Enhances Glomerular Collagen Synthesis in Diabetic Rats

1993 • 85 citations

Eicosanoids in the Pathogenesis of the Functional and Structural Alterations of the Kidney in Diabetes

1993 • 84 citations

Evidence for the involvement of protein kinase activity in transforming growth factor-beta signal transduction.

1992 • 80 citations

Thromboxane in the pathogenesis of glomerular injury in diabetes

1992 • 76 citations

Transforming growth factor beta and epidermal growth factor alter calcium influx and phosphatidylinositol turnover in rat-1 fibroblasts.

1988 • 76 citations

Serum stimulation of fibronectin gene expression appears to result from rapid serum-induced binding of nuclear proteins to a cAMP response element.

1990 • 75 citations

Transforming growth factor-beta inhibits human vascular smooth muscle cell growth and migration.

1993 • 74 citations

Immunocharacterization of δ‐ and ζ‐isoenzymes of protein kinase C in rat renal mesangial cells

1992 • 67 citations

Phospholipase C activation by prostaglandins and thromboxane A2 in cultured mesangial cells

1988 • 61 citations

Transcriptional activation of matrix genes by transforming growth factor beta 1 in mesangial cells.

1993 • 52 citations

Characterization of a plasminogen activator and its inhibitor in human mesangial cells

1989 • 51 citations

Thromboxane and prostacyclin differentially regulate murine extracellular matrix gene expression

1993 • 46 citations

Effects of angiotensin II and of phorbol ester on protein kinase C activity and on prostacyclin production in cultured rat aortic smooth-muscle cells

1989 • 44 citations

Transforming growth factor beta activates protein kinase C in microvessels isolated from immature rat brain

1988 • 43 citations

Effects of thromboxane synthase inhibition with CGS 13080 in human cyclosporine nephrotoxicity

1992 • 41 citations

Transrepression of type II collagen by TGF‐β and FGF is protein kinase C dependent and is mediated through regulatory sequences in the promoter and first intron

1994 • 33 citations

The Effect of Transforming Growth Factor β1 on Mesangial Cell Fibronectin Synthesis: Increased Incorporation into the Extracellular Matrix and Reduced pI but No Effect on Alternative Splicing

1993 • 33 citations

Thromboxane binding and signal transduction in rat glomerular mesangial cells

1993 • 32 citations

Low-density lipoprotein stimulation of mesangial cell fibronectin synthesis: role of protein kinase C and transforming growth factor-beta.

1995 • 30 citations

Thromboxane/Prostaglandin Endoperoxide–Induced Hypertrophy of Rat Vascular Smooth Muscle Cells Is Signaled by Protein Kinase C–Dependent Increases in Transforming Growth Factor-β

1996 • 26 citations

Thromboxane stimulation of mesangial cell fibronectin synthesis is signalled by protein kinase C and modulated by cGMP

1994 • 25 citations

Thromboxane A2 regulates protein synthesis of cultured human mesangial cells.

1992 • 16 citations

Activation of protein kinase C reduces thromboxane receptors in glomeruli and mesangial cells

1993 • 15 citations

Thromboxane A2 receptor blockade improves renal function and histopathology in the post-obstructive kidney

1994 • 9 citations

Transforming growth factor-beta 1 regulation of signal transduction in two renal epithelial cell lines

1993 • 9 citations

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