Thromboxane/Prostaglandin Endoperoxide–Induced Hypertrophy of Rat Vascular Smooth Muscle Cells Is Signaled by Protein Kinase C–Dependent Increases in Transforming Growth Factor-β

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

THE SMOOTH MUSCLE CELL

1971 • 1,571 citations

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture.

1989 • 914 citations

An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes.

1989 • 767 citations

TGF-β induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop

1990 • 756 citations

Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II.

1992 • 648 citations

Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II.

1993 • 470 citations

Immunodetection and quantitation of the two forms of transforming growth factor‐beta (TGF‐β1 and TGF‐β2) secreted by cells in culture

1989 • 453 citations

Conversion of a high molecular weight latent β-TGF from chicken embryo fibroblasts into a low molecular weight active β-TGF under acidic conditions

1985 • 366 citations

[28] Use and specificity of staurosporine, UCN-O1, and calphostin C as protein kinase inhibitors

1991 • 338 citations

Transforming growth factor-beta-induced growth inhibition and cellular hypertrophy in cultured vascular smooth muscle cells.

1988 • 305 citations

Localized production of TGF-β mRNA in tumour promoter-stimulated mouse epidermis

1988 • 275 citations

Beta-type transforming growth factor specifies organizational behavior in vascular smooth muscle cell cultures.

1987 • 229 citations

Culture of quiescent arterial smooth muscle cells in a defined serum‐free medium

1983 • 220 citations

Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity.

1992 • 205 citations

Activation of the second promoter of the transforming growth factor-β1 gene by transforming growth factor-β1 and phorbol ester occurs through the same target sequences

1989 • 185 citations

Autocrine secretion of transforming growth factor-β in cultured rat mesangial cells

1992 • 116 citations

The direct measurement of protein kinase C (PKC) activity in isolated membranes using a selective peptide substrate

1991 • 110 citations

Thromboxane A2/prostaglandin H2-stimulated mitogenesis of coronary artery smooth muscle cells involves activation of mitogen-activated protein kinase and S6 kinase.

1994 • 108 citations

Dissociation of the contractile and hypertrophic effects of vasoconstrictor prostanoids in vascular smooth muscle.

1992 • 106 citations

Receptor-mediated mitogenic effect of thromboxane A2 in vascular smooth muscle cells

1990 • 93 citations

Protein kinase C signals thromboxane induced increases in fibronectin synthesis and TGF-β bioactivity in mesangial cells

1995 • 84 citations

Heparin selectively inhibits the transcription of tissue-type plasminogen activator in primate arterial smooth muscle cells during mitogenesis.

1992 • 82 citations

Thromboxane A2 stimulates vascular smooth muscle hypertrophy by up-regulating the synthesis and release of endogenous basic fibroblast growth factor

1993 • 79 citations

Thromboxane A2 stimulated signal transduction in vascular smooth muscle.

1993 • 73 citations

Thromboxane and vascular smooth muscle cell growth in genetically hypertensive rats.

1988 • 60 citations

Transforming growth factor-beta 1 gene activation and growth of smooth muscle from hypertensive rats.

1994 • 53 citations

Dissociation of vasoconstrictor-stimulated basic fibroblast growth factor expression from hypertrophic growth in cultured vascular smooth muscle cells. Relevant roles of protein kinase C.

1994 • 46 citations

Regulatory effect of thromboxane A2 on proliferation of vascular smooth muscle cells from rats

1992 • 32 citations

Low-density lipoprotein stimulation of mesangial cell fibronectin synthesis: role of protein kinase C and transforming growth factor-beta.

1995 • 30 citations