Regulation of Proliferation-Survival Decisions during Tumor Cell Hypoxia

Cancer: Principles and Practice of Oncology.

1991 • 8,402 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation

1997 • 1,590 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.

1996 • 1,183 citations

Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements.

1991 • 950 citations

The relevance of tumour pH to the treatment of malignant disease

1984 • 886 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

1988 • 811 citations

A rapid and simple method for the isolation of apoptotic DNA fragments

1994 • 660 citations

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

1996 • 654 citations

Programmed cell death and Bcl-2 protection in very low oxygen

1995 • 638 citations

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

1994 • 620 citations

Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL

1995 • 611 citations

Hypoxic fractions of solid tumors: Experimental techniques, methods of analysis, and a survey of existing data

1984 • 610 citations

Hypoxia and drug resistance

1994 • 555 citations

Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells.

1981 • 552 citations

Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification.

1996 • 488 citations

The Hypoxic Response: Huffing and HIFing

1997 • 482 citations

Imaging of hypoxia in human tumors with [F-18]fluoromisonidazole

1992 • 470 citations

Identification of Deoxyribonuclease II as an Endonuclease Involved in Apoptosis

1993 • 428 citations

Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma.

1996 • 365 citations

Intracellular Alkalinization Suppresses Lovastatin-induced Apoptosis in HL-60 Cells through the Inactivation of a pH-dependent Endonuclease

1995 • 306 citations

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.

1994 • 290 citations

Etoposide-induced apoptosis in human HL-60 cells is associated with intracellular acidification.

1993 • 286 citations

Taxol-Induced Mitotic Block Triggers Rapid Onset of a p53-Independent Apoptotic Pathway

1995 • 281 citations

Analysis of the Effects of Oxygen Supply and Demand on Hypoxic Fraction in Tumors

1995 • 268 citations

Oxidative stress-induced apoptosis prevented by trolox

1994 • 266 citations

Cell acidification in apoptosis: granulocyte colony-stimulating factor delays programmed cell death in neutrophils by up-regulating the vacuolar H(+)-ATPase.

1995 • 248 citations

Correlation of high lactate levels in human cervical cancer with incidence of metastasis.

1995 • 216 citations

Analysis of oxygen transport to tumor tissue by microvascular networks

1993 • 199 citations

Endonuclease activation during apoptosis: The role of cytosolic Ca2+ and pH

1992 • 179 citations

Apoptosis induced by mild hyperthermia in human and murine tumour cell lines: A study using electron microscopy and DNA gel electrophoresis

1991 • 162 citations

The Involvement of Protein Phosphatases in the Activation of ICE/CED-3 Protease, Intracellular Acidification, DNA Digestion, and Apoptosis

1996 • 158 citations

Induction of apoptosis at different oxygen tensions: evidence that oxygen radicals do not mediate apoptotic signaling.

1995 • 142 citations

BCL-2 and MCL-1 Expression in Chinese Hamster Ovary Cells Inhibits Intracellular Acidification and Apoptosis Induced by Staurosporine

1996 • 131 citations

Tumour Hypoxia: The Picture Has Changed in the 1990s

1994 • 117 citations

The oxygen effect and reoxygenation

1975 • 117 citations

Apoptosis in Human Adenocarcinoma HT29 Cells Induced by Exposure to Hypoxia

1995 • 95 citations

A Thin-Film Culturing Technique Allowing Rapid Gas-Liquid Equilibration (6 Sec) with No Toxicity to Mammalian Cells

1984 • 88 citations

Kinetic and Physical Studies of Cell Death Induced By Chemotherapeutic Agents Or Hyperthermia

1986 • 79 citations

Patterns of Glucose Metabolism in Normal and Virus-Transformed Chick Cells in Tissue Culture<xref ref-type="fn" rid="FN1">2</xref>

1972 • 73 citations

Apoptosis Induced by IL-2 Withdrawal Is Associated with an Intracellular Acidification

1995 • 72 citations

Hypoxia-inducible gene expression

1995 • 69 citations

Arteriolar oxygenation in tumour and subcutaneous arterioles: effects of inspired air oxygen content.

1996 • 58 citations

Effects of extreme hypoxia on the growth and viability of EMT6/SF mouse tumor cells in vitro.

1983 • 44 citations

Cell contact as a possible contribution to radiation resistance of some tumours

1972 • 22 citations

The Effect of Lactate on the Radiation Response of CHO-K1 Cells in Culture

1981 • 17 citations

Growth and glucose metabolism of high and low tumor-producing clones under aerobic and anaerobic conditions in vitro.

1969 • 15 citations

Influence of glucose on metabolism and growth of rat glioma cells (C6) in multicellular spheroid culture

1992 • 14 citations

The release of oxygen from polystyrene Petri dishes

1972 • 11 citations