The T-cell repertoire available for recognition of self-antigens

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

A very high level of crossreactivity is an essential feature of the T-cell receptor

1998 • 930 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Cross-Presentation, Dendritic Cells, Tolerance and Immunity

2001 • 894 citations

The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

1999 • 742 citations

Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation

2000 • 644 citations

Homeostasis-Stimulated Proliferation Drives Naive T Cells to Differentiate Directly into Memory T Cells

2000 • 527 citations

A Kinetic Basis For T Cell Receptor Repertoire Selection during an Immune Response

1999 • 515 citations

T cell homeostasis in patients with rheumatoid arthritis

2000 • 453 citations

T Cell Affinity Maturation by Selective Expansion during Infection

1999 • 420 citations

Impact of Negative Selection on the T Cell Repertoire Reactive to a Self-Peptide

2000 • 377 citations

Progression of autoimmune diabetes driven by avidity maturation of a T-cell population

2000 • 344 citations

Thymic involution in aging.

2000 • 305 citations

Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking

1991 • 270 citations

Fine Tuning of TCR Signaling by CD5

2001 • 270 citations

An inverse relationship between T cell receptor affinity and antigen dose during CD4⁺T cell responsesin vivoandin vitro

1999 • 259 citations

CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose

1999 • 245 citations

Immunologic Aspects of the Nonobese Diabetic (NOD) Mouse: Abnormalities of Cellular Immunity

1983 • 199 citations

An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptide

2001 • 187 citations

Antigen Concentration and Precursor Frequency Determine the Rate of CD8+ T Cell Tolerance to Peripherally Expressed Antigens

1999 • 174 citations

T-cell selection

1998 • 168 citations

Receptor editing in developing T cells

2000 • 157 citations

Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis

2001 • 139 citations

Self-antigen presentation by thymic stromal cells: a subtle division of labor

2000 • 135 citations

The Shaping of the T Cell Repertoire

2001 • 134 citations

Dynamic Tuning of T Cell Reactivity by Self-Peptide–Major Histocompatibility Complex Ligands

2001 • 114 citations

The Use of HLA A2.1/p53 Peptide Tetramers to Visualize the Impact of Self Tolerance on the TCR Repertoire

2000 • 110 citations

Age-Dependent T Cell Tolerance and Autoimmunity to Myelin Basic Protein

2001 • 109 citations

Ontogeny of T cell tolerance to peripherally expressed antigens

1999 • 107 citations

Differential Survival of Naive CD4 and CD8 T Cells

2000 • 98 citations

Functional cooperation between T helper cell determinants

2000 • 87 citations

Driver Clones and Determinant Spreading

2000 • 79 citations

T Cell Tolerance Based on Avidity Thresholds Rather Than Complete Deletion Allows Maintenance of Maximal Repertoire Diversity

2000 • 77 citations

A Kinetic Window Constricts the T Cell Receptor Repertoire in the Thymus

2001 • 76 citations

Characterization of CD8+ T Lymphocytes That Persist After Peripheral Tolerance to a Self Antigen Expressed in the Pancreas

2000 • 63 citations

Tracing and characterization of the low-avidity self-specific T cell repertoire

2000 • 58 citations

Circulating lymphocyte populations and autoantibodies in non-obese diabetic (NOD) mice: a longitudinal study.

1987 • 55 citations

Immunologic aspects of the nonobese diabetic (NOD) mouse. Abnormalities of cellular immunity

1983 • 53 citations

Defective CD8+ T Cell Peripheral Tolerance in Nonobese Diabetic Mice

2001 • 52 citations

A Low Affinity TCR Ligand Restores Positive Selection of CD8+ T Cells In Vivo

2001 • 42 citations

Spectrum of a QSO with redshift 3.8

1986 • 22 citations

Thymus reticulum of autoimmune mice. 3. Ultrastructural study of NOD (non-obese diabetic) mouse thymus.

1991 • 17 citations

Despite Epitope Spreading in the Pathogenesis of Autoimmune Disease, Highly Restricted Approaches to Immune Therapy may still Succeed [With a Hedge on this Bet]

2000 • 17 citations

CD4+ T cells that evade deletion by a self peptide display Th1-biased differentiation

2001 • 12 citations

Altered functional and biochemical response by CD8+ T cells that remain after tolerance

2001 • 6 citations