CD4+ T cells that evade deletion by a self peptide display Th1-biased differentiation

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells.

1995 • 699 citations

T Helper Cell Subsets in Insulin-Dependent Diabetes

1995 • 600 citations

Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations.

1995 • 554 citations

New perspectives of C1328-137-mediated T cell costimulation

1995 • 526 citations

T cell genetic background determines default T helper phenotype development in vitro.

1995 • 466 citations

An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis

1995 • 422 citations

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.

1994 • 418 citations

Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo.

1995 • 410 citations

Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype

1989 • 390 citations

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

1996 • 389 citations

Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells.

1990 • 386 citations

The Importance of Th2 Cytokines in Protective Immunity to Nematodes

1992 • 352 citations

Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation?

1995 • 347 citations

Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation

1998 • 332 citations

Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.

1987 • 310 citations

Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function

1991 • 286 citations

From Naive to Memory T Cells

1996 • 252 citations

CD4+ T-cell subsets in autoimmunity

1997 • 249 citations

Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production.

1994 • 216 citations

The interplay between the duration of TCR and cytokine signaling determines T cell polarization

1999 • 187 citations

Impaired Th2 Subset Development in the Absence of CD4

1997 • 124 citations

Genetic Regulation of Commitment to Interleukin 4 Production by a CD4+ T Cell–intrinsic Mechanism

1998 • 104 citations

TCR-Independent Pathways Mediate the Effects of Antigen Dose and Altered Peptide Ligands on Th Cell Polarization

1999 • 83 citations

Memory T cell development in the absence of specific antigen priming.

1996 • 83 citations

A Role for CD4 in Peripheral T Cell Differentiation

1997 • 70 citations

Peripheral Immune Tolerance Blocks Clonal Expansion but Fails to Prevent the Differentiation of Th1 Cells

1998 • 49 citations

Low avidity recognition of a class II-restricted neo-self peptide by virus-specific T cells

1995 • 37 citations

A major T cell determinant from the influenza virus hemagglutinin (HA) can be a cryptic self peptide in HA transgenic mice

1997 • 32 citations

Graded Deletion and Virus-Induced Activation of Autoreactive CD4+ T Cells

2000 • 24 citations

A new pattern for helix–turn–helix recognition revealed by the PU.1 ETS-domain–DNA complex

1998 • 18 citations