The Role of Endogenous Luminal Bacteria and Bacterial Products in the Pathogenesis of Experimental Enterocolitis and Systemic Inflammation

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Experimental models of inflammatory bowel disease

1995 • 1,215 citations

The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats.

1994 • 1,128 citations

Intestinal flora in health and disease

1984 • 826 citations

Cytokines in intestinal inflammation: Pathophysiological and clinical considerations

1994 • 607 citations

CURRENT CONCEPTS OF THE ETIOLOGY AND PATHOGENESIS OF ULCERATIVE COLITIS AND CROHN’S DISEASE

1995 • 398 citations

Mechanisms of acute and chronic intestinal inflammation induced by indomethacin

1993 • 315 citations

Resistance of germfree rats to indomethacin-induced intestinal lesions

1977 • 313 citations

Hepatic inflammation in rats with experimental small intestinal bacterial overgrowth

1990 • 211 citations

Normal Bacterial Populations of the Intestine and Their Relation to Intestinal Function

1964 • 207 citations

Spontaneous, heritable colitis in a new substrain of C3H/HeJ mice

1994 • 204 citations

Mucosal injury and inflammation in a model of chronic granulomatous colitis in rats

1993 • 181 citations

Granulomatous enterocolitis induced in rats by purified bacterial cell wall fragments

1985 • 179 citations

Hepatic injury associated with small bowel bacterial overgrowth in rats is prevented by metronidazole and tetracycline

1991 • 171 citations

Normal Bacterial Populations of the Intestine and Their Relation to Intestinal Function

1964 • 166 citations

Platelet‐activating factor: an endogenous mediator for bowel necrosis in endotoxemia

1987 • 154 citations

Inhibition of endotoxin-induced bacterial translocation in mice.

1989 • 140 citations

Tissue interleukin 1 and interleukin-1 receptor antagonist expression in enterocolitis in resistant and susceptible rats

1994 • 132 citations

Production of experimental ulcerative colitis in gnotobiotic guinea pigs with simplified microflora

1981 • 128 citations

Role of intestinal microflora in chronic inflammation and ulceration of the rat colon.

1994 • 125 citations

Protective effect of metronidazole in experimentalulcerative colitis

1978 • 116 citations

Mechanisms and Models in Rheumatoid Arthritis

1995 • 113 citations

Experimental portal fibrosis produced by intraportal injection of killed nonpathogenic Escherichia coli in rabbits

1988 • 107 citations

An immunocytochemical search for infectious agents in Crohn's disease.

1993 • 103 citations

The Chemotactic Peptide N-Formyl Methionyl-Loucyl-Phenylalanine Increases Mucosal Permeability in the Distal Ileum of the Rat

1988 • 94 citations

Degradation of endogenous bacterial cell wall polymers by the muralytic enzyme mutanolysin prevents hepatobiliary injury in genetically susceptible rats with experimental intestinal bacterial overgrowth.

1992 • 89 citations

Phlogistic properties of peptidoglycan-polysaccharide polymers from cell walls of pathogenic and normal-flora bacteria which colonize humans

1993 • 87 citations

Systemic uptake and intestinal inflammatory effects of luminal bacterial cell wall polymers in rats with acute colonic injury

1988 • 76 citations

Acute colitis produced by chemotactic peptides in rats and mice.

1985 • 74 citations

Evidence for peptidoglycan absorption in rats with experimental small bowel bacterial overgrowth

1991 • 68 citations

Insights into the pathogenesis of inflammatory bowel diseases provided by new rodent models of spontaneous colitis

1995 • 55 citations

Lipopolysaccharide induces recurrence of arthritis in rat joints previously injured by peptidoglycan-polysaccharide.

1987 • 54 citations

Role of Intestinal Microflora in Initiation and Perpetuation of Inflammatory Bowel Disease

1990 • 51 citations

Bacterial lipopolysaccharide-induced intestinal microvascular lesions leading to acute diarrhea.

1988 • 50 citations

Adsorbents as antiendotoxin agents in experimental colitis.

1993 • 49 citations

Reactivation of arthritis induced by small bowel bacterial overgrowth in rats: role of cytokines, bacteria, and bacterial polymers

1995 • 49 citations

Inflammatory Bowel Disease

1995 • 48 citations

Crohn's disease monocytes are primed for accentuated release of toxic oxygen metabolites

1993 • 45 citations

Bacteroides vulgatus outer membrane antigens associated with carrageenan-induced colitis in guinea pigs

1988 • 43 citations

Endotoxin-induced alterations in rat colonic water and electrolyte transport

1992 • 43 citations

Effects of Different Species of Bacteria on the Pathology of Enteric Amebiasis in Monocontaminated Guinea Pigs

1966 • 40 citations

Bacterial Cell-wall Induced Arthritis: Models of Chronic Recurrent Polyarthritis and Reactivation of Monoarticular Arthritis

1995 • 25 citations

Experimental colitis in rats induces low-grade endotoxinemia without hepatobiliary abnormalities

1994 • 17 citations

Normal bacteria stimulate colonic, gastric and systemic inflammation in HLA-B27/β2-m transgenic rats

1995 • 9 citations

Cytokine regulation of experimental intestinal inflammation

1994 • 9 citations

Genetic Factors in Animal Models of Intestinal Inflammation

1995 • 4 citations

Spontaneously colitic C3H/HeJBir mice demonstrate antibody reactivity to isolated colonies of enteric bacteria

1995 • 2 citations