Running has Differential Effects on NPY, Opiates, and Cell Proliferation in an Animal Model of Depression and Controls
Data up to Jan 2025
Total Citations Per Year
Abstract
References (79)
Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
2003 • 4,175 citations
Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus
2000 • 3,047 citations
Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
1991 • 2,982 citations
Running enhances neurogenesis, learning, and long-term potentiation in mice
1999 • 2,829 citations
Effects of Exercise Training on Older Patients With Major Depression
1999 • 1,254 citations
Anatomy of CNS opioid receptors
1988 • 1,178 citations
Exercise Treatment for Major Depression: Maintenance of Therapeutic Benefit at 10 Months
2000 • 1,052 citations
Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.
1992 • 1,001 citations
Are New Neurons Formed in the Brains of Adult Mammals?
1962 • 930 citations
Psychotomimesis Mediated by κ Opiate Receptors
1986 • 822 citations
Physical Activity Reduces the Risk of Subsequent Depression for Older Adults
2002 • 809 citations
VEGF is necessary for exercise‐induced adult hippocampal neurogenesis
2003 • 801 citations
Neurogenesis in the adult brain: death of a dogma
2000 • 796 citations
Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responses
2000 • 653 citations
Neuropsychopharmacology
2004 • 652 citations
Altered Responsiveness to Cocaine and Increased Immobility in the Forced Swim Test Associated with Elevated cAMP Response Element-Binding Protein Expression in Nucleus Accumbens
2001 • 508 citations
Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models
1989 • 378 citations
Neuronal adaptation to amphetamine and dopamine: Molecular mechanisms of prodynorphin gene regulation in rat striatum
1995 • 364 citations
The flinders sensitive line rats: A genetic animal model of depression
1993 • 363 citations
Neuropeptide Y functions as a neuroproliferative factor
2001 • 338 citations
Structure and expression of the rat neuropeptide Y gene.
1987 • 300 citations
Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant‐like effects
2004 • 296 citations
Effects of aerobic exercise on depression: a controlled study.
1985 • 290 citations
Endogenous dynorphins inhibit excitatory neurotransmission and block LTP induction in the hippocampus
1993 • 279 citations
Activation of Mouse T-Helper Cells Induces Abundant Preproenkephalin mRNA Synthesis
1986 • 269 citations
Neuropeptide Y and peptide YY as possible cerebrospinal fluid markers for major depression and schizophrenia, respectively
1988 • 256 citations
Comparing aerobic with nonaerobic forms of exercise in the treatment of clinical depression: A randomized trial
1989 • 251 citations
The antidepressant effect of running is associated with increased hippocampal cell proliferation
2005 • 230 citations
Delta FosB regulates wheel running.
2002 • 226 citations
Chronic mild stress-induced anhedonia: Greater effect in a genetic rat model of depression
1993 • 213 citations
Benefits of Exercise for the Treatment of Depression
1990 • 213 citations
ΔFosBRegulates Wheel Running
2002 • 182 citations
TECHNIQUES FOR ESTABLISHING SCHEDULES WITH WHEEL RUNNING AS REINFORCEMENT IN RATS
1993 • 177 citations
Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism
2003 • 173 citations
Nonpeptidic δ-opioid Receptor Agonists Reduce Immobility in the Forced Swim Assay in Rats
2002 • 172 citations
Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders Sensitive Line rats as an animal model of depression
1995 • 159 citations
Reduced Neuropeptide Y Concentrations in Suicide Brain
1992 • 158 citations
RUNNING AND RESPONDING REINFORCED BY THE OPPORTUNITY TO RUN: EFFECT OF REINFORCER DURATION
1997 • 143 citations
Neuropeptide-Y exerts antidepressant-like effects in the forced swim test in rats
2000 • 142 citations
Running and cocaine both upregulate dynorphin mRNA in medial caudate putamen
2000 • 132 citations
Selective breeding for sensitivity to the anticholinesterase DFP
1979 • 127 citations
Early Life Stress Changes Concentrations of Neuropeptide Y and Corticotropin-releasing Hormone in Adult Rat Brain. Lithium Treatment Modifies These Changes
2002 • 120 citations
Antidepressant drugs increase the concentration of neuropeptide Y (NPY)-like immunoreactivity in the rat brain
1988 • 117 citations
Involvement of hippocampal neuropeptide Y in mediating the chronic actions of lithium, electroconvulsive stimulation and citalopram
2000 • 116 citations
Mu‐ and delta‐opioid receptor antagonists decrease proliferation and increase neurogenesis in cultures of rat adult hippocampal progenitors
2003 • 113 citations
Anxiolytic activity of NPY receptor agonists in the conflict test
1997 • 100 citations
Alterations in neuropeptide Y levels and Y1 binding sites in the Flinders Sensitive Line rats, a genetic animal model of depression
1999 • 100 citations
Early maternal separation alters neuropeptide Y concentrations in selected brain regions in adult rats
2001 • 99 citations
Naloxone attenuates the conditioned place preference induced by wheel running in rats
2001 • 97 citations
Effect of repeated electroconvulsive treatment on regional concentrations of tachykinins, neurotensin, vasoactive intestinal polypeptide, neuropeptide Y, and galanin in rat brain
1989 • 96 citations
Involvement of δ-opioid receptors in the effects induced by endogenous enkephalins on learned helplessness model
1998 • 96 citations
Neuropeptide Y and corticotropin-releasing hormone in CSF mark response to antidepressive treatment with citalopram
2005 • 95 citations
Early maternal deprivation alters hippocampal levels of neuropeptide Y and calcitonin-gene related peptide in adult rats
2002 • 93 citations
Characterization of the Rat Prodynorphin Gene
1989 • 90 citations
Neuropeptide Y in male and female brains of flinders sensitive line, a rat model of depression. Effects of electroconvulsive stimuli
2000 • 89 citations
Electroconvulsive shocks increase the expression of neuropeptide Y (NPY) mRNA in the piriform cortex and the dentate gyrus
1994 • 87 citations
Neuropeptides and Electroconvulsive Treatment
1999 • 83 citations
Neuropeptide Y, neurokinin A and neurotensin in brain regions of Fawn Hooded “depressed”, wistar, and Sprague dawley rats. Effects of electroconvulsive stimuli
1998 • 82 citations
A high proportion of polymorphisms in the promoters of brain expressed genes influences transcriptional activity
2004 • 78 citations
δ Opioid receptor activation is required to induce LTP of synaptic transmission in the lateral perforant path in vivo
1991 • 77 citations
Selective breeding for sensitivity to DFP: Generalization of effects beyond criterion variables
1982 • 70 citations
Neuropeptide Y in brains of the Flinders Sensitive Line rat, a model of depression. Effects of electroconvulsive stimuli and d-amphetamine on peptide concentrations and locomotion
2000 • 70 citations
Cerebrospinal fluid neuropeptide Y in depression and schizophrenia
1987 • 68 citations
Effect of lithium on tachykinins, calcitonin gene‐related peptide, and neuropeptide Y in rat brain
1990 • 62 citations
Regulation of olfactory neurogenesis by amidated neuropeptides
2001 • 61 citations
Limbic effects of repeated electroconvulsive stimulation on neuropeptide Y and somatostatin mRNA expression in the rat brain
1995 • 60 citations
Addiction-Prone Lewis But Not Fischer Rats Develop Compulsive Running that Coincides with Downregulation of Nerve Growth Factor Inducible-B and Neuron-Derived Orphan Receptor 1
1999 • 59 citations
Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients
1996 • 58 citations
Search for biological correlates of depression and mechanisms of action of antidepressant treatment modalities. Do neuropeptides play a role?
2007 • 53 citations
Changed Concentrations of Tachykinins and Neuropeptide Y in Brain of a Rat Model of Depression Lithium Treatment Normalizes Tachykinins
2001 • 52 citations
Cerebrospinal fluid concentrations of neuropeptide Y in depressed patients and in controls.
1992 • 49 citations
Effects of electroconvulsive treatment on somatostattn, neuropeptide Y, endothelin, and neurokinin a concentrations in cerebrospinal fluid of depressed patients: A pilot study
1995 • 44 citations
Effects of electroconvulsive stimuli and MK-801 on neuropeptide Y, neurokinin A, and calcitonin gene-related peptide in rat brain.
1997 • 44 citations
Activated Transcription of the Human Neuropeptide Y Gene in Differentiating SH‐SY5Y Neuroblastoma Cells Is Dependent on Transcription Factors AP‐1, AP‐2α, and NGFI
1998 • 36 citations
Effects of antidepressant drug treatment on levels of NPY or prepro-NPY-mRNA in the rat brain
1993 • 27 citations
Retinoic acid negatively regulates neuropeptide Y expression in human neuroblastoma cells
2000 • 26 citations
Fos and Jun form cell specific protein complexes at the neuropeptide tyrosine promoter.
1994 • 25 citations
Neuropeptide Y inhibits in vitro epileptiform activity in the entorhinal cortex of mice
2002 • 19 citations
Molecular Cloning, Expression, and Characterization of Rat Homolog of Human AP-2α That Stimulates Neuropeptide Y Transcription Activity in Response to Nerve Growth Factor
2000 • 17 citations