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Running has Differential Effects on NPY, Opiates, and Cell Proliferation in an Animal Model of Depression and Controls

Data up to Jan 2025

Published2005
Citations68
References79

Total Citations Per Year

Abstract

References (79)

Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

2003 • 4,175 citations

Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus

2000 • 3,047 citations

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

1991 • 2,982 citations

Running enhances neurogenesis, learning, and long-term potentiation in mice

1999 • 2,829 citations

Effects of Exercise Training on Older Patients With Major Depression

1999 • 1,254 citations

Anatomy of CNS opioid receptors

1988 • 1,178 citations

Exercise Treatment for Major Depression: Maintenance of Therapeutic Benefit at 10 Months

2000 • 1,052 citations

Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.

1992 • 1,001 citations

Are New Neurons Formed in the Brains of Adult Mammals?

1962 • 930 citations

Psychotomimesis Mediated by κ Opiate Receptors

1986 • 822 citations

Physical Activity Reduces the Risk of Subsequent Depression for Older Adults

2002 • 809 citations

VEGF is necessary for exercise‐induced adult hippocampal neurogenesis

2003 • 801 citations

Neurogenesis in the adult brain: death of a dogma

2000 • 796 citations

Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responses

2000 • 653 citations

Neuropsychopharmacology

2004 • 652 citations

Altered Responsiveness to Cocaine and Increased Immobility in the Forced Swim Test Associated with Elevated cAMP Response Element-Binding Protein Expression in Nucleus Accumbens

2001 • 508 citations

Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models

1989 • 378 citations

Neuronal adaptation to amphetamine and dopamine: Molecular mechanisms of prodynorphin gene regulation in rat striatum

1995 • 364 citations

The flinders sensitive line rats: A genetic animal model of depression

1993 • 363 citations

Neuropeptide Y functions as a neuroproliferative factor

2001 • 338 citations

Structure and expression of the rat neuropeptide Y gene.

1987 • 300 citations

Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant‐like effects

2004 • 296 citations

Effects of aerobic exercise on depression: a controlled study.

1985 • 290 citations

Endogenous dynorphins inhibit excitatory neurotransmission and block LTP induction in the hippocampus

1993 • 279 citations

Activation of Mouse T-Helper Cells Induces Abundant Preproenkephalin mRNA Synthesis

1986 • 269 citations

Neuropeptide Y and peptide YY as possible cerebrospinal fluid markers for major depression and schizophrenia, respectively

1988 • 256 citations

Comparing aerobic with nonaerobic forms of exercise in the treatment of clinical depression: A randomized trial

1989 • 251 citations

The antidepressant effect of running is associated with increased hippocampal cell proliferation

2005 • 230 citations

Delta FosB regulates wheel running.

2002 • 226 citations

Chronic mild stress-induced anhedonia: Greater effect in a genetic rat model of depression

1993 • 213 citations

Benefits of Exercise for the Treatment of Depression

1990 • 213 citations

ΔFosBRegulates Wheel Running

2002 • 182 citations

TECHNIQUES FOR ESTABLISHING SCHEDULES WITH WHEEL RUNNING AS REINFORCEMENT IN RATS

1993 • 177 citations

Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism

2003 • 173 citations

Nonpeptidic δ-opioid Receptor Agonists Reduce Immobility in the Forced Swim Assay in Rats

2002 • 172 citations

Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders Sensitive Line rats as an animal model of depression

1995 • 159 citations

Reduced Neuropeptide Y Concentrations in Suicide Brain

1992 • 158 citations

RUNNING AND RESPONDING REINFORCED BY THE OPPORTUNITY TO RUN: EFFECT OF REINFORCER DURATION

1997 • 143 citations

Neuropeptide-Y exerts antidepressant-like effects in the forced swim test in rats

2000 • 142 citations

Running and cocaine both upregulate dynorphin mRNA in medial caudate putamen

2000 • 132 citations

Selective breeding for sensitivity to the anticholinesterase DFP

1979 • 127 citations

Early Life Stress Changes Concentrations of Neuropeptide Y and Corticotropin-releasing Hormone in Adult Rat Brain. Lithium Treatment Modifies These Changes

2002 • 120 citations

Antidepressant drugs increase the concentration of neuropeptide Y (NPY)-like immunoreactivity in the rat brain

1988 • 117 citations

Involvement of hippocampal neuropeptide Y in mediating the chronic actions of lithium, electroconvulsive stimulation and citalopram

2000 • 116 citations

Mu‐ and delta‐opioid receptor antagonists decrease proliferation and increase neurogenesis in cultures of rat adult hippocampal progenitors

2003 • 113 citations

Anxiolytic activity of NPY receptor agonists in the conflict test

1997 • 100 citations

Alterations in neuropeptide Y levels and Y1 binding sites in the Flinders Sensitive Line rats, a genetic animal model of depression

1999 • 100 citations

Early maternal separation alters neuropeptide Y concentrations in selected brain regions in adult rats

2001 • 99 citations

Naloxone attenuates the conditioned place preference induced by wheel running in rats

2001 • 97 citations

Effect of repeated electroconvulsive treatment on regional concentrations of tachykinins, neurotensin, vasoactive intestinal polypeptide, neuropeptide Y, and galanin in rat brain

1989 • 96 citations

Involvement of δ-opioid receptors in the effects induced by endogenous enkephalins on learned helplessness model

1998 • 96 citations

Neuropeptide Y and corticotropin-releasing hormone in CSF mark response to antidepressive treatment with citalopram

2005 • 95 citations

Early maternal deprivation alters hippocampal levels of neuropeptide Y and calcitonin-gene related peptide in adult rats

2002 • 93 citations

Characterization of the Rat Prodynorphin Gene

1989 • 90 citations

Neuropeptide Y in male and female brains of flinders sensitive line, a rat model of depression. Effects of electroconvulsive stimuli

2000 • 89 citations

Electroconvulsive shocks increase the expression of neuropeptide Y (NPY) mRNA in the piriform cortex and the dentate gyrus

1994 • 87 citations

Neuropeptides and Electroconvulsive Treatment

1999 • 83 citations

Neuropeptide Y, neurokinin A and neurotensin in brain regions of Fawn Hooded “depressed”, wistar, and Sprague dawley rats. Effects of electroconvulsive stimuli

1998 • 82 citations

A high proportion of polymorphisms in the promoters of brain expressed genes influences transcriptional activity

2004 • 78 citations

δ Opioid receptor activation is required to induce LTP of synaptic transmission in the lateral perforant path in vivo

1991 • 77 citations

Selective breeding for sensitivity to DFP: Generalization of effects beyond criterion variables

1982 • 70 citations

Neuropeptide Y in brains of the Flinders Sensitive Line rat, a model of depression. Effects of electroconvulsive stimuli and d-amphetamine on peptide concentrations and locomotion

2000 • 70 citations

Cerebrospinal fluid neuropeptide Y in depression and schizophrenia

1987 • 68 citations

Effect of lithium on tachykinins, calcitonin gene‐related peptide, and neuropeptide Y in rat brain

1990 • 62 citations

Regulation of olfactory neurogenesis by amidated neuropeptides

2001 • 61 citations

Limbic effects of repeated electroconvulsive stimulation on neuropeptide Y and somatostatin mRNA expression in the rat brain

1995 • 60 citations

Addiction-Prone Lewis But Not Fischer Rats Develop Compulsive Running that Coincides with Downregulation of Nerve Growth Factor Inducible-B and Neuron-Derived Orphan Receptor 1

1999 • 59 citations

Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients

1996 • 58 citations

Search for biological correlates of depression and mechanisms of action of antidepressant treatment modalities. Do neuropeptides play a role?

2007 • 53 citations

Changed Concentrations of Tachykinins and Neuropeptide Y in Brain of a Rat Model of Depression Lithium Treatment Normalizes Tachykinins

2001 • 52 citations

Cerebrospinal fluid concentrations of neuropeptide Y in depressed patients and in controls.

1992 • 49 citations

Effects of electroconvulsive treatment on somatostattn, neuropeptide Y, endothelin, and neurokinin a concentrations in cerebrospinal fluid of depressed patients: A pilot study

1995 • 44 citations

Effects of electroconvulsive stimuli and MK-801 on neuropeptide Y, neurokinin A, and calcitonin gene-related peptide in rat brain.

1997 • 44 citations

Activated Transcription of the Human Neuropeptide Y Gene in Differentiating SH‐SY5Y Neuroblastoma Cells Is Dependent on Transcription Factors AP‐1, AP‐2α, and NGFI

1998 • 36 citations

Effects of antidepressant drug treatment on levels of NPY or prepro-NPY-mRNA in the rat brain

1993 • 27 citations

Retinoic acid negatively regulates neuropeptide Y expression in human neuroblastoma cells

2000 • 26 citations

Fos and Jun form cell specific protein complexes at the neuropeptide tyrosine promoter.

1994 • 25 citations

Neuropeptide Y inhibits in vitro epileptiform activity in the entorhinal cortex of mice

2002 • 19 citations

Molecular Cloning, Expression, and Characterization of Rat Homolog of Human AP-2α That Stimulates Neuropeptide Y Transcription Activity in Response to Nerve Growth Factor

2000 • 17 citations

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