Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders Sensitive Line rats as an animal model of depression

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

1985 • 5,596 citations

Psychopharmacology: The third generation of progress

1988 • 3,403 citations

Behavioural despair in rats: A new model sensitive to antidepressant treatments

1978 • 3,035 citations

MANIC DEPRESSIVE ILLNESS

1984 • 3,013 citations

Neuropsychopharmacology

1990 • 1,545 citations

Manic-depressive illness

1991 • 1,538 citations

The validity of animal models of depression

1984 • 1,365 citations

Sensorimotor Gating and Schizophrenia

1990 • 1,307 citations

Chronic mild stress-induced anhedonia: A realistic animal model of depression

1992 • 1,120 citations

Is the forced swimming test a suitable model for revealing antidepressant activity?

1988 • 1,053 citations

Long-Term Antidepressant Treatment Decreases Spiroperidol-Labeled Serotonin Receptor Binding

1980 • 840 citations

Depression: The predisposing influence of stress

1982 • 431 citations

Animal models of depression: An overview

1990 • 425 citations

The flinders sensitive line rats: A genetic animal model of depression

1993 • 363 citations

Cholinergic Hyperactivity and Negative Schizophrenic Symptoms

1989 • 353 citations

Animal models as simulations of depression

1991 • 328 citations

Brain neurotransmitter receptors after long-term haloperidol: Dopamine, acetylcholine, serotonin, α-noradrenergic and naloxone receptors

1977 • 304 citations

Lithium Carbonate Augmentation of Antidepressant Treatment

1983 • 285 citations

Lithium Response in Unipolar Versus Bipolar Depression

1972 • 222 citations

Effects of psychotropic drugs on the behavior and neurochemistry of olfactory bulbectomized rats

1990 • 216 citations

Chronic mild stress-induced anhedonia: Greater effect in a genetic rat model of depression

1993 • 213 citations

THE EFFECTS OF DIISOPROPYLFLUOROPHOSPHONATE IN SCHIZOPHRENIA AND MANIC DEPRESSIVE PSYCHOSIS

1950 • 188 citations

Characterization of lithium potentiation of pilocarpine-induced status epilepticus in rats

1986 • 181 citations

5‐HT₂ receptor characteristics in frontal cortex and 5‐HT₂ receptor‐mediated head‐twitch behaviour following antidepressant treatment to mice

1984 • 163 citations

Regionally selective effects of intracerebral dopamine infusion on sensorimotor gating of the startle reflex in rats

1992 • 160 citations

Antidepressant withdrawal phenomena.

1984 • 155 citations

Mechanisms underlying sensitivity to organophosphorus anticholinesterase compounds

1987 • 154 citations

Selective breeding for increased cholinergic function: Development of a new animal model of depression

1986 • 151 citations

The Maudsley reactive and nonreactive strains: A North American perspective

1981 • 144 citations

Canopy Orientation: A New Kind of Orientation in Ants

1980 • 143 citations

Controlled trial of bright light for nonseasonal major depressive disorders

1992 • 141 citations

Genetic animal models of depression and ethanol preference provide support for cholinergic and serotonergic involvement in depression and alcoholism

1992 • 140 citations

Is cholinergic sensitivity a genetic marker for the affective disorders?

1994 • 139 citations

Blockade of the antidepressant-like effects of 8-OH-DPAT, buspirone and desipramine in the rat forced swim test by 5HT1A receptor antagonists

1995 • 130 citations

Selective breeding for diisopropyl fluorophosphate-sensitivity: Behavioural effects of cholinergic agonists and antagonists

1982 • 110 citations

Differential-reinforcement-of-low-rate 72-second schedule: selective effects of antidepressant drugs.

1983 • 103 citations

Evolutionary trends in the pharmacotherapeutic management of depression.

1994 • 102 citations

Age, race, blood pressure and renin: Predictors for antihypertensive treatment with calcium antagonists

1985 • 100 citations

Serotonin-stimulated Ca2+ response is increased in the blood platelets of depressed patients

1991 • 96 citations

Behavioral and neurochemical changes in rats dosed repeatedly with diisopropylfluorophosphate.

1991 • 96 citations

Animal Behavioural Studies in the Evaluation of Antidepressant Drugs

1992 • 96 citations

Stress-induced immobility in rats with cholinergic supersensitivity

1986 • 92 citations

Increased REM sleep in rats selectively bred for cholinergic hyperactivity

1988 • 89 citations

The effect of tianeptine and sertraline in three animal models of depression

1994 • 86 citations

Psychopharmacological properties of calcium channel inhibitors

1992 • 83 citations

EEG lateral asymmetries in psychiatric disorders

1984 • 79 citations

Genetic and pharmacological models of cholinergic supersensitivity and affective disorders

1988 • 78 citations

Acute and chronic effects of serotonin (5HT) antagonists on serotonin binding sites

1983 • 77 citations

Serotonin uptake and imipramine binding in blood platelets and brain of Fawn-hooded and Sprague Dawley rats

1983 • 76 citations

Selective breeding for differences in cholinergic function: Pre- and postsynaptic mechanisms involved in sensitivity to the anticholinesterase, DFP

1984 • 75 citations

Antidepressant withdrawal-induced activation (hypomania and mania): Mechanism and theoretical significance

1984 • 75 citations

Long-term lithium treatment selectively reduces receptor-coupled inositol phospholipid hydrolysis in rat brain

1989 • 73 citations

Immobility-reducing effects of antidepressants in a genetic animal model of depression

1992 • 70 citations

Behavior and corticosteroid response of maudsley reactive and nonreactive rats in the open field and forced swimming test

1991 • 70 citations

Effect of chronic antidepressant treatment on responses to apomorphine in selectively bred rat strains

1993 • 68 citations

Spouse-Aided Therapy with Agoraphobics

1992 • 68 citations

Calcium Antagonists in Manic-Depressive Illness

1993 • 65 citations

Animal Models in Psychiatry, II

1991 • 63 citations

Tolerance to low acetylcholinesterase levels: Modification of behavior without acute behavioral change

1972 • 62 citations

Differential Neuroendocrine Responses to the 5-HT Agonist m-Chlorophenylpiperazine in Fawn-Hooded Rats Relative to Wistar and Sprague-Dawley Rats

1988 • 61 citations

Ca2+ as messenger of 5HT2-receptor stimulation in human blood platelets

1984 • 60 citations

Role of central serotonergic neurons in the effect of sertraline in rats in the forced swimming test

1991 • 58 citations

Effects of cholinolytic agents on behavior following development of tolerance to low cholinesterase activity

1971 • 51 citations

Maudsley reactive and nonreactive rats differ only in some tasks reflecting emotionality

1992 • 50 citations

Selective breeding for increased cholinergic function: Increased serotonergic sensitivity

1988 • 46 citations

Antidepressant effects of rolipram in a genetic animal model of depression: Cholinergic supersensitivity and weight gain

1989 • 43 citations

Spatial Working and Reference Memory in Rats Bred for Autonomic Sensitivity to Cholinergic Stimulation: Acquisition, Accuracy, Speed, and Effects of Cholinergic Drugs

1995 • 41 citations

Swim test immobility co-segregates with serotonergic but not cholinergic sensitivity in cross-breeds of Flinders Line rats

1994 • 40 citations

Lack of anxiety in an animal model of depression with cholinergic supersensitivity

1991 • 39 citations

Rapid selection for serotonin-1A sensitivity in rats

1994 • 38 citations

The Effects of Tianeptine and other Antidepressants on a Rat Model of Depression

1992 • 37 citations

Enhanced benzodiazepine responsiveness in rats with increased cholinergic function

1988 • 35 citations

Do Calcium Antagonists Have a Place in the Treatment of Mood Disorders?

1991 • 34 citations

Treatment of Depressions Resistant to Tricyclic Antidepressants, Related Drugs or MAO-Inhibitors by Lithium Addition: Review of the Literature

1989 • 32 citations

Dopamine sensitivity in rats selectively bred for increases in cholinergic function

1991 • 32 citations

Defensive burying behavior in maudsley reactive (MR/Har) and nonreactive (MNRA/Har) rats

1989 • 25 citations

Neurobiologic effects of bright artificial light

1989 • 24 citations

The effects of Ca²⁺ antagonists and hydralazine on central 5‐hydroxytryptamine biochemistry and function in rats and mice

1990 • 23 citations

Flinders resistant hypocholinergic rats exhibit startle sensitization and reduced startle thresholds

1994 • 21 citations

Effects of dihydropyridine drugs on reversal by imipramine of helpless behavior in rats

1989 • 18 citations

Cardiovascular Drug Withdrawal Syndromes A Potential Problem with Calcium Antagonists?

1984 • 18 citations

Antidepressant-like action of nicardipine, verapamil and hemicholinium-3 injected into the anterior hypothalamus in the rat forced swim test

1990 • 18 citations

Effects of bright light on responsiveness to a muscarinic agonist in rats selectively bred for endogenously increased cholinergic function

1990 • 15 citations

Maudsley reactive and non-reactive rats differ in exploratory behavior but not in learning

1994 • 15 citations

The Olfactory Bulbectomized Rat as a Model of Major Depressive Disorder

2003 • 11 citations

Verapamil Is Not an Antidepressant in Patients Resistant to Tricyclic Antidepressants

1994 • 7 citations

Alcoholism and depressive disorders: is cholinergic sensitivity a biological marker?

1989 • 4 citations

Activity of several GABAergic agents on the behavioral “despair” test in rats

1989 • 4 citations

The action of antidepressant drugs administered during calcium channel blockade.

1993 • 2 citations