Human Macrophages Promote the Motility and Invasiveness of Osteopontin-Knockdown Tumor Cells

Inflammation and cancer

2002 • 14,174 citations

New functions for the matrix metalloproteinases in cancer progression

2002 • 5,937 citations

THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST.

1889 • 4,920 citations

New Perspectives in Cell Adhesion: RGD and Integrins

1987 • 4,835 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

2006 • 2,597 citations

The microenvironment of the tumour–host interface

2001 • 2,307 citations

Distinct Role of Macrophages in Different Tumor Microenvironments

2006 • 2,130 citations

Friends or foes — bipolar effects of the tumour stroma in cancer

2004 • 1,742 citations

Changing views of the role of matrix metalloproteinases in metastasis

1997 • 1,585 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors

2004 • 1,127 citations

Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

1999 • 937 citations

Receptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1)

1996 • 930 citations

Predicting hepatitis B virus–positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning

2003 • 837 citations

Tumor-Associated Macrophages Express Lymphatic Endothelial Growth Factors and Are Related to Peritumoral Lymphangiogenesis

2002 • 778 citations

Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases

1999 • 765 citations

Tumor–stroma interactions

2004 • 444 citations

Osteopontin expression and function: Role in bone remodeling

1998 • 422 citations

Macrophages Induce Invasiveness of Epithelial Cancer Cells Via NF-κB and JNK

2005 • 415 citations

Recognition of osteopontin and related peptides by an alpha v beta 3 integrin stimulates immediate cell signals in osteoclasts.

1991 • 387 citations

Elevated serum bone sialoprotein and osteopontin in colon, breast, prostate, and lung cancer.

2001 • 381 citations

Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF- dependent up-regulation of matrix metalloproteases

2004 • 369 citations

Tumor-Associated Macrophages: The Double-Edged Sword in Cancer Progression

2004 • 363 citations

Role of Osteopontin in Cellular Signaling and Toxicant Injury

2001 • 342 citations

Stromal cells can contribute oncogenic signals

2001 • 326 citations

Cytoskeletal changes in cell transformation and tumorigenesis

2001 • 313 citations

Prognostic significance of the metastasis-associated protein osteopontin in human breast cancer.

2002 • 257 citations

Osteopontin Stimulates Tumor Growth and Activation of Promatrix Metalloproteinase-2 through Nuclear Factor-κB-mediated Induction of Membrane Type 1 Matrix Metalloproteinase in Murine Melanoma Cells

2001 • 253 citations

Overexpression of osteopontin is associated with intrahepatic metastasis, early recurrence, and poorer prognosis of surgically resected hepatocellular carcinoma

2003 • 253 citations

Osteopontin Is Associated with T Cells in Sarcoid Granulomas and Has T Cell Adhesive and Cytokine-Like Properties In Vitro

1999 • 240 citations

Elevated expression of secreted phosphoprotein I (osteopontin, 2ar) as a consequence of neoplastic transformation.

1989 • 205 citations

Nuclear Factor-inducing Kinase Plays a Crucial Role in Osteopontin-induced MAPK/IκBα Kinase-dependent Nuclear Factor κB-mediated Promatrix Metalloproteinase-9 Activation

2004 • 172 citations

Significance of tumour-associated macrophages, vascular endothelial growth factor and thrombospondin-1 expression for tumour angiogenesis and prognosis in endometrial carcinomas

1999 • 165 citations

The identification of osteopontin as a metastasis-related gene product in a rodent mammary tumour model.

1996 • 147 citations

Pathogen-Induced Apoptotic Neutrophils Express Heat Shock Proteins and Elicit Activation of Human Macrophages

2004 • 128 citations

Angiogenesis Inhibition by Vascular Endothelial Growth Factor Receptor-2 Blockade Reduces Stromal Matrix Metalloproteinase Expression, Normalizes Stromal Tissue, and Reverts Epithelial Tumor Phenotype in Surface Heterotransplants

2005 • 125 citations

A secreted phosphoprotein marker for neoplastic transformation of both epithelial and fibroblastic cells

1983 • 113 citations

Osteopontin silencing by small interfering RNA suppresses in vitro and in vivo CT26 murine colon adenocarcinoma metastasis

2005 • 98 citations

Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12

2004 • 88 citations

Osteopontin is an autocrine mediator of hepatocyte growth factor-induced invasive growth.

2001 • 74 citations

Autocrine secretion of osteopontin by vascular smooth muscle cells regulates their adhesion to collagen gels.

1996 • 45 citations

Macrophage infiltration-associated thymidine phosphorylase expression correlates with increased microvessel density and poor prognosis in astrocytic tumors.

2001 • 36 citations

High Expression of Osteopontin mRNA in Human Macrophages but Not Human Vascular Smooth Muscle Cells in Culture

1995 • 5 citations