Predicting hepatitis B virus–positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning

Global cancer statistics

2011 • 55,498 citations

The Hallmarks of Cancer

2000 • 27,569 citations

Cluster analysis and display of genome-wide expression patterns

1998 • 16,410 citations

Molecular portraits of human breast tumours

2000 • 15,445 citations

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

2000 • 9,712 citations

Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray

1995 • 9,575 citations

Minimum information about a microarray experiment (MIAME)—toward standards for microarray data

2001 • 4,058 citations

Global cancer statistics

1999 • 3,388 citations

Rising Incidence of Hepatocellular Carcinoma in the United States

1999 • 2,875 citations

Primary carcinoma of the liver.A study of 100 cases among 48,900 necropsies

1954 • 2,755 citations

Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks

2001 • 2,626 citations

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

2002 • 2,400 citations

Prediction of central nervous system embryonal tumour outcome based on gene expression

2002 • 2,359 citations

Molecular classification of cutaneous malignant melanoma by gene expression profiling

2000 • 2,011 citations

Estimates of the worldwide mortality from 25 cancers in 1990

1999 • 1,494 citations

Cost-effectiveness analysis.

1993 • 814 citations

Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost effectiveness analysis

2001 • 653 citations

Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression.

2001 • 544 citations

Elevated serum bone sialoprotein and osteopontin in colon, breast, prostate, and lung cancer.

2001 • 381 citations

Hepatocellular Carcinoma-Cause, Treatment and Metastasis

2001 • 379 citations

Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver

2001 • 354 citations

Role of Osteopontin in Cellular Signaling and Toxicant Injury

2001 • 342 citations

Growth and spread of hepatocellular carcinoma: A review of 240 consecutive autopsy cases

1990 • 331 citations

A Paradigm for Class Prediction Using Gene Expression Profiles

2002 • 318 citations

Experience of 1000 patients who underwent hepatectomy for small hepatocellular carcinoma

2001 • 301 citations

The metastasis gene osteopontin: a candidate target for cancer therapy

2001 • 296 citations

Elevated plasma osteopontin in metastatic breast cancer associated with increased tumor burden and decreased survival.

1997 • 284 citations

P700: the primary electron donor of photosystem I

2001 • 244 citations

Establishment of a hepatocellular carcinoma cell line with unique metastatic characteristics through in vivo selection and screening for metastasis-related genes through cDNA microarray

2003 • 219 citations

Cell motility mediated by rho and rho-associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma

1999 • 159 citations

The identification of osteopontin as a metastasis-related gene product in a rodent mammary tumour model.

1996 • 147 citations

The association of chromosome 8p deletion and tumor metastasis in human hepatocellular carcinoma.

1999 • 121 citations

Prospective study of early detection for primary liver cancer

1997 • 117 citations

E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma

1996 • 112 citations

Contrasting expression of thrombospondin-1 and osteopontin correlates with absence or presence of metastatic phenotype in an isogenic model of spontaneous human breast cancer metastasis.

2002 • 103 citations

Sonographic screening for hepatocellular carcinoma in patients with chronic hepatitis or cirrhosis: an evaluation.

1998 • 100 citations

Intrahepatic metastases in hepatocellular carcinoma: the role of the portal vein as an efferent vessel

1996 • 98 citations

Distinctive gene expression profiles associated with Hepatitis B virus x protein

2001 • 97 citations

KAI1, A new metastasis suppressor gene, is reduced in metastatic hepatocellular carcinoma

1998 • 96 citations

E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma

1996 • 95 citations

Outcome of 67 Patients With Hepatocellular Cancer Detected During Screening of 1125 Patients With Chronic Hepatitis

1998 • 76 citations

Osteopontin is an autocrine mediator of hepatocyte growth factor-induced invasive growth.

2001 • 74 citations

Identification and Screening of 416 Patients with Chronic Hepatitis at High Risk to Develop Hepatocellular Cancer

1995 • 70 citations

Over-expression and lack of retinoblastoma protein are associated with tumor progression and metastasis in hepatocellular carcinoma

1999 • 57 citations

Tumor cells are the source of osteopontin and bone sialoprotein expression in human breast cancer.

1999 • 55 citations

Isolation of and effector for metastasis-inducing DNAs from a human metastatic carcinoma cell line

1997 • 52 citations

Morphological study of vascular dissemination in a metastatic hepatocellular carcinoma model in the monkey

1997 • 32 citations

Analysis of intrahepatic invasion of hepatocellular carcinoma using fluorescent dye-labeled cells in mice.

1999 • 16 citations