On the path to the heat shock response: destabilization and formation of partially folded protein intermediates, a consequence of protein thiol modification

Some Factors in the Interpretation of Protein Denaturation

1959 • 4,817 citations

Molecular chaperones in cellular protein folding

1996 • 3,540 citations

The Hsp70 and Hsp60 Chaperone Machines

1998 • 2,793 citations

A new puffing pattern induced by temperature shock and DNP in drosophila

1962 • 1,969 citations

Protein damage and degradation by oxygen radicals. I. general aspects.

1987 • 1,618 citations

Protein Folding

1992 • 1,601 citations

OXIDATION OF FREE AMINO ACIDS AND AMINO ACID RESIDUES IN PROTEINS BY RADIOLYSIS AND BY METAL-CATALYZED REACTIONS

1993 • 1,377 citations

Small heat shock proteins are molecular chaperones.

1993 • 1,376 citations

The induction of gene activity in drosophila by heat shock

1979 • 1,308 citations

The crystal structure of the asymmetric GroEL–GroES–(ADP)7 chaperonin complex

1997 • 1,250 citations

The Biology of heat shock proteins and molecular chaperones.

1994 • 1,226 citations

The biology of heat shock proteins and molecular chaperones

1994 • 1,203 citations

Metal ion-catalyzed oxidation of proteins: Biochemical mechanism and biological consequences

1990 • 1,143 citations

Heat shock, stress proteins, chaperones, and proteotoxicity

1991 • 1,069 citations

Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

1997 • 1,041 citations

Abnormal Proteins Serve as Eukaryotic Stress Signals and Trigger the Activation of Heat Shock Genes

1986 • 904 citations

Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly

1989 • 763 citations

Correlation between synthesis of heat shock proteins and development of thermotolerance in Chinese hamster fibroblasts.

1982 • 754 citations

Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells.

1989 • 699 citations

Variation in Sensitivity to Heat Shock during the Cell-cycle of Chinese Hamster Cellsin Vitro

1971 • 621 citations

Small Stress Proteins as Novel Regulators of Apoptosis

1996 • 614 citations

The effect of amino acid analogues and heat shock on gene expression in chicken embryo fibroblasts

1978 • 547 citations

Alpha B-crystallin is a small heat shock protein.

1991 • 526 citations

The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression.

1992 • 525 citations

BAG-1 modulates the chaperone activity of Hsp70/Hsc70

1997 • 511 citations

Protein folding

1990 • 502 citations

Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock. HSP27 stabilization of the microfilament organization.

1993 • 494 citations

Induced thermal resistance in HeLa cells

1975 • 494 citations

The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding.

1996 • 424 citations

Cultured animal cells exposed to amino acid analogues or puromycin rapidly synthesize several polypeptides

1980 • 395 citations

A hitchhiker's guide to the human Hsp70 family

1996 • 378 citations

Thermal response of rat fibroblasts stably transfected with the human 70-kDa heat shock protein-encoding gene.

1991 • 365 citations

In Vivo Observation of Polypeptide Flux through the Bacterial Chaperonin System

1997 • 345 citations

Transition series metals and sulfhydryl reagents induce the synthesis of four proteins in eukaryotic cells

1980 • 343 citations

1 Progress and Perspectives on the Biology of Heat Shock Proteins and Molecular Chaperones

1994 • 342 citations

GroEL‐Mediated protein folding

1997 • 336 citations

Heat shock gene regulation by nascent polypeptides and denatured proteins: hsp70 as a potential autoregulatory factor

1992 • 336 citations

THE ROLE OF THEhsp90-BASED CHAPERONE SYSTEM IN SIGNAL TRANSDUCTION BY NUCLEAR RECEPTORS AND RECEPTORS SIGNALING VIA MAP KINASE

1997 • 329 citations

Negative strand viruses and the host cell.

1978 • 328 citations

The role of trehalose synthesis for the acquisition of thermotolerance in yeast

1994 • 320 citations

In vitro activation of heat shock transcription factor DNA-binding by calcium and biochemical conditions that affect protein conformation.

1990 • 295 citations

Chaperones get in touch: the Hip-Hop connection

1997 • 289 citations

Dissociation as a result of phosphorylation of an aggregated form of the small stress protein, hsp27

1994 • 246 citations

Multiple Layers of Regulation of Human Heat Shock Transcription Factor 1

1995 • 246 citations

A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor

1996 • 240 citations

Examining the function and regulation of hsp 70 in cells subjected to metabolic stress

1992 • 236 citations

Interaction of the Immunosuppressant Deoxyspergualin with a Member of the Hsp70 Family of Heat Shock Proteins

1992 • 232 citations

Oxidation of glutathione by the superoxide radical to the disulfide and the sulfonate yielding singlet oxygen

1983 • 227 citations

hsp27 as a Switch between Differentiation and Apoptosis in Murine Embryonic Stem Cells

1997 • 220 citations

Hydrogen peroxide or heat shock induces resistance to hydrogen peroxide in Chinese hamster fibroblasts

1987 • 217 citations

hsp110 Protects Heat-denatured Proteins and Confers Cellular Thermoresistance

1997 • 217 citations

Characterization of 45‐kDa/54‐kDa HSP27 Kinase, a Stress‐Sensitive Kinase Which may Activate the Phosphorylation‐Dependent Protective Function of Mammalian 27‐kDa Heat‐shock Protein HSP27

1995 • 203 citations

Activation of Heat Shock Factor by Alkylating Agents Is Triggered by Glutathione Depletion and Oxidation of Protein Thiols

1996 • 182 citations

Protein Denaturation during Heat Shock and Related Stress

1989 • 166 citations

Protein denaturation in intact hepatocytes and isolated cellular organelles during heat shock

1993 • 162 citations

Heat shock: the role of transient inducible responses in cell damage, transformation, and differentiation.

1991 • 154 citations

The effect of X-rays on enzymes

1940 • 151 citations

Inhibition of heat shock (stress) protein induction by deuterium oxide and glycerol: Additional support for the abnormal protein hypothesis of induction

1989 • 143 citations

Evidence for a role of Hsp 70 in the regulation of the heat shock response in mammalian cells

1996 • 141 citations

Identification of a Major Subfamily of Large hsp70-like Proteins through the Cloning of the Mammalian 110-kDa Heat Shock Protein

1995 • 135 citations

Stress- and mitogen-induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperone properties and cellular thermoresistance.

1994 • 132 citations

Aggregation and Precipitation of Human Relaxin Induced by Metal-Catalyzed Oxidation

1995 • 130 citations

Thermal analysis of CHL V79 cells using differential scanning calorimetry: Implications for hyperthermic cell killing and the heat shock response

1988 • 130 citations

Analysis of the resistance to heat and hydrogen peroxide stresses in COS cells transiently expressing wild type or deletion mutants of the Drosophila 27‐kDa heat‐shock protein

1993 • 129 citations

The Carboxyl-Terminal Transactivation Domain of Heat Shock Factor 1 Is Negatively Regulated and Stress Responsive

1995 • 128 citations

Association between the mammalian 110,000-dalton heat-shock protein and nucleoli.

1983 • 121 citations

Heat-shock proteins Hsp104 and Hsp70 reactivate mRNA splicing after heat inactivation

1995 • 120 citations

Molecular basis of cooperativity in protein folding. V. Thermodynamic and structural conditions for the stabilization of compact denatured states

1994 • 117 citations

Proteins containing non-native disulfide bonds generated by oxidative stress can act as signals for the induction of the heat shock response

1997 • 116 citations

Evidence for two states of thermotolerance in mammalian cells

1988 • 107 citations

Heat Shock Response - Pathophysiological Implications

1997 • 103 citations

Complexes between nascent polypeptides and their molecular chaperones in the cytosol of mammalian cells.

1997 • 101 citations

Dephosphorylation of the small heat shock protein Hsp27 in vivo by protein phosphatase 2A.

1994 • 100 citations

Formation of disulfides with diamide

1987 • 100 citations

Hormone 1 alpha,25-dihydroxyvitamin D3 modulates heat shock response in monocytes

1987 • 96 citations

Correlation between glutathione oxidation and trimerization of heat shock factor 1, an early step in stress induction of the Hsp response

1998 • 95 citations

Protein Denaturation During Heat Shock and Related Stress

1990 • 91 citations

A 16-kDa Protein Functions as a New Regulatory Protein for Hsc70 Molecular Chaperone and Is Identified as a Member of the Nm23/Nucleoside Diphosphate Kinase Family

1997 • 90 citations

The effect of changes in the respiratory metabolism upon genome activity in Drosophila

1972 • 88 citations

Denaturation of proteins during heat shock. In vivo recovery of solubility and activity of reporter enzymes

1991 • 82 citations

Abnormal proteins as the trigger for the induction of stress responses: Heat, diamide, and sodium arsenite

1988 • 79 citations

The possible role of the superoxide ion in the induction of heat-shock and specific proteins in aerobic Drosophila cells during return to normoxia after a period of anaerobiosis

1983 • 73 citations

Differential Expression of hsp70 Stress Proteins in Human Endothelial Cells Exposed to Heat Shock and Hydrogen Peroxide

1991 • 73 citations

A comparison of protein S-thiolation (protein mixed-disulfide formation) in heart cells treated with t-butyl hydroperoxide or diamide

1986 • 72 citations

Characterization of a signal generated by oxidation of protein thiols that activates the heat shock transcription factor

1995 • 71 citations

Effects of Protein Stabilizing Agents on Thermal Backbone Motions: A Disulfide Trapping Study

1996 • 66 citations

Gamma Irradiation Increases hsp-70 in Chinese Hamster Ovary Cells

1993 • 61 citations

Oxidative Stress Transforms Acetylcholinesterase to a Molten Globule-like State

1994 • 60 citations

Destabilization of the Ca²⁺-ATPase of Sarcoplasmic Reticulum by Thiol-Specific, Heat Shock Inducers Results in Thermal Denaturation at 37 °C

1997 • 59 citations

Oxidative Stress and Heat Shock Protein Induction in Human Cells

1987 • 58 citations

Characterization of denatured protein inducers of the heat shock (stress) response in Xenopus laevis oocytes.

1994 • 50 citations

Destabilization and denaturation of cellular protein by glutathione depletion

1997 • 48 citations

Specificity of the Escherichia coli chaperone DnaK (70-kDa heat shock protein) for hydrophobic amino acids.

1993 • 46 citations

Oxidative modification of Escherichia coli glutamine synthetase. Decreases in the thermodynamic stability of protein structure and specific changes in the active site conformation.

1992 • 45 citations

Oxidative stress induces a subset of heat shock proteins in rat hepatocytes and MH1C1 cells

1988 • 43 citations

Diamide exposure, thermal resistance, and synthesis of stress (heat shock) proteins

1987 • 25 citations

Synthesis of heat shock proteins following oxidative challenge: role of glutathione

1994 • 15 citations

Early Activation of Heat Shock Genes in H₂O₂-Treated Drosophila Cells

1990 • 11 citations

Modulation of diamide toxicity in thermotolerant cells by inhibition of protein synthesis.

1989 • 10 citations

Diamide-induced cytotoxicity and thermotolerance in CHO cells

1998 • 9 citations

Deleted Work

1955 • 0 citations