The Clk2 and Clk3 Dual-Specificity Protein Kinases Regulate the Intranuclear Distribution of SR Proteins and Influence Pre-mRNA Splicing

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

SV40-transformed simian cells support the replication of early SV40 mutants

1981 • 2,564 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

[2] Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members

1991 • 1,225 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

SR proteins: a conserved family of pre-mRNA splicing factors.

1992 • 766 citations

ALTERNATIVE SPLICING IN THE CONTROL OF GENE EXPRESSION

1989 • 701 citations

SR proteins and splicing control.

1996 • 668 citations

Regulation of Alternative Splicing in Vivo by Overexpression of Antagonistic Splicing Factors

1994 • 612 citations

Macromolecular Domains within the Cell Nucleus

1993 • 611 citations

The dynamics of a pre-mRNA splicing factor in living cells

1997 • 604 citations

The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.

1996 • 559 citations

A serine kinase regulates intracellular localization of splicing factors in the cell cycle

1994 • 511 citations

Distinct Functions of SR Proteins in Alternative pre-mRNA Splicing

1993 • 407 citations

Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing.

1997 • 394 citations

A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription.

1991 • 344 citations

tyk2, prototype of a novel class of non-receptor tyrosine kinase genes.

1990 • 322 citations

Ultrastructural distribution of nuclear ribonucleoproteins as visualized by immunocytochemistry on thin sections.

1984 • 306 citations

Localization of pre-mRNA splicing in mammalian nuclei

1994 • 269 citations

The SR protein family: pleiotropic functions in pre-mRNA splicing

1996 • 259 citations

Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF.

1993 • 241 citations

Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation.

1992 • 232 citations

Dynamic relocation of transcription and splicing factors dependent upon transcriptional activity

1997 • 197 citations

A monoclonal antibody that recognizes a phosphorylated epitope stains lampbrush chromosome loops and small granules in the amphibian germinal vesicle.

1990 • 193 citations

A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators.

1991 • 192 citations

The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo.

1994 • 186 citations

Intron-dependent recruitment of pre-mRNA splicing factors to sites of transcription.

1996 • 174 citations

STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases.

1991 • 128 citations

The Doa locus encodes a member of a new protein kinase family and is essential for eye and embryonic development in Drosophila melanogaster.

1994 • 111 citations

pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity

1991 • 108 citations

Characterization by cDNA Cloning of Two New Human Protein Kinases

1994 • 98 citations

Alternative Splicing of STY, a Nuclear Dual Specificity Kinase

1995 • 73 citations

Differentiation of F9 embryonal carcinoma cells induced by the c-jun and activated c-Ha-ras oncogenes.

1990 • 69 citations

AFC1, a LAMMER kinase from Arabidopsis thaliana, activates STE12-dependent processes in yeast.

1994 • 48 citations

The KNS1 gene of Saccharomyces cerevisiae encodes a nonessential protein kinase homologue that is distantly related to members of the CDC28/cdc2 gene family

1991 • 46 citations

The Dual-Specificity CLK Kinase Induces Neuronal Differentiation of PC12 Cells

1994 • 43 citations

The dual-specificity CLK kinase induces neuronal differentiation of PC12 cells.

1994 • 27 citations

Dual specificity kinases ? a new family of signal transducers

1994 • 24 citations