Antigen presentation by human fetal astrocytes with the cooperative effect of microglia or the microglial-derived cytokine IL-1

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

Quantitation of mRNA by the polymerase chain reaction.

1989 • 1,648 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes

1986 • 1,282 citations

T‐lymphocyte entry into the central nervous system

1991 • 1,168 citations

Production of hybridoma growth factor by human monocytes

1987 • 1,133 citations

Blood-Brain Barrier in Physiology and Medicine

1976 • 888 citations

Interleukin 1 of the central nervous system is produced by ameboid microglia.

1986 • 858 citations

Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta.

1993 • 789 citations

Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus.

1989 • 785 citations

Astrocytes present myelin basic protein to encephalitogenic T-cell lines

1984 • 773 citations

Cellular immune reactivity within the CNS

1986 • 771 citations

Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells.

1982 • 754 citations

T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

1990 • 745 citations

Early molecular events in the induction phase of contact sensitivity.

1992 • 660 citations

Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view

1992 • 653 citations

Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells

1987 • 648 citations

Production of tumor necrosis factor-alpha by microglia and astrocytes in culture

1989 • 626 citations

Cytokine expression in the brain during the acquired immunodeficiency syndrome

1992 • 572 citations

Identification of a membrane-associated interleukin 1 in macrophages.

1985 • 487 citations

Astrocytes as antigen-presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune interferon and its effect on antigen presentation.

1985 • 440 citations

Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alpha.

1992 • 402 citations

Selection for T-cell receptor Vβ–Dβ–Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis

1993 • 400 citations

Blood–Brain Barrier in Physiology and Medicine

1977 • 395 citations

Cotransfection of ICAM-1 and HLA-DR reconstitutes human antigen-presenting cell function in mouse L cells

1989 • 389 citations

Bone marrow derived elements and resident microglia in brain inflammation

1993 • 352 citations

Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain.

1986 • 316 citations

Microglia are the major cell type expressing MHC class II in human white matter

1987 • 302 citations

Brain macrophages synthesize interleukin‐1 and interleukin‐1 mRNAs in vitro

1988 • 286 citations

On the presence of Ia-positive endothelial cells and astrocytes in multiple sclerosis lesions and its relevance to antigen presentation

1985 • 241 citations

Viral particles induce Ia antigen expression on astrocytes

1986 • 241 citations

Measurement by quantitative PCR of changes in HPRT, PGK-1, PGK-2, APRT, MTase, and Zfy gene transcripts during mouse spermatogenesis

1990 • 231 citations

T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells.

1988 • 212 citations

Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors.

1990 • 207 citations

Immunohistochemical analysis of the rat central nervous system during experimental allergic encephalomyelitis, with special reference to Ia-positive cells with dendritic morphology.

1986 • 204 citations

In vitro production of IL-6, IL-1 beta, and tumor necrosis factor-alpha by human embryonic microglial and neural cells.

1993 • 195 citations

Experimental autoimmune encephalomyelitis is exacerbated by IL-1 alpha and suppressed by soluble IL-1 receptor.

1991 • 183 citations

A simple sensitive bioassay for interleukin-1 which is unresponsive to 103 U/ml of interleukin-2

1987 • 170 citations

B7/BB‐1 antigen expression on adult human microglia studied in vitro and in situ

1994 • 167 citations

Hyperinducibility of Ia antigen on astrocytes correlates with strain-specific susceptibility to experimental autoimmune encephalomyelitis.

1987 • 163 citations

Biology of Adult Human Microglia in Culture: Comparisons with Peripheral Blood Monocytes and Astrocytes

1992 • 162 citations

Immune regulation by brain cells in the central nervous system: microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions.

1992 • 160 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 154 citations

Ultrastructural Location of Major Histocompatibility Complex (MHC) Class II Positive Perivascular Cells in Histologically Normal Human Brain

1992 • 148 citations

Multiple Sclerosis: A Role for Astroglia in Active Demyelination Suggested by Class II MHC Expression and Ultrastructural Study

1990 • 145 citations

Antigen presentation by human monocytes: evidence for stimulant processing and requirement for interleukin 1.

1983 • 131 citations

Phenotypic Differences between Human Monocytes/Macrophages and Microglial Cells StudiedIn SituandIn Vitro

1994 • 118 citations

Tumor necrosis factor and interleukin-1 in the CSF and sera of patients with multiple sclerosis

1991 • 117 citations

Expression of Ia molecules by astrocytes during acute experimental allergic encephalomyelitis in the Lewis rat

1985 • 115 citations

Cellular immune response in multiple sclerosis plaques.

1990 • 112 citations

In situ demonstration of proliferating cells in the rat central nervous system during experimental autoimmune encephalomyelitis. Evidence suggesting that most infiltrating T cells do not proliferate in the target organ.

1992 • 112 citations

Apoptosis of αβ T lymphocytes in the nervous system in experimental autoimmune encephalomyelitis: Its possible implications for recovery and acquired tolerance

1992 • 111 citations

Human astrocytes are only partially competent antigen presenting cells

1994 • 106 citations

IL-6 and IL-1 synergize to stimulate IL-2 production and proliferation of peripheral T cells.

1989 • 102 citations

Resident macrophages (ramified microglia) of the adult brown Norway rat central nervous system are constitutively major histocompatibility complex class II positive.

1993 • 100 citations

Distinct roles of IL-1 and IL-6 in human T cell activation.

1989 • 95 citations

Accessory factors involved in murine T cell activation. Distinct roles of interleukin 6, interleukin 1 and tumor necrosis factor

1990 • 81 citations

Flavivirus infection up-regulates the expression of class I and class II major histocompatibility antigens on and enhances T cell recognition of astrocytes in vitro

1989 • 77 citations

Induction of primary T cell responses by human glial cells

1993 • 77 citations

Biological and biochemical characterization of an interleukin 1‐like factor from rat C₆ glioma cells

1983 • 75 citations

Antigen-presenting cells for unprimed T cells

1989 • 74 citations

Macrophage-dependent activation of antigen-specific T cells requires antigen and a soluble monokine.

1983 • 68 citations

A Transgenic Approach to the Study of Peripheral T‐Cell Tolerance

1991 • 54 citations

The identity of cells expressing MHC class II antigens in normal and pathological human brain

1992 • 54 citations

Modulation of major histocompatibility complex antigen expression by viral infection.

1994 • 53 citations

Evidence for antigen presentation in situ by endothelial cells and astrocytes

1985 • 50 citations

Antigen presentation by EBV-B cells to resting and activated T cells: role of interleukin 1.

1985 • 48 citations

Expression and Modulation of HLA-DR on Cultured Human Adult Astrocytes

1991 • 40 citations

Astrocyte-derived interleukin-1-like factors.

1984 • 33 citations

Leucocyte recruitment and inflammation in the CNS

1992 • 30 citations

IL-1 is an autocrine growth factor for T cell clones.

1988 • 26 citations

Expression of Major Histocompatibility Complex Antigens and Serum Neutralizing Antibody in Murine Retroviral Encephalitis

1993 • 17 citations