CD40-CD154 Interaction and IFN-γ Are Required for IL-12 But Not Prostaglandin E2 Secretion by Microglia During Antigen Presentation to Th1 Cells

Microglia: a sensor for pathological events in the CNS

1996 • 4,309 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses

1998 • 1,253 citations

Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines.

1991 • 835 citations

The adhesion molecule and cytokine profile of multiple sclerosis lesions

1995 • 761 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production.

1995 • 676 citations

Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells

1987 • 648 citations

Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery.

1992 • 627 citations

Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide

1998 • 568 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

1995 • 560 citations

CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis.

1996 • 492 citations

Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes.

1993 • 491 citations

Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions.

1995 • 473 citations

Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction

1995 • 427 citations

Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype

1989 • 390 citations

Interleukin‐10 prevents experimental allergic encephalomyelitis in rats

1994 • 377 citations

Review: cytokines and the pathogenesis of multiple sclerosis

1996 • 331 citations

A central role of CD40 ligand in the regulation of CD4+ T-cell responses

1996 • 329 citations

The role of IL-12 in the induction of organ-specific autoimmune diseases

1995 • 277 citations

Microglia Are More Efficient Than Astrocytes in Antigen Processing and in Th1 But Not Th2 Cell Activation

1998 • 275 citations

Microglia induce CD4 T lymphocyte final effector function and death.

1996 • 266 citations

IL-12 production by central nervous system microglia is inhibited by astrocytes.

1997 • 263 citations

Mechanisms influencing the immunodominance of T cell determinants.

1988 • 227 citations

Elevated central nervous system prostaglandins in human immunodeficiency virus—associated dementia

1994 • 226 citations

Prostaglandin E2 and Dexamethasone Inhibit IL-12 Receptor Expression and IL-12 Responsiveness

1998 • 213 citations

The Costimulatory Molecule B7 is Expressed on Human Microglia in Culture and in Multiple Sclerosis Acute Lesions

1995 • 205 citations

Prostaglandin E2 at priming of naive CD4+ T cells inhibits acquisition of ability to produce IFN-gamma and IL-2, but not IL-4 and IL-5.

1995 • 203 citations

Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)-microglobulin-deficient BALB/c mice.

1996 • 198 citations

Interleukin‐1β Induces Prostaglandin G/H Synthase‐2 (Cyclooxygenase‐2) in Primary Murine Astrocyte Cultures

1996 • 190 citations

CD40/CD40 ligand interactions are required for T cell‐dependent production of interleukin‐12 by mouse macrophages

1996 • 184 citations

Induction of Prostanoid Biosynthesis by Bacterial Lipopolysaccharide and Isoproterenol in Rat Microglial Cultures

1995 • 181 citations

Treatment of Experimental Autoimmune Encephalomyelitis with Genetically Modified Memory T Cells

1997 • 180 citations

Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor α and tumor necrosis factor β

1995 • 179 citations

Prostaglandin E₂ primes naive T cells for the production of anti‐inflammatory cytokines

1997 • 178 citations

IL-10 fails to abrogate experimental autoimmune encephalomyelitis

1996 • 169 citations

Distribution of Immunoglobulin Superfamily Members ICAM-1, -2, -3, and the β2 Integrin LFA-1 in Multiple Sclerosis Lesions

1996 • 146 citations

Astrocytes as eicosanoid‐producing cells

1988 • 122 citations

Lipopolysaccharide-induced IL-12 expression in the central nervous system and cultured astrocytes and microglia.

1997 • 112 citations

The central nervous system environment controls effector CD4⁺ T cell cytokine profile in experimental allergic encephalomyelitis

1997 • 106 citations

Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro.

1996 • 100 citations

Functional characterization of substance P receptors on cultured human spinal cord astrocytes: Synergism of substance P with cytokines in inducing interleukin-6 and prostaglandin E2 production

1997 • 95 citations

Competitive PCR quantification of pro- and anti-inflammatory cytokine mRNA in the central nervous system during autoimmune encephalomyelitis

1997 • 83 citations

IL-12 promotes enhanced recovery from vesicular stomatitis virus infection of the central nervous system.

1995 • 82 citations

Th1 cells induce and Th2 inhibit antigen-dependent IL-12 secretion by dendritic cells

1998 • 82 citations

Microglial cells qualify as the stimulators of unprimed CD4+ and CD8+ T lymphocytes in the central nervous system

1994 • 74 citations

Opposite regulation of prostaglandin E2 synthesis by transforming growth factor-β1 and interleukin 10 in activated microglial cultures

1998 • 71 citations

Selective enrichment of T_h1 CD45RB^low CD4⁺ T cells in autoimmune infiltrates in experimental allergic encephalomyelitis

1994 • 69 citations

Suppression of acute and protracted-relapsing experimental allergic encephalomyelitis by nasal administration of low-dose IL-10 in rats

1998 • 66 citations

Prostaglandins and inhibitors of arachidonate metabolism suppress experimental allergic encephalomyelitis

1994 • 65 citations

Astrocytes and Microglia Produce Interleukin-12 p40

1996 • 56 citations

Potential role of prostaglandins and leukotrienes in multiple sclerosis and experimental allergic encephalomyelitis

1992 • 48 citations

Central nervous system cytokine mRNA expression following Theiler's murine encephalomyelitis virus infection

1997 • 47 citations

Soluble protein but not peptide administration diverts the immune response of a clonal CD4+ T cell population to the T helper 2 cell pathway.

1996 • 44 citations

Tolerogenic forms of auto-antigens and cytokines in the induction of resistance to experimental allergic encephalomyelitis

1995 • 41 citations

Induction of IL-12 Gene Expression in the Brain in Septic Shock

1996 • 32 citations