Advanced sequencing technologies: methods and goals

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

The Hallmarks of Cancer

2000 • 27,569 citations

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Sequence of the Human Genome

2001 • 13,500 citations

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring

1999 • 11,586 citations

Genomic sequencing.

1984 • 8,343 citations

A new method for sequencing DNA.

1977 • 7,941 citations

The International HapMap Project

2003 • 5,951 citations

Environmental Genome Shotgun Sequencing of the Sargasso Sea

2004 • 4,313 citations

Genes required for mycobacterial growth defined by high density mutagenesis

2003 • 2,458 citations

A molecular signature of metastasis in primary solid tumors

2002 • 2,424 citations

Fluorescence detection in automated DNA sequence analysis

1986 • 1,694 citations

Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene

2003 • 1,665 citations

Prospects for whole-genome linkage disequilibrium mapping of common disease genes

1999 • 1,453 citations

Comprehensive human genome amplification using multiple displacement amplification

2002 • 1,429 citations

Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays

2000 • 1,356 citations

Zero-Mode Waveguides for Single-Molecule Analysis at High Concentrations

2003 • 1,315 citations

The Human Genome Project: Lessons from Large-Scale Biology

2003 • 1,184 citations

Blocks of Limited Haplotype Diversity Revealed by High-Resolution Scanning of Human Chromosome 21

2001 • 1,168 citations

Variation is the spice of life

2001 • 929 citations

Rules for Making Human Tumor Cells

2002 • 928 citations

DNA molecules and configurations in a solid-state nanopore microscope

2003 • 900 citations

Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations

2003 • 808 citations

Pyrosequencing Sheds Light on DNA Sequencing

2001 • 793 citations

Using the transcriptome to annotate the genome

2002 • 637 citations

Solution of a 20-Variable 3-SAT Problem on a DNA Computer

2002 • 562 citations

Phylogenetic Shadowing of Primate Sequences to Find Functional Regions of the Human Genome

2003 • 526 citations

Metabolism of Proline and the Hydroxyprolines

1980 • 510 citations

The significance of unstable chromosomes in colorectal cancer

2003 • 500 citations

Characterization of Nucleic Acids by Nanopore Analysis

2002 • 492 citations

Isolation of Antibiotics Turbomycin A and B from a Metagenomic Library of Soil Microbial DNA

2002 • 480 citations

Sequence information can be obtained from single DNA molecules

2003 • 479 citations

Microarray Deacetylation Maps Determine Genome-Wide Functions for Yeast Histone Deacetylases

2002 • 467 citations

Parallel changes in gene expression after 20,000 generations of evolution inEscherichiacoli

2003 • 457 citations

Will Genetics Revolutionize Medicine?

2000 • 411 citations

The Human Phenome Project

2003 • 372 citations

Nanopores and nucleic acids: prospects for ultrarapid sequencing

2000 • 368 citations

Investigating stem cells in human colon by using methylation patterns

2001 • 356 citations

Genetics and the making of Homo sapiens

2003 • 346 citations

Using oligonucleotide probe arrays to access genetic diversity

1999 • 345 citations

Microfabricated 384-Lane Capillary Array Electrophoresis Bioanalyzer for Ultrahigh-Throughput Genetic Analysis

2002 • 281 citations

High-Throughput Variation Detection and Genotyping Using Microarrays

2001 • 277 citations

Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility

2003 • 253 citations

In situ localized amplification and contact replication of many individual DNA molecules

1999 • 238 citations

Comparative genomics: genome-wide analysis in metazoan eukaryotes

2003 • 236 citations

SEQUENCES, SEQUENCES, AND SEQUENCES

1988 • 236 citations

Human chromosome 21 gene expression atlas in the mouse

2002 • 222 citations

The exceptional brain of Albert Einstein

1999 • 212 citations

Quality and completeness of SNP databases

2003 • 211 citations

Microfluidic devices for DNA sequencing: sample preparation and electrophoretic analysis

2003 • 196 citations

The amino-acid mutational spectrum of human genetic disease

2003 • 192 citations

Fluorescent in situ sequencing on polymerase colonies

2003 • 182 citations

Accurate sequencing by hybridization for DNA diagnostics and individual genomics

1998 • 176 citations

Digital genotyping and haplotyping with polymerase colonies

2003 • 152 citations

Selection analyses of insertional mutants using subgenic-resolution arrays

2001 • 150 citations

Alternative splicing: combinatorial output from the genome

2002 • 143 citations

TempliPhi, ⌽29 DNA Polymerase Based Rolling Circle Amplification of Templates for DNA Sequencing

2002 • 140 citations

A massively parallel PicoTiterPlate™ based platform for discrete picoliter‐scale polymerase chain reactions

2003 • 139 citations

Rates of DNA Sequence Evolution in Experimental Populations of Escherichia coli During 20,000 Generations

2003 • 134 citations

Nucleic acid aptamers in cancer medicine

2002 • 112 citations

Whole Genome Amplification of DNA from Laser Capture-Microdissected Tissue for High-Throughput Single Nucleotide Polymorphism and Short Tandem Repeat Genotyping

2004 • 102 citations

Single Molecule Profiling of Alternative Pre-mRNA Splicing

2003 • 100 citations

Highly Accurate Classification of Watson-Crick Basepairs on Termini of Single DNA Molecules

2003 • 95 citations

Long-Read Pyrosequencing Using Pure 2′-Deoxyadenosine-5′-O′-(1-thiotriphosphate) Sp-Isomer

2002 • 93 citations

Termination of DNA synthesis by novel 3'-modifieddeoxyribonucleoside 5'-triphosphates

1994 • 90 citations

DNA Sequencing and Gene Structure

1981 • 81 citations

“Iceland Inc.”?: On the ethics of commercial population genomics

2003 • 78 citations

Loss of Heterozygosity Analysis Using Whole Genome Amplification, Cell Sorting, and Fluorescence-Based PCR

1999 • 66 citations

Identification of foreign gene sequences by transcript filtering against the human genome

2002 • 63 citations

The alta summit, December 1984

1989 • 38 citations

Potential applications of DNA microarrays in biodefense-related diagnostics

2002 • 31 citations

Whole-genome amplification of DNA from residual cells left by incidental contact

2003 • 27 citations

Event-Related Potentials to Emotional and Neutral Stimuli in Alcoholism

2003 • 26 citations

The Human Genome and Other Initiatives

1990 • 25 citations

Identification of γ-aminobutyric acid transporter (GAT1) on the rat sperm

2000 • 24 citations

Unlocking hidden genomic sequence

2004 • 23 citations

DNA Sequencing by Hybridization with Arrays of Samples or Probes

2003 • 17 citations

Synthesis of Fluorescent, Photolabile 3′-O-Protected Nucleoside Triphosphates for the Base Addition Sequencing Scheme

1999 • 16 citations

Switching on Lineage Tracers Using Site-Specific Recombination

2003 • 16 citations

Getting the Bugs Worked Out

1995 • 14 citations

HGMD: The Human Gene Mutation Database

2006 • 10 citations

Gene Researchers Hunt Bargains, Fixer-Uppers

2002 • 8 citations

Snaring a venture capital investment

1998 • 5 citations

GENETICS POLICY AND LAW: A REPORT FOR POLICYMAKERS

2001 • 4 citations

Isolation of Genomic DNA from Tail Tissue

2003 • 4 citations

A cheap personal genome?

2002 • 4 citations