RNA Transport and Local Protein Synthesis in the Dendritic Compartment

The Fine Structure of the Nervous System.

1970 • 1,971 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

Conserved Structures and Diversity of Functions of RNA-Binding Proteins

1994 • 1,873 citations

Localization of ASH1 mRNA Particles in Living Yeast

1998 • 1,566 citations

Control of Memory Formation Through Regulated Expression of a CaMKII Transgene

1996 • 1,525 citations

The Fine Structure of the Nervous System: Neurons and Their Supporting Cells

1991 • 1,522 citations

Neurobiology of cerebellar evolution and development

1971 • 1,500 citations

DEVELOPMENT OF THE VERTEBRATE NEUROMUSCULAR JUNCTION

1999 • 1,485 citations

Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,458 citations

The origin of pattern and polarity in the Drosophila embryo

1992 • 1,367 citations

NEUROTROPHINS AND SYNAPTIC PLASTICITY

1999 • 1,343 citations

Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,336 citations

Rapid Spine Delivery and Redistribution of AMPA Receptors After Synaptic NMDA Receptor Activation

1999 • 1,272 citations

The Trk family of neurotrophin receptors

1994 • 1,271 citations

Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites

1995 • 1,181 citations

LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite

1999 • 964 citations

A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity

1996 • 948 citations

Rapid Actin-Based Plasticity in Dendritic Spines

1998 • 920 citations

Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas.

1986 • 896 citations

Synaptic Activation Causes the mRNA for the IEG Arc to Localize Selectively near Activated Postsynaptic Sites on Dendrites

1998 • 807 citations

Cell Type and Pathway Dependence of Synaptic AMPA Receptor Number and Variability in the Hippocampus

1998 • 798 citations

Importance of AMPA Receptors for Hippocampal Synaptic Plasticity But Not for Spatial Learning

1999 • 794 citations

Mediation by a CREB Family Transcription Factor of NGF-Dependent Survival of Sympathetic Neurons

1999 • 794 citations

Synapse-Specific, Long-Term Facilitation of Aplysia Sensory to Motor Synapses: A Function for Local Protein Synthesis in Memory Storage

1997 • 738 citations

Somatodendritic expression of an immediate early gene is regulated by synaptic activity.

1995 • 695 citations

Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity

1999 • 690 citations

Preferential localization of polyribosomes under the base of dendritic spines in granule cells of the dentate gyrus

1982 • 665 citations

Intracellular localization of messenger RNAs for cytoskeletal proteins

1986 • 639 citations

Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation

1997 • 636 citations

The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein

1993 • 632 citations

A point mutation in the FMR-1 gene associated with fragile X mental retardation

1993 • 619 citations

Three-Dimensional Organization of Smooth Endoplasmic Reticulum in Hippocampal CA1 Dendrites and Dendritic Spines of the Immature and Mature Rat

1997 • 599 citations

Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo

1999 • 579 citations

In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain

1990 • 566 citations

Selective localization of messenger RNA for cytoskeletal protein MAP2 in dendrites

1988 • 546 citations

Fragile X Mental Retardation Protein: Nucleocytoplasmic Shuttling and Association with Somatodendritic Ribosomes

1997 • 534 citations

A Transient, Neuron-Wide Form of CREB-Mediated Long-Term Facilitation Can Be Stabilized at Specific Synapses by Local Protein Synthesis

1999 • 510 citations

FMRP Associates with Polyribosomes as an mRNP, and the I304N Mutation of Severe Fragile X Syndrome Abolishes This Association

1997 • 509 citations

CPEB-Mediated Cytoplasmic Polyadenylation and the Regulation of Experience-Dependent Translation of α-CaMKII mRNA at Synapses

1998 • 485 citations

Transport and localization of exogenous myelin basic protein mRNA microinjected into oligodendrocytes.

1993 • 482 citations

Purification and characterization of a calmodulin-dependent protein kinase that is highly concentrated in brain.

1983 • 481 citations

SUBSURFACE CISTERNS AND THEIR RELATIONSHIP TO THE NEURONAL PLASMA MEMBRANE

1962 • 453 citations

Phosphorylation of elongation factor 2 by EF-2 kinase affects rate of translation

1988 • 447 citations

Sorting of β-Actin mRNA and Protein to Neurites and Growth Cones in Culture

1998 • 444 citations

Essential role for KH domains in RNA binding: Impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome

1994 • 442 citations

Staufen protein associates with the 3′UTR of bicoid mRNA to form particles that move in a microtubule-dependent manner

1994 • 435 citations

Translocation of RNA Granules in Living Neurons

1996 • 426 citations

Polarized sorting of viral glycoproteins to the axon and dendrites of hippocampal neurons in culture

1990 • 425 citations

Three‐dimensional analysis of the structure and composition of CA3 branched dendritic spines and their synaptic relationships with mossy fiber boutons in the rat hippocampus

1992 • 418 citations

Postsynaptic Membrane Fusion and Long-Term Potentiation

1998 • 417 citations

Identification of a gephyrin binding motif on the glycine receptor β subunit

1995 • 410 citations

Evidence that the major postsynaptic density protein is a component of a Ca2+/calmodulin-dependent protein kinase.

1984 • 389 citations

NMDA receptor-mediated control of protein synthesis at developing synapses

2000 • 365 citations

Distribution of glycine receptors at central synapses: an immunoelectron microscopy study.

1985 • 358 citations

RNAs from all categories generate retrosequences that may be exapted as novel genes or regulatory elements

1999 • 348 citations

Activity-Dependent Dendritic Targeting of BDNF and TrkB mRNAs in Hippocampal Neurons

1997 • 333 citations

Functional correlation of fetal and adult forms of glycine receptors with developmental changes in inhibitory synaptic receptor channels

1992 • 329 citations

The 3′-untranslated region of CaMKIIα is a cis-acting signal for the localization and translation of mRNA in dendrites

1996 • 322 citations

RNA on the move: the mRNA localization pathway [published erratum appears in J Cell Biol 1993 Dec;123(6 Pt 1):1625]

1993 • 315 citations

Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system

1993 • 313 citations

Microtubule-dependent Recruitment of Staufen-Green Fluorescent Protein into Large RNA-containing Granules and Subsequent Dendritic Transport in Living Hippocampal Neurons

1999 • 301 citations

Regulation of eukaryotic protein synthesis by initiation factors.

1993 • 300 citations

Tetanic Stimulation Leads to Increased Accumulation of Ca²⁺/Calmodulin-Dependent Protein Kinase II via Dendritic Protein Synthesis in Hippocampal Neurons

1999 • 296 citations

NMDA Receptor Content of Synapses in Stratum Radiatum of the Hippocampal CA1 Area

2000 • 294 citations

Localization of Xenopus Vg1 mRNA by Vera Protein and the Endoplasmic Reticulum

1997 • 287 citations

Brain-derived neurotrophic factor rapidly enhances phosphorylation of the postsynaptic N -methyl- <scp>d</scp> -aspartate receptor subunit 1

1997 • 286 citations

Calcium-induced calcium release in cerebellar purkinje cells

1994 • 279 citations

Localized Sources of Neurotrophins Initiate Axon Collateral Sprouting

1998 • 277 citations

Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain.

1996 • 273 citations

Lupus autoantibodies target ribosomal P proteins.

1985 • 272 citations

The Mammalian Staufen Protein Localizes to the Somatodendritic Domain of Cultured Hippocampal Neurons: Implications for Its Involvement in mRNA Transport

1999 • 272 citations

Neurotrophin release by neurotrophins: Implications for activity-dependent neuronal plasticity

1997 • 268 citations

Requirement of Microfilaments in Sorting of Actin Messenger RNA

1991 • 252 citations

mRNA Localization in Neurons: A Multipurpose Mechanism?

1997 • 248 citations

Metabotropic glutamate receptors trigger postsynaptic protein synthesis.

1993 • 246 citations

Mammalian Staufen Is a Double-Stranded-RNA- and Tubulin-Binding Protein Which Localizes to the Rough Endoplasmic Reticulum

1999 • 244 citations

Diversity of cytoplasmic functions for the 3′ untranslated region of eukaryotic transcripts

1995 • 241 citations

Dendritic location of neural BC1 RNA.

1991 • 231 citations

Dendritic and Postsynaptic Protein Synthetic Machinery

1999 • 228 citations

RNA-RNA interaction is required for the formation of specific bicoid mRNA 3' UTR-STAUFEN ribonucleoprotein particles

1997 • 221 citations

Protein translation components are colocalized in granules in oligodendrocytes

1995 • 215 citations

Selective dendritic transport of RNA in hippocampal neurons in culture

1987 • 214 citations

Translational Machinery in Dendrites of Hippocampal Neurons in Culture

1996 • 206 citations

Neurotrophin Regulation of β-Actin mRNA and Protein Localization within Growth Cones

1999 • 202 citations

Molecular Insights into mRNA Transport and Local Translation in the Mammalian Nervous System

2000 • 202 citations

Widespread expression of inositol 1,4,5-trisphosphate receptor type 1 gene (Insp3r1) in the mouse central nervous system.

1993 • 201 citations

Differential subcellular localization of particular mRNAs in hippocampal neurons in culture

1990 • 201 citations

Ca2+ stores in Purkinje neurons: endoplasmic reticulum subcompartments demonstrated by the heterogeneous distribution of the InsP3 receptor, Ca(2+)-ATPase, and calsequestrin

1992 • 200 citations

Heterogeneous distribution of the cAMP receptor protein RII in the nervous system: evidence for its intracellular accumulation on microtubules, microtubule-organizing centers, and in the area of the Golgi complex.

1986 • 197 citations

Demonstration of local protein synthesis within dendrites using a new cell culture system that permits the isolation of living axons and dendrites from their cell bodies.

1992 • 197 citations

CaMKII regulates the density of central glutamatergic synapses in vivo

1999 • 196 citations

Functional expression in Xenopus oocytes of the strychnine binding 48 kd subunit of the glycine receptor.

1989 • 192 citations

Dendritic spine formation and pruning: common cellular mechanisms?

2000 • 191 citations

Evidence that protein constituents of postsynaptic membrane specializations are locally synthesized: analysis of proteins synthesized within synaptosomes

1991 • 191 citations

Release of calcium from stores alters the morphology of dendritic spines in cultured hippocampal neurons

1999 • 189 citations

Protein Synthesis within Dendrites: Glycosylation of Newly Synthesized Proteins in Dendrites of Hippocampal Neurons in Culture

1996 • 189 citations

Ion-channel assembly.

1995 • 181 citations

Demonstration of local protein synthesis within dendrites using a new cell culture system that permits the isolation of living axons and dendrites from their cell bodies

1992 • 174 citations

Identification of acis-Acting Dendritic Targeting Element in MAP2 mRNAs

1999 • 174 citations

Protein-synthetic machinery at postsynaptic sites during synaptogenesis: a quantitative study of the association between polyribosomes and developing synapses

1986 • 172 citations

Sorting of membrane proteins in the secretory pathway

1993 • 171 citations

A Human Sequence Homologue of Staufen Is an RNA-Binding Protein That Is Associated with Polysomes and Localizes to the Rough Endoplasmic Reticulum

1999 • 169 citations

Postsynaptic Target Specificity of Neurotrophin-Induced Presynaptic Potentiation

2000 • 167 citations

Differential Intracellular Sorting of Immediate Early Gene mRNAs Depends on Signals in the mRNA Sequence

1998 • 167 citations

Glutamate-dependent phosphorylation of elongation factor-2 and inhibition of protein synthesis in neurons.

1997 • 163 citations

Glutamate-Dependent Phosphorylation of Elongation Factor-2 and Inhibition of Protein Synthesis in Neurons

1997 • 159 citations

The travels of mRNAs through all cells large and small

1999 • 157 citations

Ultrastructural visualization of cytoskeletal mRNAs and their associated proteins using double-label in situ hybridization.

1989 • 157 citations

Intracellular Ca2+ stores in chicken Purkinje neurons: differential distribution of the low affinity-high capacity Ca2+ binding protein, calsequestrin, of Ca2+ ATPase and of the ER lumenal protein, Bip.

1991 • 156 citations

RNA–cytoskeletal associations

1999 • 151 citations

Localization of Cellular Storage Compartments and Sites of Constitutive and Activity-Dependent Release of Nerve Growth Factor (NGF) in Primary Cultures of Hippocampal Neurons

1996 • 151 citations

Primary cultures of mouse spinal cord express the neonatal isoform of the inhibitory glycine receptor

1989 • 151 citations

Ca²⁺/calmodulin‐dependent phosphorylation of elongation factor 2

1987 • 150 citations

Presence and phosphorylation of transcription factors in developing dendrites

1998 • 149 citations

Axon/Dendrite Targeting of Metabotropic Glutamate Receptors by Their Cytoplasmic Carboxy-Terminal Domains

1999 • 148 citations

RNA Transport in Dendrites: Acis-Acting Targeting Element Is Contained within Neuronal BC1 RNA

1997 • 146 citations

Ion-channel assembly

1995 • 143 citations

Golgi apparatus in chick skeletal muscle: changes in its distribution during end plate development and after denervation.

1989 • 140 citations

mRNA at the synapse: analysis of a synaptosomal preparation enriched in hippocampal dendritic spines

1993 • 139 citations

Neural BC1 RNA: cDNA clones reveal nonrepetitive sequence content.

1987 • 138 citations

Calcium Depletion from the Endoplasmic Reticulum Activates the Double-stranded RNA-dependent Protein Kinase (PKR) to Inhibit Protein Synthesis

1995 • 134 citations

Distinct spatial localization of specific mRNAs in cultured sympathetic neurons

1990 • 132 citations

Activation of the Double-stranded RNA-regulated Protein Kinase by Depletion of Endoplasmic Reticular Calcium Stores

1995 • 126 citations

Translocation machinery for synthesis of integral membrane and secretory proteins in dendritic spines

2000 • 125 citations

Structure and Functions of Inhibitory and Excitatory Glycine Receptors

1999 • 123 citations

Modulation of the Kv1.3 Potassium Channel by Receptor Tyrosine Kinases

1997 • 121 citations

Neurotrophin Modulation of NMDA Receptors in Cultured Murine and Isolated Rat Neurons

1997 • 120 citations

Localization of the small GTP-binding protein rab1p to early compartments of the secretory pathway

1995 • 116 citations

Calcium-Evoked Dendritic Exocytosis in Cultured Hippocampal Neurons. Part I: Trans-Golgi Network-Derived Organelles Undergo Regulated Exocytosis

1998 • 111 citations

Differential Subcellular Regulation of NMDAR1 Protein and mRNA in Dendrites of Dentate Gyrus Granule Cells after Perforant Path Transection

1997 • 108 citations

A SUGGESTIVE RELATIONSHIP OF NERVE CELL RNA WITH SPECIFIC SYNAPTIC SITES

1965 • 107 citations

RNA sorting inXenopusoocytes and embryos

1999 • 106 citations

Dendritic and Postsynaptic Localizations of Glycine Receptor α Subunit mRNAs

1997 • 105 citations

Neurotrophins as in vitro growth cone guidance molecules for embryonic sensory neurons

1997 • 104 citations

Development of subcellular mRNA compartmentation in hippocampal neurons in culture

1994 • 98 citations

Activity-dependent Regulation of Dendritic BC1 RNA in Hippocampal Neurons in Culture

1998 • 97 citations

Neural Science

2000 • 91 citations

Lamina-Specific Synaptic Activation Causes Domain-Specific Alterations in Dendritic Immunostaining for MAP2 and CAM Kinase II

1999 • 90 citations

Nerve growth factor regulates the abundance and distribution of K+ channels in PC12 cells.

1993 • 81 citations

Calcium-Evoked Dendritic Exocytosis in Cultured Hippocampal Neurons. Part II: Mediation by Calcium/Calmodulin-Dependent Protein Kinase II

1998 • 80 citations

The identity of the calcium-storing, inositol 1,4,5—trisphosphate-sensitive organelle in non-muscle cells: calciosome, endoplasmic reticulum … or both?

1991 • 80 citations

Differential Distribution of Intracellular Glutamate Receptors in Dendrites

1999 • 78 citations

Activity-Dependent Calcium Sequestration in Dendrites of Hippocampal Neurons in Brain Slices

1997 • 77 citations

RNA sorting inDrosophilaoocytes and embryos

1999 • 77 citations

Independent Signaling of grp78 Gene Transcription and Phosphorylation of Eukaryotic Initiation Factor 2α by the Stressed Endoplasmic Reticulum

1995 • 72 citations

N -methyl- <scp>d</scp> -aspartate receptor activation and visual activity induce elongation factor-2 phosphorylation in amphibian tecta: A role for N -methyl- <scp>d</scp> -aspartate receptors in controlling protein synthesis

1997 • 70 citations

Regulation of voltage-gated ion channels by NGF and ciliary neurotrophic factor in SK-N-SH neuroblastoma cells

1995 • 69 citations

Subcellular RNA compartmentalization

1999 • 65 citations

Dendritic Localization of Rat Vasopressin mRNA: Ultrastructural Analysis and Mapping of Targeting Elements

1997 • 60 citations

Long-term Facilitation in Aplysia: Persistent Phosphorylation and Structural Changes

1990 • 59 citations

No evidence for disruption of normal patterns of mRNA localization in dendrites or dendritic transport of recently synthesized mRNA in FMR1 knockout mice, a model for human fragile-X mental retardation syndrome

1998 • 59 citations

The BC200 RNA Gene and Its Neural Expression Are Conserved in Anthropoidea (Primates)

1998 • 56 citations

Ultrastructural Localization of Dendritic Messenger RNA in Adult Rat Hippocampus

1996 • 53 citations

Polyribosomes under developing spine synapses: Growth specializations of dendrites at sites of synaptogenesis

1985 • 52 citations

Pharmacological Evidence for Two Types of Postsynaptic Glycinergic Receptors on the Mauthner Cell of 52-h-Old Zebrafish Larvae

1997 • 52 citations

Transport of BC1 RNA in hypothalamo-neurohypophyseal axons

1993 • 48 citations

Modulation of a voltage-activated potassium channel by peptide growth factor receptors

1994 • 48 citations

Polarized Distribution of the Trans‐Golgi Network Marker TGN38 During the In Vitro Development of Neocortical Neurons: Effects of Nocodazole and Brefeldin A

1994 • 43 citations

PARANEOPLASTIC SYNDROMES AFFECTING THE CENTRAL NERVOUS SYSTEM

1997 • 40 citations

Ribosome Association Contributes to Restricting mRNAs to the Cell Body of Hippocampal Neurons

1998 • 38 citations

Epitope mapping of two isoforms of a trans Golgi network specific integral membrane protein TGN38/41

1992 • 36 citations

Spatial features of calcium‐regulated gene expression

1997 • 36 citations

Inhibition of protein synthesis alters the subcellular distribution of mRNA in neurons but does not prevent dendritic transport of RNA.

1993 • 34 citations

Visinin-like Protein (VILIP) Is a Neuron-specific Calcium-dependent Double-stranded RNA-binding Protein

1999 • 33 citations

Calcium channel activation stabilizes a neuronal calcium channel mRNA

1999 • 33 citations

Subcellular distribution of rRNA and poly(A) RNA in hippocampal neurons in culture

1993 • 31 citations

Differential expression of the metabotropic glutamate receptor mGluR1? by neurons and axons in the cochlear nucleus: In situ hybridization and immunohistochemistry

1998 • 30 citations

Nerve‐Dependent Plasticity of the Golgi Complex in Skeletal Muscle Fibres: Compartmentalization Within the Subneural Sarcoplasm

1995 • 29 citations

Chapter 22 Regulation of synaptogenesis through the local synthesis of protein at the postsynaptic site

1987 • 28 citations

Molecular characterization of dendritically localized transcripts encoding MAP2

1996 • 25 citations

Calcium Ion Impedes Translation Initiation at the Synapse

1996 • 16 citations