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1986 • 1,283 citations

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1998 • 1,255 citations

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

1976 • 1,247 citations

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines

2002 • 1,009 citations

Calcium: still center-stage in hypoxic-ischemic neuronal death

1995 • 921 citations

Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia

1997 • 866 citations

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

1995 • 843 citations

Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids

1976 • 832 citations

A YAC Mouse Model for Huntington’s Disease with Full-Length Mutant Huntingtin, Cytoplasmic Toxicity, and Selective Striatal Neurodegeneration

1999 • 831 citations

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

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A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length

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Mitochondrial defect in Huntington's disease caudate nucleus

1996 • 737 citations

Inactivation of the Mouse Huntington's Disease Gene Homolog Hdh

1995 • 705 citations

Increased Sensitivity to N-Methyl-D-Aspartate Receptor-Mediated Excitotoxicity in a Mouse Model of Huntington's Disease

2002 • 603 citations

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Chronic quinolinic acid lesions in rats closely resemble Huntington's disease

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Huntingtin and Huntingtin-Associated Protein 1 Influence Neuronal Calcium Signaling Mediated by Inositol-(1,4,5) Triphosphate Receptor Type 1

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1993 • 411 citations

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Huntington's disease gene (IT15) is widely expressed in human and rat tissues

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Mutant Huntingtin Enhances Excitotoxic Cell Death

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Subtype‐Specific Enhancement of NMDA Receptor Currents by Mutant Huntingtin

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Differential expression of mGluR5 metabotropic glutamate receptor mRNA by rat striatal neurons

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A primate model of Huntington's disease: Behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon

1990 • 177 citations

Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease

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1998 • 174 citations

N‐Methyl‐<scp>d</scp>‐Aspartate Receptor Proteins NR2A and NR2B Are Differentially Distributed in the Developing Rat Central Nervous System as Revealed by Subunit‐Specific Antibodies

1996 • 153 citations

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1997 • 120 citations

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Expression of Polyglutamine-expanded Huntingtin Induces Tyrosine Phosphorylation of N-Methyl-D-aspartate Receptors

2003 • 94 citations

Glutamate Cascade to cAMP Response Element-Binding Protein Phosphorylation in Cultured Striatal Neurons through Calcium-Coupled Group I Metabotropic Glutamate Receptors

2002 • 68 citations

Huntingtin: Alive and Well and Working in Middle Management

2003 • 55 citations

Upregulation of preprodynorphin and preproenkephalin mRNA expression by selective activation of group I metabotropic glutamate receptors in characterized primary cultures of rat striatal neurons

2001 • 50 citations

Loss of endoplasmic reticulum-associated enzymes in affected brain regions in Huntington's disease and Alzheimer-type dementia

1985 • 15 citations

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