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Clinical significance and regulation of the costimulatory molecule B7-H1 in pancreatic cancer

Data up to Jan 2025

Published2008
Citations133
References57

Total Citations Per Year

Abstract

References (57)

Cancer Statistics, 2008

2008 • 10,165 citations

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

2002 • 4,625 citations

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

1992 • 2,906 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

A Randomized Trial of Chemoradiotherapy and Chemotherapy after Resection of Pancreatic Cancer

2004 • 2,588 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

The B7–CD28 superfamily

2002 • 1,646 citations

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

2003 • 1,564 citations

Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity

2003 • 1,255 citations

Pancreatic Carcinoma

1992 • 1,175 citations

CTLA-4: new insights into its biological function and use in tumor immunotherapy

2002 • 923 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

Clinical Significance and Therapeutic Potential of the Programmed Death-1 Ligand/Programmed Death-1 Pathway in Human Pancreatic Cancer

2007 • 843 citations

Tumor B7-H1 Is Associated with Poor Prognosis in Renal Cell Carcinoma Patients with Long-term Follow-up

2006 • 826 citations

Pancreatic cancer: a report of treatment and survival trends for 100,313 patients diagnosed from 1985–1995, using the National Cancer Database11No competing interests declared.

1999 • 786 citations

Clinical Significance of Programmed Death-1 Ligand-1 and Programmed Death-1 Ligand-2 Expression in Human Esophageal Cancer

2005 • 758 citations

Prevalence of FOXP3+ Regulatory T Cells Increases During the Progression of Pancreatic Ductal Adenocarcinoma and Its Premalignant Lesions

2006 • 746 citations

Does the Immune System See Tumors as Foreign or Self?

2003 • 746 citations

Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target

2004 • 742 citations

B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity

2003 • 665 citations

B7-H1 Expression on Non-Small Cell Lung Cancer Cells and Its Relationship with Tumor-Infiltrating Lymphocytes and Their PD-1 Expression

2004 • 664 citations

Identification of human cancers deficient in antigen processing.

1993 • 625 citations

The B7-H1 (PD-L1) T Lymphocyte-Inhibitory Molecule Is Expressed in Breast Cancer Patients with Infiltrating Ductal Carcinoma: Correlation with Important High-Risk Prognostic Factors

2006 • 570 citations

Tumor Regression and Autoimmunity in Patients Treated With Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Interleukin 2: A Phase I/II Study

2005 • 486 citations

Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance

2006 • 474 citations

PD-1: an inhibitory immunoreceptor involved in peripheral tolerance

2001 • 467 citations

Interferon regulatory factor‐1 is prerequisite to the constitutive expression and IFN‐γ‐induced upregulation of B7‐H1 (CD274)

2006 • 413 citations

A Pilot Trial of CTLA-4 Blockade with Human Anti-CTLA-4 in Patients with Hormone-Refractory Prostate Cancer

2007 • 397 citations

Cytokines in pancreatic carcinoma

2004 • 295 citations

Blockade of PD‐L1 (B7‐H1) augments human tumor‐specific T cell responses in vitro

2006 • 292 citations

Systemic and local immunosuppression in pancreatic cancer patients.

2001 • 277 citations

B7-H1 pathway and its role in the evasion of tumor immunity

2003 • 272 citations

Immune Suppression in the Tumor Microenvironment

2006 • 259 citations

Tumor-Associated Transforming Growth Factor-β and Interleukin-10 Contribute to a Systemic Th2 Immune Phenotype in Pancreatic Carcinoma Patients

1999 • 227 citations

Invasion and metastasis in pancreatic cancer.

2003 • 216 citations

CTLA-4 and T cell activation

1999 • 209 citations

Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis

2005 • 207 citations

Immunotherapy for pancreatic cancer — science driving clinical progress

2005 • 197 citations

FOXP3+ Tregs and B7-H1+/PD-1+T lymphocytes co-infiltrate the tumor tissues of high-risk breast cancer patients: Implication for immunotherapy

2008 • 194 citations

The New B7s: Playing a Pivotal Role in Tumor Immunity

2007 • 188 citations

Expression of HLA-A,B,C antigens on primary and metastatic tumor cell populations of human carcinomas.

1991 • 160 citations

The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells

2004 • 160 citations

An Overview of the Interferon System: Signal Transduction and Mechanisms of Action

1996 • 142 citations

B7DC/PDL2 Promotes Tumor Immunity by a PD-1–independent Mechanism

2003 • 141 citations

Pancreatic Cancer

2006 • 127 citations

Expression of Functional B7-H2 and B7.2 Costimulatory Molecules and Their Prognostic Implications inDe novoAcute Myeloid Leukemia

2005 • 114 citations

Accelerated chemically induced tumor development mediated by CD4 + CD25 + regulatory T cells in wild-type hosts

2005 • 111 citations

IFN-Dependent Down-Regulation of the NKG2D Ligand H60 on Tumors

2006 • 101 citations

Combined GM-CSF and IL-12 gene therapy synergistically suppresses the growth of orthotopic liver tumors

2007 • 62 citations

An Important Role of CD80/CD86-CTLA-4 Signaling during Photocarcinogenesis in Mice

2005 • 53 citations

Surgical treatment of pancreatic cancer: The role of adjuvant and multimodal therapies

2007 • 35 citations

Therapeutic opportunities in the B7/CD28 family of ligands and receptors

2005 • 31 citations

B7-1 expression by a non-antigen presenting cell-derived tumor.

1995 • 27 citations

B7molecule mRNA expression in colorectal carcinoma

2005 • 11 citations

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Clinical significance and regulation of the costimulatory molecule B7-H1 in pancreatic… (2008) – Cancer Letters | Metascience Observatory Explorer