T Cell Response to Mycobacterium tuberculosis

Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.

1983 • 1,918 citations

A Prospective Study of the Risk of Tuberculosis among Intravenous Drug Users with Human Immunodeficiency Virus Infection

1989 • 1,587 citations

Tuberculosis: Commentary on a Reemergent Killer

1992 • 1,400 citations

Differing Lymphokine Profiles of Functional Subsets of Human CD4 and CD8 T Cell Clones

1991 • 1,027 citations

Heat shock proteins and the immune response

1990 • 944 citations

An Outbreak of Multidrug-Resistant Tuberculosis among Hospitalized Patients with the Acquired Immunodeficiency Syndrome

1992 • 909 citations

Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection.

1992 • 771 citations

Lymphocyte interactions with endothelial cells

1992 • 689 citations

Tuberculosis in developing countries: burden, intervention and cost.

1990 • 600 citations

Isolation of CD4-CD8-mycobacteria-reactive T lymphocyte clones from rheumatoid arthritis synovial fluid

1989 • 543 citations

Stimulation of a major subset of lymphocytes expressing T cell receptor γδ by an antigen derived from mycobacterium tuberculosis

1989 • 491 citations

Human γδ+ T cells respond to mycobacterial heat-shock protein

1989 • 417 citations

Tumor necrosis factor, alone or in combination with IL-2, but not IFN-gamma, is associated with macrophage killing of Mycobacterium avium complex.

1988 • 378 citations

PROTEIN SECRETION IN ESCHERICHIA COLI

1985 • 334 citations

A large fraction of human peripheral blood gamma/delta + T cells is activated by Mycobacterium tuberculosis but not by its 65-kD heat shock protein.

1990 • 331 citations

Isolation and partial characterization of major protein antigens in the culture fluid of Mycobacterium tuberculosis

1991 • 319 citations

Gamma interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria

1985 • 315 citations

T Cells Against a Bacterial Heat Shock Protein Recognize Stressed Macrophages

1989 • 310 citations

Recognition of a Peptide Antigen by Heat Shock--reactive γδ T Lymphocytes

1990 • 291 citations

Delayed-type hypersensitivity and cell-mediated immunity in the pathogenesis of tuberculosis

1991 • 288 citations

Selection of a human T helper type 1-like T cell subset by mycobacteria.

1991 • 281 citations

Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis.

1991 • 277 citations

Characterization of fibronectin-binding antigens released by Mycobacterium tuberculosis and Mycobacterium bovis BCG

1988 • 268 citations

T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. Evidence for different kinetics and recognition of a wide spectrum of protein antigens.

1992 • 256 citations

Recognition of heat shock proteins and γΔ cell function

1990 • 247 citations

Induction of nonspecific acquired resistance and delayed-type hypersensitivity, but not specific acquired resistance in mice inoculated with killed mycobacterial vaccines

1988 • 245 citations

Primary responses of human T cells to mycobacteria: a frequent set of γ/δ T cells are stimulated by protease‐resistant ligands

1990 • 243 citations

T lymphocytes from healthy individuals with specificity to self-epitopes shared by the mycobacterial and human 65-kilodalton heat shock protein.

1989 • 237 citations

Structural basis of capacity of lipoarabinomannan to induce secretion of tumor necrosis factor

1992 • 222 citations

Enumeration of T cells reactive with Mycobacterium tuberculosis organisms and specific for the recombinant mycobacterial 64‐kDa protein

1987 • 216 citations

Late dominance of the inflammatory process in murine influenza by gamma/delta + T cells.

1990 • 213 citations

Characteristics and specificity of acquired immunologic memory to Mycobacterium tuberculosis infection.

1988 • 207 citations

Properties of proteins MPB64, MPB70, and MPB80 of Mycobacterium bovis BCG

1986 • 200 citations

Protection against Mycobacterium tuberculosis infection by adoptive immunotherapy. Requirement for T cell-deficient recipients.

1983 • 196 citations

Structure and mapping of antigenic domains of protein antigen b, a 38,000-molecular-weight protein of Mycobacterium tuberculosis

1989 • 187 citations

Lipoarabinomannan from Mycobacterium tuberculosis induces the production of tumour necrosis factor from human and murine macrophages.

1989 • 185 citations

Mycobacteria‐reactive Lyt‐2⁺ T cell lines

1988 • 175 citations

T-cell proliferative response to antigens secreted by Mycobacterium tuberculosis

1991 • 174 citations

Infection breaks T-cell tolerance

1992 • 174 citations

Defective interleukin 2 production and responsiveness in human pulmonary tuberculosis.

1986 • 172 citations

Cloning and expression of the Mycobacterium bovis BCG gene for extracellular alpha antigen

1988 • 171 citations

Target cell lysis and IL-2 secretion by gamma/delta T lymphocytes after activation with bacteria.

1990 • 167 citations

Induction of interleukin 1 and tumor necrosis factor by mycobacterial proteins: the monocyte western blot.

1990 • 160 citations

The λδ T cell receptor and class lb MHC-related proteins: Enigmatic molecules of immune recognition

1989 • 150 citations

Results of a World Health Organization-sponsored workshop to characterize antigens recognized by mycobacterium-specific monoclonal antibodies

1986 • 150 citations

The relationship of delayed hypersensitivity to acquired antituberculous immunity

1970 • 146 citations

Protein secretion in gram-negative bacteria: transport across the outer membrane involves common mechanisms in different bacteria.

1990 • 139 citations

Selective expansion of human gamma delta T cells by monocytes infected with live Mycobacterium tuberculosis.

1991 • 138 citations

The Significance of the Tuberculin Skin Test in Elderly Persons

1987 • 136 citations

Early appearing gamma/delta-bearing T cells during infection with Calmétte Guérin bacillus.

1991 • 133 citations

The Secreted Antigens of Mycobacterium tuberculosis and Their Relationship to Those Recognized by the Available Antibodies

1988 • 128 citations

Transfer of Adoptive Immunity to Tuberculosis in Mice

1975 • 128 citations

Specificity of a protective memory immune response against Mycobacterium tuberculosis

1993 • 111 citations

Human T cell clones recognize two abundant Mycobacterium tuberculosis protein antigens expressed in Escherichia coli.

1987 • 101 citations

Identification of Immunodominant Antigens during Infection with Mycobacterium tuberculosis

1992 • 97 citations

A localization index for distinction between extracellular and intracellular antigens of Mycobacterium tuberculosis

1991 • 96 citations

Superoxide Dismutase from Mycobacterium tuberculosis

1976 • 96 citations

Role of the mononuclear phagocyte as an antigen-presenting cell for human gamma delta T cells activated by live Mycobacterium tuberculosis

1992 • 95 citations

A Mouse Model of the Recrudescence of Latent Tuberculosis in the Elderly

1988 • 88 citations

Structure and function of a 40,000-molecular-weight protein antigen of Mycobacterium tuberculosis

1992 • 88 citations

Immunoreactivity of a 10-kDa antigen of Mycobacterium tuberculosis.

1992 • 85 citations

Specific lysis of mycobacterial antigen-bearing macrophages by class II MHC-restricted polyclonal T cell lines in healthy donors or patients with tuberculosis

1990 • 85 citations

IFN-gamma-producing ability as a possible marker for the protective T cells against Mycobacterium bovis BCG in mice.

1992 • 79 citations

Characterization of antibody-reactive epitopes on the 65-kilodalton protein of Mycobacterium leprae

1987 • 77 citations

Analysis of the functional capabilities of CD3+CD4-CD8- and CD3+CD4+CD8+ human T cell clones.

1989 • 72 citations

Production of granulocyte-macrophage colony-stimulating factor (GM-CSF) by monocytes and large granular lymphocytes stimulated with Mycobacterium avium-M. intracellulare: activation of bactericidal activity by GM-CSF

1991 • 71 citations

Evidence for three separate genes encoding the proteins of the mycobacterial antigen 85 complex

1990 • 69 citations

T-Cells, Stress Proteins, and Pathogenesis of Mycobacterial Infections

1990 • 68 citations

Antigens in culture supernatant of Mycobacterium tuberculosis: epitopes defined by monoclonal and human antibodies

1990 • 63 citations

Evidence that Protein Antigen b of Mycobacterium Tuberculosis is Involved in Phosphate Metabolism

1990 • 63 citations

Function and antigen recognition pattern of L3T4+ T-cell clones from Mycobacterium tuberculosis-immune mice

1986 • 60 citations

Genes for the major protein antigens of Mycobacterium tuberculosis: the etiologic agents of tuberculosis and leprosy share an immunodominant antigen.

1987 • 59 citations

BCG induced CD4+ cytotoxic T cells from BCG vaccinated healthy subjects: relation between cytotoxicity and suppression in vitro.

1987 • 57 citations

The immunology of tuberculous pleurisy.

1988 • 48 citations

In vivo and in vitro characterization of murine T-cell clones reactive to Mycobacterium tuberculosis

1987 • 47 citations

The mycobacterial 65 kD heat-shock protein and autoimmune arthritis

1989 • 46 citations

The effects of the AIDS epidemic on the tuberculosis problem and tuberculosis programmes.

1988 • 44 citations

Responsiveness to live M. tuberculosis, and common antigens, of sonicate-stimulated T cell lines from normal donors.

1986 • 42 citations

Evaluation of the Protective Potency of New Tuberculosis Vaccines

1989 • 40 citations

Effect of Zinc Deficiency on the Appearance of Two Immunodominant Protein Antigens (32 kDa and 65 kDa) in Culture Filtrates of Mycobacteria

1989 • 36 citations

Heat-shock proteins and pathogenesis of bacterial infections

1991 • 32 citations

Monoclonal antibodies produced in BALB.B10 mice define new antigenic determinants in culture filtrate preparations of Mycobacterium tuberculosis

1988 • 32 citations

Functional analysis in vitro and in vivo of Mycobacterium bovis strain BCG-specific T cell clones.

1986 • 30 citations

Dissociation between delayed-type hypersensitivity and resistance to pathogenic mycobacteria demonstrated by T-cell clones

1987 • 30 citations

Immunological memory in tuberculosis

1978 • 26 citations

The immunology of anti-tuberculous immunity.

1968 • 26 citations

The immune response to the cell wall of Mycobacterium bovis BCG.

1988 • 17 citations

Inhibition of growth of Mycobacterium avium in murine and human mononuclear phagocytes by migration inhibitory factor

1993 • 15 citations

Evidence for a biphasic memory T-cell response to high dose BCG vaccination in mice

1988 • 14 citations

The tuberculin test and the diagnosis of clinical tuberculosis.

1960 • 12 citations

THE STEADY STATE IN CELLULAR IMMUNITY

1967 • 12 citations

Passive transfer of tuberculin sensitivity from anergic mice

1984 • 11 citations

T cell response in acquired protective immunity to Mycobacterium tuberculosis infection.

1991 • 7 citations

Deleted Work

1955 • 0 citations