TREATMENT CHANGES IN PROSTATIC HYPERPLASIA AND CANCER, INCLUDING ANDROGEN DEPRIVATION THERAPY AND RADIOTHERAPY

In vivo amplification of the androgen receptor gene and progression of human prostate cancer

1995 • 1,464 citations

The Effect of Finasteride in Men with Benign Prostatic Hyperplasia

1992 • 1,111 citations

Leuprolide versus Diethylstilbestrol for Metastatic Prostate Cancer

1984 • 612 citations

Detection of the apoptosis-suppressing oncoprotein bc1-2 in hormone-refractory human prostate cancers.

1993 • 597 citations

The effect of local control on metastatic dissemination in carcinoma of the prostate: Long-term results in patients treated with 1251 implantation

1991 • 462 citations

Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. Specificity for steroids and antihormones.

1992 • 430 citations

Genetic alterations in untreated metastases and androgen-independent prostate cancer detected by comparative genomic hybridization and allelotyping.

1996 • 398 citations

Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.

1996 • 393 citations

Correlation of Prostate Needle Biopsy and Radical Prostatectomy Gleason Grade in Academic and Community Settings

1997 • 374 citations

Urologic Surgical Pathology

2020 • 367 citations

New approach in the treatment of prostate cancer: Complete instead of partial withdrawal of androgens

1983 • 296 citations

Correlation with Grade in 316 Matched Prostatectomies

1994 • 291 citations

CG island methylation changes near the GSTP1 gene in prostatic intraepithelial neoplasia.

1998 • 280 citations

Active cell death in hormone-dependent tissues

1992 • 264 citations

Correlation between Gleason Score of Needle Biopsy and Radical Prostatectomy Specimen: Accuracy and Clinical Implications

1997 • 250 citations

Finasteride

1994 • 229 citations

The clinical development of a 5α-reductase inhibitor, finasteride

1990 • 221 citations

Androgen receptor gene expression in human prostate carcinoma cell lines.

1990 • 220 citations

Atypical adenomatous hyperplasia of the prostate: Morphologic criteria for its distinction from well-differentiated carcinoma

1993 • 219 citations

Atypical Small Acinar Proliferation Suspicious for Malignancy in Prostate Needle Biopsies

1997 • 207 citations

Molecular biology of prostatic intraepithelial neoplasia

1996 • 207 citations

The extent and multicentricity of high-grade prostatic intraepithelial neoplasia in clinically localized prostatic adenocarcinoma

1997 • 187 citations

Diagnostic criteria of limited adenocarcinoma of the prostate on needle biopsy

1995 • 182 citations

Hormone-refractory (D3) prostate cancer: Refining the concept

1995 • 181 citations

Finasteride (MK‐906) in the treatment of benign prostatic hyperplasia

1993 • 170 citations

Grading prostate cancer.

1994 • 164 citations

Radiation injury of the normal and neoplastic prostate

1982 • 162 citations

Pathologic changes associated with androgen deprivation therapy for prostate cancer

1991 • 161 citations

Boost treatment of the prostate using shaped, fixed fields

1989 • 159 citations

Effect of Neoadjuvant Endocrine Therapy (Combined Androgen Blockade) on Normal Prostate and Prostatic Carcinoma

1996 • 151 citations

The Focus of “Atypical Glands, Suspicious for Malignancy” in Prostatic Needle Biopsy Specimens:Incidence, Histologic Features, and Clinical Follow-Up of Cases Diagnosed in a Community Practice

1997 • 148 citations

Diagnosis of “Suspicious for Malignancy” in Prostate Biopsies: Predictive Value for Cancer

1998 • 147 citations

Design of the Prostate Cancer Prevention Trial (PCPT)

1995 • 135 citations

Clinical and Pathobiological Effects of Neoadjuvant Total Androgen Ablation Therapy on Clinically Localized Prostatic Adenocarcinoma

1994 • 134 citations

The influence of local control on metastatic dissemination of prostate cancer treated by external beam megavoltage radiation therapy

1991 • 130 citations

Effect of Combination Endocrine Therapy (LHRH Agonist and Flutamide) on Normal Prostate and Prostatic Adenocarcinoma

1991 • 129 citations

The Effect of Finasteride on Prostate Specific Antigen: Review of Available Data

1996 • 128 citations

The national cancer data base report on race, age, and region variations in prostate cancer treatment

1997 • 126 citations

Evaluation of radiation effect, tumor differentiation, and prostate specific antigen staining in sequential prostate biopsies after external beam radiotherapy for patients with prostate carcinoma

1997 • 122 citations

Treatment with finasteride following radical prostatectomy for prostate cancer

1995 • 121 citations

Gleason histologic grading of prostatic carcinoma. Correlations between biopsy and prostatectomy specimens

1986 • 121 citations

Salvage surgery for radiation failure in prostate cancer

1993 • 119 citations

Growth factors and oncogenes in prostate cancer.

1990 • 115 citations

Residual disease after radical surgery or radiation therapy for prostate cancer. Clinical significance and therapeutic implications

1993 • 114 citations

Pathology of the Prostate

1998 • 114 citations

Decrease of prostatic intraepithelialneoplasia following androgen deprivation therapy in patients with stage T3 carcinoma treated by radical prostatectomy

1994 • 114 citations

Accuracy of Biopsy Gleason Scores from a Large Uropathology Laboratory: Use of a Diagnostic Protocol to Minimize Observer Variability

1998 • 110 citations

Gleason histologic grading in prostatic carcinoma. Correlation of 18-gauge core biopsy with prostatectomy.

1994 • 108 citations

Pathology of androgen deprivation therapy in prostate carcinoma. A comparative study of 173 patients

1995 • 105 citations

Atypical Basal Cell Hyperplasia of the Prostate

1993 • 103 citations

Significance of tumor angiogenesis inclinically localized prostate carcinoma treated with external beam radiotherapy

1994 • 101 citations

Salvage Surgery Plus Androgen Deprivation for Radioresistant Prostatic Adenocarcinoma

1992 • 100 citations

Finasteride

1993 • 99 citations

Endocrine profiles during administration of the new non‐steroidal anti‐androgen Casodex in prostate cancer

1994 • 99 citations

Workgroup 5: Assessment of prostate carcinoma in core needle biopsy--Definition of minimal criteria for the diagnosis of cancer in biopsy material

1996 • 99 citations

Does long-term finasteride therapy affect the histologic features of benign prostatic tissue and prostate cancer on needle biopsy?

1999 • 98 citations

Combined histologic grading of prostatic carcinoma

1982 • 95 citations

Combination therapy for prostate cancer. Endocrine and biologic basis of its choice as new standard first-line therapy

1993 • 94 citations

Effect of the Number of Core Biopsies of the Prostate on Predicting Gleason Score of Prostate Cancer

1996 • 91 citations

Biopsy after External Beam Radiation Therapy for Adenocarcinoma of the Prostate: Correlation with Original Histological Grade and Current Prostate Specific Antigen Levels

1991 • 88 citations

Minimal or No Cancer in Radical Prostatectomy Specimens

1995 • 87 citations

The cell cycle inhibitors p21WAF1 and p27KIP1 are associated with survival in patients treated by salvage prostatectomy after radiation therapy.

2000 • 87 citations

The Importance of Local Control in the Treatment of Prostatic Cancer

1992 • 85 citations

Histologic changes in prostate carcinomas treated with leuprolide (luteinizing hormone–-releasing hormone effect). Distinction from poor tumor differentiation

1994 • 85 citations

Keratin immunoreactivity as an aid to the diagnosis of persistent adenocarcinoma in irradiated human prostates

1989 • 84 citations

Postatrophic Hyperplasia of the Prostate

1995 • 83 citations

Dedifferentiation of locally recurrent prostate cancer after radiation therapy. Evidence for tumor progression

1993 • 83 citations

Diagnosis of Prostate Cancer in Needle Biopsies After Radiation Therapy

1999 • 82 citations

Evidence for atrophy and apoptosis in the ventral prostate of rats given the 5 alpha-reductase inhibitor finasteride.

1995 • 82 citations

Androgen receptor mutations

1995 • 81 citations

Predictors of survival for prostate carcinoma patients treated with salvage radical prostatectomy after radiation therapy

1998 • 71 citations

p53 Immunohistochemical and Genetic Alterations are Associated at High Incidence with Post-Irradiated Locally Persistent Prostate Carcinoma

1996 • 67 citations

Finasteride dose-dependently reduces the proliferation rate of the LnCap human prostatic cancer cell line in vitro

1995 • 61 citations

Response of rat and human prostatic cancers to the novel 5α‐reductase inhibitor, SK&F 105657

1992 • 61 citations

Evaluating prostate needle biopsy: therapeutic and prognostic importance

1997 • 60 citations

Androgen Receptor Expression in Prostatic Dysplasia (Prostatic lntraepithelial Neoplasia) in the Human Prostate: An Immunohistochemical and In Situ Hybridization Study

1996 • 58 citations

Urologic Surgical Pathology

1998 • 56 citations

Elevated Estrogen Receptor Expression in Human Prostatic Stromal Cells by Androgen Ablation Therapy

1996 • 55 citations

Leuprorelin

1991 • 55 citations

Androgen receptor alterations in prostatic carcinoma

1994 • 53 citations

Clear Cell Cribriform Hyperplasia of Prostate

1986 • 51 citations

The clinical significance of a positive post-irradiation prostatic biopsy without metastases

1992 • 51 citations

Histologic changes of irradiated prostatic carcinoma diagnosed by transrectal ultrasound

1992 • 50 citations

Histopathological Changes in Androgen-Deprived Localized Prostatic Cancer

1993 • 50 citations

Immunohistochemical Evaluation of Prostatic Carcinoma Before and After Radiotherapy

1980 • 46 citations

Prevalence and Distribution of Prostatic Intraepithelial Neoplasia in Salvage Radical Prostatectomy Specimens After Radiation Therapy

1999 • 46 citations

Current clinical studies with a new nonsteroidal antiandrogen, casodex

1994 • 45 citations

Comparison of the effects of new specific azasteroid inhibitors of steroid 5α‐reductase on canine hyperplastic prostate: Suppression of prostatic DHT correlated with prostate regression

1995 • 44 citations

Histological Characteristics of Prostatic Biopsies after ¹²⁵ Iodine Implantation

1980 • 44 citations

Chemoprevention of prostate cancer.

1995 • 43 citations

Apoptotic Bodies in Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma Following Total Androgen Ablation

1995 • 41 citations

Treatment of benign prostatic hyperplasia with 5-alpha-reductase inhibitor: morphological changes in patients who fail to respond.

1996 • 41 citations

Chemoprevention of prostate cancer

1994 • 40 citations

Antiandrogenic agents as monotherapy in advanced prostatic carcinoma

1993 • 39 citations

External beam irradiation of prostate cancer. Conformal treatment techniques and outcomes for the 1990

1995 • 38 citations

Predictors of survival after a positive post-irradiation prostate biopsy

1994 • 37 citations

Histologic effects of radiation therapy and total androgen blockade on prostate cancer

1995 • 37 citations

Chemoprevention of Rat Prostate Carcinogenesis by Use of Finasteride or Casodex

1995 • 35 citations

Analysis of independent variables affecting survival after recurrence of prostate cancer

1989 • 31 citations

The Histology of Radiation Therapy Effect on Prostate Adenocarcinoma as Assessed by Needle Biopsy After Brachytherapy Boost: Correlation With Biochemical Failure

1998 • 29 citations

Evidence for atrophy and apoptosis in the ventral prostate of rats given the 5 alpha-reductase inhibitor finasteride

1995 • 28 citations

Androgens regulate the expression of proliferating cell nuclear antigen posttranscriptionally in the human prostate cancer cell line, LNCaP.

1996 • 28 citations

High Grade Prostatic Intraepithelial Neoplasia in Prostates Removed Following Irradiation Failure in the Treatment of Prostatic Adenocarcinoma

1995 • 28 citations

Effect of combination treatment with zanoterone (WIN 49596), a steroidal androgen receptor antagonist, and finasteride (MK-906), a steroidal 5 alpha-reductase inhibitor, on the prostate and testes of beagle dogs.

1993 • 27 citations

Androgen-Deprived Prostate Adenocarcinoma: Evaluation of Treatment-Related Changes versus No Distinctive Treatment Effect with a Bayesian Belief Network

1996 • 25 citations

Prognostic significance of post-irradiation prostate biopsies.

1993 • 25 citations

Treatment of Advanced Prostate Cancer with the Combination of Finasteride plus Flutamide: Early Results

1993 • 24 citations

Histological and immunohistochemical findings of prostatic carcinoma after external or interstitial radiotherapy

1991 • 23 citations

Clinical Experience of the Detection of Prostate Cancer in Patients with Benign Prostatic Hyperplasia Treated with Finasteride

1994 • 22 citations

Minimal criteria for the diagnosis of prostate cancer on needle biopsy

1997 • 20 citations

Target populations and strategies for chemoprevention trials of prostate cancer.

1994 • 18 citations

Prostate Adenocarcinoma After Androgen Deprivation Therapy

1996 • 17 citations

Antiandrogens alone or in combination for treatment of prostate cancer: The European experience

1989 • 17 citations

Effect of combination treatment with zanoterone (WIN 49596), a steroidal androgen receptor antagonist, and finasteride (MK-906), a steroidal 5 alpha-reductase inhibitor, on the prostate and testes of beagle dogs

1993 • 15 citations

Management of radiation failure for localized prostate cancer

1998 • 14 citations

The role of pathologic variables and hormonal treatment after radical prostatectomy for stage D1 disease.

1991 • 13 citations

NM23 Gene Expression in Human Prostatic Carcinomas and Benign Prostatic Hyperplasias: Altered Expression in Combined Androgen Blockaded Carcinomas

1996 • 13 citations

Effect of 5‐α‐reductase inhibition and dexamethasone administration on the growth characteristics and intratumor androgen levels of the human prostate cancer cell line PC‐3

1994 • 10 citations

Stability of the Glycoprotein A-80 in Prostatic Carcinoma Subsequent to Androgen Deprivation Therapy

1997 • 8 citations

Clinical development plan: Proscar.

1994 • 4 citations

Total androgenic blockade: a review.

1995 • 2 citations

Deleted Work

1955 • 0 citations