Androgen receptor alterations in prostatic carcinoma

A mutation in the ligand binding domain of the androgen receptor of human INCaP cells affects steroid binding characteristics and response to anti-androgens

1990 • 948 citations

The LNCaP cell line--a new model for studies on human prostatic carcinoma.

1980 • 531 citations

Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors.

1988 • 530 citations

Domains of the Human Androgen Receptor Involved in Steroid Binding, Transcriptional Activation, and Subcellular Localization

1991 • 513 citations

The Promoter of the Prostate-Specific Antigen Gene Contains a Functional Androgen Responsive Element

1991 • 452 citations

Androgen receptor gene mutations in human prostate cancer.

1992 • 421 citations

Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone.

1993 • 421 citations

Triplet repeat mutations in human disease

1992 • 417 citations

Flutamide withdrawal syndrome: its impact on clinical trials in hormone-refractory prostate cancer.

1993 • 417 citations

Androgen receptors in endocrine‐therapy‐resistant human prostate cancer

1991 • 390 citations

The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor

1992 • 381 citations

Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers.

1994 • 364 citations

Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression

1991 • 303 citations

Anti-androgens and the mutated androgen receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein interaction, and transcription activation

1992 • 284 citations

Autologous Down-Regulation of Androgen Receptor Messenger Ribonucleic Acid

1990 • 272 citations

Hormonal regulation of prostate-specific antigen messenger RNA in human prostatic adenocarcinoma cell line LNCaP.

1991 • 266 citations

Growth Regulation of Estrogen Receptor-Negative Breast Cancer Cells Transfected With Complementary DNAs for Estrogen Receptor

1992 • 263 citations

Immunohistochemical study of androgen receptors in metastatic prostate cancer. Comparison of receptor content and response to hormonal therapy

1991 • 242 citations

Androgen Receptor Assay with [³H]Methyltrienolone (R1881) in the Presence of Progesterone Receptors*

1979 • 223 citations

Androgen Resistance — The Clinical and Molecular Spectrum

1992 • 221 citations

Androgen receptor gene expression in human prostate carcinoma cell lines.

1990 • 220 citations

Aberrant response in vitro of hormone‐responsive prostate cancer cells to antiandrogens

1989 • 208 citations

Assay of androgen binding sites by exchange with methyltrienolone (R 1881)

1976 • 191 citations

Hormonal regulation of prostate‐specific antigen (PSA) glycoprotein in the human prostatic adenocarcinoma cell line, LNCaP

1992 • 179 citations

Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone

1993 • 178 citations

Antipeptide Antibodies to Two Distinct Regions of the Androgen Receptor Localize the Receptor Protein to the Nuclei of Target Cells in the Rat and Human Prostate*

1990 • 173 citations

Microsatellite Mutation (Cag24→18) in the Androgen Receptor Gene in Human Prostate Cancer

1994 • 166 citations

Androgens up-regulate the human prostate-specific antigen messenger ribonucleic acid (mRNA), but down-regulate the prostatic acid phosphatase mRNA in the LNCaP cell line.

1992 • 166 citations

Unusual specificity of the androgen receptor in the human prostate tumor cell line LNCaP: High affinity for progestagenic and estrogenic steroids

1990 • 165 citations

Correlation of Prostatic Nuclear Androgen Receptor Content with Duration of Response and Survival Following Hormonal Therapy in Advanced Prostatic Cancer

1982 • 160 citations

Androgen-induced inhibition of cell proliferation in an androgen-insensitive prostate cancer cell line (PC-3) transfected with a human androgen receptor complementary DNA.

1993 • 148 citations

Regulation of growth and epidermal growth factor receptor levels of LNCaP prostate tumor cells by different steroids

1988 • 139 citations

Androgen‐dependent growth regulation of and release of specific protein(s) by the androgen receptor containing human prostate tumor cell line LNCaP

1986 • 137 citations

Hormone-induced dissociation of the androgen receptor-heat-shock protein complex: use of a new monoclonal antibody to distinguish transformed from nontransformed receptors

1992 • 136 citations

Chromosomal abnormalities and related events in prostate cancer

1992 • 120 citations

Image analysis of androgen receptor immunostaining in metastatic prostate cancer heterogeneity as a predictor of response to hormonal therapy

1993 • 117 citations

DNA sequence of the androgen receptor in prostatic tumor cell lines and tissue specimens assessed by means of the polymerase chain reaction

1993 • 117 citations

Androgen receptor heterogeneity in human prostatic carcinomas visualized by immunohistochemistry

1990 • 104 citations

Human prostate cancer model: Roles of growth factors and extracellular matrices

1992 • 95 citations

Androgens up-regulate the human prostate-specific antigen messenger ribonucleic acid (mRNA), but down-regulate the prostatic acid phosphatase mRNA in the LNCaP cell line

1992 • 87 citations

Point mutation of estrogen receptor (ER) in the ligand-binding domain changes the pharmacology of antiestrogens in ER-negative breast cancer cells stably expressing complementary DNAs for ER.

1992 • 75 citations

The androgen receptor: Functional structure and expression in transplanted human prostate tumors and prostate tumor cell lines

1990 • 70 citations

Expression and localization of androgen receptor in the R-3327 Dunning rat prostatic adenocarcinoma.

1990 • 60 citations

Stimulatory effects of antiandrogens on LNCaP human prostate tumor cell growth, EGF-receptor level and acid phosphatase secretion

1990 • 59 citations

Steroid receptors in metastatic carcinoma of the human prostate

1979 • 57 citations

The use of radioactive 7α, 17α‐dimethyl‐19‐nortestosterone (mibolerone) in the assay of androgen receptors

1984 • 48 citations

Steroids inversely affect the biosynthesis and secretion of human prostatic acid phosphatase and prostate-specific antigen in the LNCaP cell line

1992 • 42 citations

Domain functions of the androgen receptor

1992 • 40 citations

Characterization of steroid receptors in human prostate using mibolerone

1986 • 33 citations

Point mutation of estrogen receptor (ER) in the ligand-binding domain changes the pharmacology of antiestrogens in ER-negative breast cancer cells stably expressing complementary DNAs for ER

1992 • 32 citations

A critical evaluation of the use of androgen receptor assays to predict the androgen responsiveness of prostatic cancer.

1987 • 30 citations

Relationship between androgen receptor binding activity in human prostate cancer and clinical response to endocrine therapy

1987 • 27 citations

Nuclear androgen receptor content in biopsy specimens from histologically normal, hyperplastic, and cancerous human prostatic tissue

1985 • 26 citations

Androgen receptors in biopsy specimens of prostate adenocarcinoma. Heterogeneity of distribution and relation to prognostic significance of receptor measurements for survival of advanced cancer patients

1987 • 25 citations

Prediction of time to progression after orchiectomy by the nuclear androgen receptor content from multiple biopsy specimens in patients with advanced prostate cancer

1988 • 19 citations

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