Finasteride

The Development of Human Benign Prostatic Hyperplasia with Age

1984 • 2,391 citations

A Controlled Trial of Leuprolide with and without Flutamide in Prostatic Carcinoma

1989 • 1,494 citations

The Effect of Finasteride in Men with Benign Prostatic Hyperplasia

1992 • 1,111 citations

Deletion of steroid 5α-reductase 2 gene in male pseudohermaphroditism

1991 • 641 citations

Etiology and disease process of benign prostatic hyperplasia

1989 • 557 citations

Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases.

1990 • 491 citations

Male hormone stimulation is prerequisite and an incitant in common baldness

1942 • 464 citations

Testosterone at High Concentrations Interacts with the Human Androgen Receptor Similarly to Dihydrotestosterone*

1990 • 428 citations

Molecular genetics of steroid 5 alpha-reductase 2 deficiency.

1992 • 414 citations

Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase.

1992 • 395 citations

The pathogenesis of benign prostatic hyperplasia

1980 • 353 citations

The Effect of Nafarelin Acetate, a Luteinizing-Hormone–Releasing Hormone Agonist, on Benign Prostatic Hyperplasia

1987 • 334 citations

1 Adrenal and gonadal androgen secretion in normal females

1986 • 325 citations

The Natural History of Untreated “Prostatism”

1981 • 288 citations

Prostate Specific Antigen in the Diagnosis and Treatment of Adenocarcinoma of the Prostate. I. Untreated Patients

1989 • 269 citations

Azasteroids: structure-activity relationships for inhibition of 5.alpha.-reductase and of androgen receptor binding

1986 • 252 citations

Expression Cloning and Regulation of Steroid 5α-Reductase, an Enzyme Essential for Male Sexual Differentiation

1989 • 247 citations

The clinical development of a 5α-reductase inhibitor, finasteride

1990 • 221 citations

The Effect of Castration on Benign Hypertrophy of the Prostate in Man

1940 • 173 citations

Finasteride (MK‐906) in the treatment of benign prostatic hyperplasia

1993 • 170 citations

The Clinical Effects of a 5α-Reductase Inhibitor, Finasteride, on Benign Prostatic Hyperplasia

1992 • 168 citations

Characterization of the Cytosol Androgen Receptor of the Human Prostate*

1983 • 167 citations

Effects of Finasteride (MK-906), a 5α-Reductase Inhibitor, on Circulating Androgens in Male Volunteers*

1990 • 163 citations

A cluster of male pseudohermaphrodites with 5α‐reductase deficiency in Papua New Guinea

1991 • 157 citations

Characterization and chromosomal mapping of a human steroid 5α-reductase gene and pseudogene and mapping of the mouse homologue

1991 • 151 citations

Urodynamics in benign prostatic hyperplasia: A survey

1989 • 143 citations

Effect of Finasteride, a 5α-Reductase Inhibitor on Prostate Tissue Androgens and Prostate-Specific Antigen*

1990 • 136 citations

The effect of finasteride on prostate‐specific antigen in men with benign prostatic hyperplasia

1993 • 133 citations

Identification and selective inhibition of an isozyme of steroid 5 alpha-reductase in human scalp.

1992 • 131 citations

External genitalia abnormalities in male rats exposed in utero to finasteride, a 5α‐reductase inhibitor

1990 • 127 citations

Multicenter, Randomized, Double-Blind, Placebo Controlled Study to Investigate the Effect of Finasteride (MK-906) on Stage D Prostate Cancer

1992 • 124 citations

Testosterone Administration Inhibits Gonadotropin Secretion by an Effect Directly on the Human Pituitary*

1989 • 119 citations

Finasteride, an inhibitor of 5 alpha-reductase, suppresses prostatic dihydrotestosterone in men with benign prostatic hyperplasia

1992 • 117 citations

The Molecular Basis of Steroid 5α-Reductase Deficiency in a Large Dominican Kindred

1992 • 117 citations

Characterization of 5α-Reductase in Cultured Human Dermal Papilla Cells from Beard and Occipital Scalp Hair

1991 • 117 citations

Hormonal effects of an orally active 4‐azasteroid inhibitor of 5α‐reductase in humans

1989 • 105 citations

Inhibitors of steroid 5α-reductase in benign prostatic hyperplasia, male pattern baldness and acne

1989 • 104 citations

The androgen control of sebum production. Studies of subjects with dihydrotestosterone deficiency and complete androgen insensitivity

1993 • 100 citations

Steroid 5alpha-reductase in cultured human fibroblasts. Biochemical and genetic evidence for two distinct enzyme activities.

1976 • 99 citations

Comparison of the effects of the 5 alpha-reductase inhibitor finasteride and the antiandrogen flutamide on prostate and genital differentiation: dose-response studies

1992 • 90 citations

Three-Month Treatment With a Long-Acting Gonadotropin-Releasing Hormone Agonist of Patients With Benign Prostatic Hyperplasia: Effects on Tissue Androgen Concentration, 5α-Reductase Activity and Androgen Receptor Content*

1989 • 85 citations

Effect of MK‐906, a Specific 5α‐reductase Inhibitor, on Serum Androgens and Androgen Conjugates in Normal Men

1989 • 82 citations

Prostate visualization studies in males homozygous and heterozygous for 5 alpha-reductase deficiency

1992 • 66 citations

Urodynamic Effects of Finasteride in the Treatment of Bladder Outlet Obstruction due to Benign Prostatic Hyperplasia

1993 • 65 citations

Androgen Metabolism in Men Receiving Finasteride before Prostatectomy

1993 • 62 citations

Pharmacokinetics and biochemical efficacy after single and multiple oral administration of N-(2-methyl-2-propyl)-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide, a new type of specific competitive inhibitor of testosterone 5α-reductase, in volunteers

1991 • 59 citations

Characterization of the Testicular Abnormality in 5a-Reductase Deficiency*

1986 • 58 citations

Differential Effect of 5α-Reductase Inhibition and Castration on Androgen-Regulated Gene Expression in Rat Prostate

1991 • 57 citations

Hair growth effects of oral administration of finasteride, a steroid 5 alpha-reductase inhibitor, alone and in combination with topical minoxidil in the balding stumptail macaque

1992 • 57 citations

C₁₉and C₂₁5β/5αMetabolite Ratios in Subjects Treated with the 5α-Reductase Inhibitor Finasteride: Comparison of Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency*

1990 • 57 citations

External genitalia of the rat: Normal development and the histogenesis of 5α‐reductase inhibitor‐induced abnormalities

1990 • 55 citations

Effect of Long-Acting Gonadotropin-Releasing Hormone Analog (Leuprolide) Therapy on Prostatic Size and Symptoms in 15 Men with Benign Prostatic Hypertrophy

1989 • 53 citations

Prolonged treatment with finasteride (a 5α‐reductase inhibitor) does not affect bone density and metabolism

1992 • 52 citations

Role of 5α-Reductase Inhibitors in the Treatment of Advanced Prostatic Carcinoma

1991 • 39 citations

Pathogenesis and medical treatment of benign prostatic hyperplasia

1989 • 37 citations

Hormonal effects, tolerability, and preliminary kinetics in men of MK-906, a 5α-reductase inhibitor

1991 • 29 citations

The dissociation of testosterone- and 5α-dihydrotestosterone-receptor complexes formed within cultured human genital skin fibroblasts

1983 • 28 citations

The costs of prostatectomy for benign prostatic hyperplasia

1993 • 28 citations

Effect of finasteride, a 5 alpha-reductase inhibitor, on serum gonadotropins in normal men

1992 • 26 citations

Studies on the mechanism of steroid 5α-reductase inhibition by 3-carboxy A-ring aryl steroids

1990 • 13 citations

From the Food and Drug Administration

1992 • 6 citations