Transient IL-7/IL-7R Signaling Provides a Mechanism for Feedback Inhibition of Immunoglobulin Heavy Chain Gene Rearrangements

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

B Cell Development Pathways

2001 • 1,185 citations

The RAG Proteins and V(D)J Recombination: Complexes, Ends, and Transposition

2000 • 616 citations

Targeted disruption of µ chain membrane exon causes loss of heavy-chain allelic exclusion

1992 • 376 citations

Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci

2001 • 362 citations

An active tissue-specific enhancer and bound transcription factors existing in a precisely positioned nucleosomal array

1993 • 336 citations

Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor

1998 • 331 citations

Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-κB

2001 • 316 citations

Cell Type–Specific Chromatin Structure Determines the Targeting of V(D)J Recombinase Activity In Vitro

1996 • 305 citations

Allelic Exclusion in Transgenic Mice That Express the Membrane form of Immunoglobulin μ

1987 • 293 citations

Changes in the VH Gene Repertoire of Developing Precursor B Lymphocytes in Mouse Bone Marrow Mediated by the Pre-B Cell Receptor

1997 • 253 citations

A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q

1994 • 243 citations

Effects of different DNA polymerases in ligation-mediated PCR: enhanced genomic sequencing and in vivo footprinting.

1992 • 232 citations

Analysis of the B-cell progenitor compartment at the level of single cells

1994 • 232 citations

Reduced Isotype Switching in Splenic B Cells from Mice Deficient in Mismatch Repair Enzymes

1999 • 218 citations

Induction of Self-Rolerance in T Cells But Not B Cells of Transgenic Mice Expressing Little Self Antigen

1991 • 211 citations

Stepwise activation of the immunoglobulin micro heavy chain gene locus

2001 • 210 citations

Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice.

1990 • 203 citations

Recent Advances in Understanding V(D)J Recombination

1997 • 196 citations

Factors and Forces Controlling V(D)J Recombination

2001 • 187 citations

Rapid and Selective Remodeling of a Positioned Nucleosome during the Induction of IL-12 p40 Transcription

1999 • 184 citations

Pre-B Cell Receptor Signaling Mediates Selective Response to IL-7 at the Pro-B to Pre-B Cell Transition via an ERK/MAP Kinase-Dependent Pathway

2001 • 172 citations

A transgenic immunoglobulin Mu gene prevents rearrangement of endogenous genes

1985 • 169 citations

Pax5is required for recombination of transcribed, acetylated, 5′ IgH V gene segments

2003 • 168 citations

Cytoplasmic Sequestration of Rel Proteins by IκBα Requires CRM1-Dependent Nuclear Export

2000 • 151 citations

Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains.

1988 • 138 citations

Modulation of the IL-7 Dose-Response Threshold During Pro-B Cell Differentiation Is Dependent on Pre-B Cell Receptor Expression

1998 • 138 citations

VpreB1/VpreB2/λ5 Triple-Deficient Mice Show Impaired B Cell Development but Functional Allelic Exclusion of the IgH Locus

2002 • 136 citations

An active v-abl protein tyrosine kinase blocks immunoglobulin light-chain gene rearrangement.

1994 • 134 citations

Surface expression of the beta T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells.

1991 • 121 citations

Cyclin A/CDK2 Regulates V(D)J Recombination by Coordinating RAG-2 Accumulation and DNA Repair

1999 • 120 citations

Changes in Locus-specific V(D)J Recombinase Activity Induced by Immunoglobulin Gene Products during B Cell Development

1997 • 116 citations

Chromatin Remodeling at the Ig Loci Prior to V(D)J Recombination

2001 • 104 citations

Allelic exclusion at the TCRβ locus

2002 • 92 citations

A Change in the Structure of Vβ Chromatin Associated with TCR β Allelic Exclusion

2002 • 82 citations

Frequency of VH81x usage during B cell development: initial decline in usage is independent of Ig heavy chain cell surface expression.

1996 • 80 citations

Expression of Recombination Activating Genes in Germinal Center B Cells: Involvement of Interleukin 7 (IL-7) and the IL-7 Receptor

1998 • 75 citations

Rearrangement of IgH genes in normal thymocyte development.

1988 • 71 citations

Murine Pro-B Cells Require IL-7 and Its Receptor Complex to Up-Regulate IL-7Rα, Terminal Deoxynucleotidyltransferase, and cμ Expression

2000 • 69 citations

Linkage analyses of murine immunoglobulin heavy chain and serum prealbumin genes establish their location on chromosome 12 proximal to the T (5;12) 31H breakpoint in band 12F1.

1980 • 62 citations

The roles of preB and B cell receptors in the stepwise allelic exclusion of mouse IgH and L chain gene loci

1999 • 60 citations

Frequency and Characterization of Phenotypic Ig Heavy Chain Allelically Included IgM-Expressing B Cells in Mice

2000 • 57 citations

Functional GATA-3 binding sites within murine CD8 alpha upstream regulatory sequences.

1993 • 56 citations

Chromosomal position of rearranging gene segments influences allelic exclusion in transgenic mice.

1992 • 53 citations

Deletional mapping of fifteen mouse VH gene families reveals a common organization for three Igh haplotypes.

1996 • 51 citations

VH gene family repertoire of resting B cells. Preferential use of D-proximal families early in development may be due to distinct B cell subsets.

1989 • 51 citations

Accessibility control of variable region gene assembly during T‐cell development

1998 • 48 citations

A Three-Megabase Yeast Artificial Chromosome Contig Spanning the C57BL Mouse Igh Locus

2002 • 44 citations

Allelic exclusion in B and T lymphopoiesis

1999 • 41 citations

IL-7 Reconstitutes Multiple Aspects of v-Abl-Mediated Signaling

1998 • 35 citations

The variable, CH1, CH2 and CH3 domains of Ig heavy chain are dispensable for pre‐BCR function in transgenic mice

2002 • 33 citations

Accessibility changes across the mouse Igh-V locus during B cell development

1998 • 32 citations

Inhibition of Interleukin 7 Receptor Signaling by Antigen Receptor Assembly

2000 • 28 citations

Extended Duration of DH–JH Rearrangement in Immunoglobulin Heavy Chain Transgenic Mice: Implications for Regulation of Allelic Exclusion

1999 • 27 citations

Contribution of light chain rearrangement in peripheral B cells to the generation of high-affinity antibodies

2002 • 27 citations

Endogenous immunoglobulin expression in mu transgenic mice

1991 • 25 citations

A detailed linkage map of subtelomeric murine Chromosome 12 region including the situs inversus mutation locus IV

1992 • 10 citations

The locus for the serum prealbumin is proximal to the heavy chain locus on mouse chromosome 12q+.

1986 • 10 citations