Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination

Genome maintenance mechanisms for preventing cancer

2001 • 3,819 citations

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

2000 • 3,323 citations

Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)

2000 • 1,604 citations

DNA MISMATCH REPAIR

2005 • 1,296 citations

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

2002 • 879 citations

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

2003 • 723 citations

R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells

2003 • 712 citations

Immunoglobulin Isotype Switching Is Inhibited and Somatic Hypermutation Perturbed in UNG-Deficient Mice

2002 • 701 citations

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

2003 • 662 citations

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

2003 • 646 citations

Human uracil–DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

2003 • 619 citations

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

2004 • 567 citations

Uracil in DNA – occurrence, consequences and repair

2002 • 458 citations

AID Mediates Hypermutation by Deaminating Single Stranded DNA

2003 • 457 citations

Mismatch Recognition and Uracil Excision Provide Complementary Paths to Both Ig Switching and the A/T-Focused Phase of Somatic Mutation

2004 • 456 citations

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

2003 • 428 citations

Reconstitution of 5′-Directed Human Mismatch Repair in a Purified System

2005 • 362 citations

hUNG2 Is the Major Repair Enzyme for Removal of Uracil from U:A Matches, U:G Mismatches, and U in Single-stranded DNA, with hSMUG1 as a Broad Specificity Backup

2002 • 330 citations

Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination

1997 • 305 citations

The cellular response to general and programmed DNA double strand breaks

2004 • 300 citations

Human Exonuclease I Is Required for 5′ and 3′ Mismatch Repair

2002 • 250 citations

Mechanism of 5′-Directed Excision in Human Mismatch Repair

2003 • 247 citations

Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1–mutant mice

2004 • 243 citations

DNA Structural Elements Required for ERCC1-XPF Endonuclease Activity

1998 • 225 citations

Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation

1999 • 219 citations

Reduced Isotype Switching in Splenic B Cells from Mice Deficient in Mismatch Repair Enzymes

1999 • 218 citations

The influence of transcriptional orientation on endogenous switch region function

2003 • 208 citations

DNA Substrate Length and Surrounding Sequence Affect the Activation-induced Deaminase Activity at Cytidine

2004 • 192 citations

MSH2–MSH6 stimulates DNA polymerase η, suggesting a role for A:T mutations in antibody genes

2005 • 190 citations

Inducible DNA breaks in Ig S regions are dependent on AID and UNG

2005 • 174 citations

A Role for Msh6 But Not Msh3 in Somatic Hypermutation and Class Switch Recombination

2004 • 160 citations

Biochemical Analysis of Hypermutational Targeting by Wild Type and Mutant Activation-induced Cytidine Deaminase

2004 • 148 citations

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells

2005 • 143 citations

Role for Mismatch Repair Proteins Msh2, Mlh1, and Pms2 in Immunoglobulin Class Switching Shown by Sequence Analysis of Recombination Junctions

2002 • 134 citations

Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination

2001 • 132 citations

Requirement of Mismatch Repair Genes MSH2 and MSH3 in the RAD1-RAD10 Pathway of Mitotic Recombination in Saccharomyces cerevisiae

1996 • 131 citations

MutSα Binds to and Promotes Synapsis of Transcriptionally Activated Immunoglobulin Switch Regions

2005 • 120 citations

Msh2 ATPase Activity Is Essential for Somatic Hypermutation at A-T Basepairs and for Efficient Class Switch Recombination

2003 • 98 citations

Examination of Msh6- and Msh3-deficient Mice in Class Switching Reveals Overlapping and Distinct Roles of MutS Homologues in Antibody Diversification

2004 • 96 citations

Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S in Ig class switch recombination

2004 • 95 citations

The μ Switch Region Tandem Repeats Are Important, but Not Required, for Antibody Class Switch Recombination

2001 • 91 citations

Efficiency of Repair of an Abasic Site within DNA Clustered Damage Sites by Mammalian Cell Nuclear Extracts

2004 • 91 citations

Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch.

1989 • 87 citations

The Block in Immunoglobulin Class Switch Recombination Caused by Activation-Induced Cytidine Deaminase Deficiency Occurs Prior to the Generation of DNA Double Strand Breaks in Switch μ Region

2003 • 85 citations

Mutations occur in the Ig S region but rarely in S regions prior to class switch recombination

2003 • 71 citations

Immunoglobulin class-switch recombination in mice devoid of any Sμ tandem repeat

2004 • 70 citations

Mlh1 Can Function in Antibody Class Switch Recombination Independently of Msh2

2003 • 58 citations

The Sμ Tandem Repeat Region Is Critical for Ig Isotype Switching in the Absence of Msh2

2003 • 58 citations

Cutting Edge: The G-U Mismatch Glycosylase Methyl-CpG Binding Domain 4 Is Dispensable for Somatic Hypermutation and Class Switch Recombination

2003 • 44 citations

Deletion of the Nucleotide Excision Repair Gene Ercc1 Reduces Immunoglobulin Class Switching and Alters Mutations Near Switch Recombination Junctions

2004 • 38 citations

Shifts in targeting of class switch recombination sites in mice that lack μ switch region tandem repeats or Msh2

2005 • 33 citations

DNA Repair of Clustered Uracils in HeLa Cells

2004 • 28 citations

Oligonucleotides with Bistranded Abasic Sites Interfere with Substrate Binding and Catalysis by Human Apurinic/Apyrimidinic Endonuclease

2001 • 25 citations