Localization of the Vinblastine-binding Site on β-Tubulin

Taxol binds to polymerized tubulin in vitro

1981 • 618 citations

Taxol: an antimitotic agent with a new mechanism of action

1984 • 483 citations

MICROTUBULAR CRYSTALS IN MAMMALIAN CELLS

1969 • 417 citations

Taxol binds to cellular microtubules.

1982 • 408 citations

Properties of colchicine binding protein from chick embryo brain. Interactions with vinca alkaloids and podophyllotoxin

1970 • 391 citations

3'-(p-azidobenzamido)taxol photolabels the N-terminal 31 amino acids of beta-tubulin.

1994 • 244 citations

Kinetic stabilization of microtubule dynamic instability in vitro by vinblastine

1993 • 240 citations

Podophyllotoxin as a probe for the colchicine binding site of tubulin.

1977 • 231 citations

Characterization of the Taxol Binding Site on the Microtubule

1995 • 229 citations

Separation of active tubulin and microtubule-associated proteins by ultracentrifugation and isolation of a component causing the formation of microtubule bundles

1984 • 224 citations

Promotion of Fluorescence upon Binding of Colchicine to Tubulin

1974 • 218 citations

Tubulin sulfhydryl groups as probes and targets for antimitotic and antimicrotubule agents

1991 • 205 citations

Localization of the colchicine-binding site of tubulin.

1993 • 156 citations

Interactions of the catharanthus (Vinca) alkaloids with tubulin and microtubules

1991 • 145 citations

Effect of antimitotic drugs on tubulin GTPase activity and self-assembly.

1979 • 142 citations

Binding of maytansine to rat brain tubulin

1976 • 123 citations

Interaction of vinblastine with steady-state microtubules in vitro

1982 • 112 citations

Molecular mechanism of colchicine action: Induced local unfolding of .beta.-tubulin

1993 • 100 citations

Maytansine binding to the vinblastine sites of tubulin

1977 • 99 citations

Tubulin aggregation and disaggregation: mediation by two distinct vinblastine-binding sites.

1976 • 92 citations

Microtubule-Macrotubule Transitions: Intermediates after Exposure to the Mitotic Inhibitor Vinblastine

1974 • 78 citations

Taxol effect on tubulin polymerization and associated guanosine 5'-triphosphate hydrolysis

1983 • 76 citations

Exchangeable GTP binding site of beta-tubulin. Identification of cysteine 12 as the major site of cross-linking by direct photoaffinity labeling.

1993 • 76 citations

Effects of inhibitors of tubulin polymerization on GTP hydrolysis.

1981 • 75 citations

Properties of tubulin in unfertilized sea urchin eggs. Quantitation and characterization by the colchicine-binding reaction.

1976 • 67 citations

Direct photoaffinity labeling of tubulin with colchicine.

1991 • 59 citations

The interaction of 1-anilino-8-naphthalene sulfonate with tubulin: A site independent of the colchicine-binding site

1975 • 57 citations

Vinca Site Agents Induce Structural Changes in Tubulin Different from and Antagonistic to Changes Induced by Colchicine Site Agents

1995 • 56 citations

Fluorescence properties of 2′ (or 3′)-O-(2,4,6-trinitrophenyl) adenosine 5′-triphosphate and its use in the study of binding to heavy meromyosin ATPase

1976 • 51 citations

Photoaffinity labeling of tubulin subunits with a photoactive analog of vinblastine

1987 • 48 citations

A REEXAMINATION OF THE REACTION BETWEEN COLCHICINE AND TUBULIN*

1975 • 44 citations

Spectroscopic studies of the interactions of coenzymes and coenzyme fragments with pig heart oxidized triphosphopyridine nucleotide specific isocitrate dehydrogenase

1985 • 40 citations

Interaction of a fluorescent paclitaxel analog with tubulin

1995 • 38 citations

Isolation of microtubule protein from mammalian brain frozen for extended periods of time

1991 • 37 citations

Immunological detection of microtubule poison-induced conformational changes in tubulin.

1983 • 21 citations

Identification of the fragment photoaffinity-labeled with azidodansyl-rhizoxin as Met-363-Lys-379 on β-tubulin

1993 • 19 citations

Interaction of a new photosensitive derivative of vinblastine, NAPAVIN, with tubulin and microtubules in vitro

1990 • 11 citations

Aging of tubulin at neutral pH: The destabilizing effect of vinca alkaloids

1992 • 11 citations

Vinblastine-enhanced colchicine binding to tubulin in mouse fibroblasts

1977 • 6 citations

Interaction of Ant-ATP with Tubulin: Evidence for ATP Competition for the GTP E-Site on Tubulin

1993 • 3 citations