Glutamate metabotropic receptors as targets for drug therapy in epilepsy

PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

1997 • 3,070 citations

Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy

1985 • 1,730 citations

Basic Neurochemistry: Molecular, Cellular, and Medical Aspects

1989 • 1,360 citations

Sequence and expression of a metabotropic glutamate receptor

1991 • 1,200 citations

Differential Presynaptic Localization of Metabotropic Glutamate Receptor Subtypes in the Rat Hippocampus

1997 • 1,105 citations

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

1999 • 1,055 citations

Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors

2000 • 880 citations

A family of metabotropic glutamate receptors

1992 • 873 citations

Basic Neurochemistry: Molecular, Cellular, and Medical Aspects

1989 • 837 citations

Metabotropic glutamate receptors: electrophysiological properties and role in plasticity

1999 • 770 citations

A new type of glutamate receptor linked to inositol phospholipid metabolism

1987 • 743 citations

Glutamate stimulates inositol phosphate formation in striatal neurones

1985 • 734 citations

Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system.

2001 • 678 citations

Cloning, Expression, and Gene Structure of a G Protein-Coupled Glutamate Receptor from Rat Brain

1991 • 524 citations

Ligands for Glutamate Receptors: Design and Therapeutic Prospects

2000 • 520 citations

Metabotropic Glutamate Receptors 1 and 5 Differentially Regulate CA1 Pyramidal Cell Function

2001 • 433 citations

Glutamate receptors: brain function and signal transduction

1998 • 342 citations

Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites

2001 • 338 citations

(RS)-2-Chloro-5-Hydroxyphenylglycine (CHPG) Activates mGlu5, but not mGlu1, Receptors Expressed in CHO Cells and Potentiates NMDA Responses in the Hippocampus

1997 • 306 citations

The Metabotropic Glutamate Receptors: Structure, Activation Mechanism and Pharmacology

2002 • 288 citations

Upregulation of metabotropic glutamate receptor subtype mGluR3 and mGluR5 in reactive astrocytes in a rat model of mesial temporal lobe epilepsy

2000 • 285 citations

The Non-competitive Antagonists 2-Methyl-6-(phenylethynyl)pyridine and 7-Hydroxyiminocyclopropan[b]chromen-1a-carboxylic Acid Ethyl Ester Interact with Overlapping Binding Pockets in the Transmembrane Region of Group I Metabotropic Glutamate Receptors

2000 • 263 citations

Metabotropic Glutamate Receptor 1-Induced Upregulation of NMDA Receptor Current: Mediation through the Pyk2/Src-Family Kinase Pathway in Cortical Neurons

2002 • 217 citations

Cloning and Expression of Rat Metabotropic Glutamate Receptor 8 Reveals a Distinct Pharmacological Profile

1997 • 209 citations

Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7

2001 • 196 citations

Selective mGluR5 antagonists MPEP and SIB‐1893 decrease NMDA or glutamate‐mediated neuronal toxicity through actions that reflect NMDA receptor antagonism

2000 • 194 citations

Effects of levetiracetam, a novel antiepileptic drug, on convulsant activity in two genetic rat models of epilepsy

1995 • 193 citations

The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice

1991 • 188 citations

Clonazepam suppresses GABAB-mediated inhibition in thalamic relay neurons through effects in nucleus reticularis

1994 • 181 citations

SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5.

1999 • 180 citations

Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB‐1893 and MPEP

2003 • 174 citations

Glutamate receptors and transporters in genetic and acquired models of epilepsy

1999 • 166 citations

BAY36-7620: A Potent Non-Competitive mGlu1 Receptor Antagonist with Inverse Agonist Activity.

2001 • 166 citations

Distribution and roles of metabotropic glutamate receptors in the basal ganglia motor circuit: implications for treatment of Parkinson's Disease and related disorders

2000 • 163 citations

(R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo.

1999 • 161 citations

Calmodulin Dependence of Presynaptic Metabotropic Glutamate Receptor Signaling

1999 • 156 citations

New perspectives for the development of selective metabotropic glutamate receptor ligands

1999 • 150 citations

(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord

2001 • 147 citations

Anticonvulsant activity of two metabotropic glutamate Group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893)

2000 • 146 citations

Allosteric modulators of group I metabotropic glutamate receptors: novel subtype-selective ligands and therapeutic perspectives

2002 • 145 citations

Induction or protection of limbic seizures in mice by mGluR subtype selective agonists

1995 • 140 citations

9. Excitotoxicity and epileptic brain damage

1991 • 139 citations

Phosphorylation and Calmodulin Binding of the Metabotropic Glutamate Receptor Subtype 5 (mGluR5) Are Antagonistic in Vitro

1997 • 134 citations

Retracted: Neuroprotection mediated by glial group‐II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol‐3‐kinase pathways

2001 • 125 citations

Activation of Group I Metabotropic Glutamate Receptors Produces a Direct Excitation and Disinhibition of GABAergic Projection Neurons in the Substantia Nigra Pars Reticulata

2001 • 125 citations

mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors.

2001 • 115 citations

Modulation of Absence Seizures by the GABA_A Receptor: A Critical Role for Metabotropic Glutamate Receptor 4 (mGluR4)

2000 • 115 citations

Activation of Metabotropic Glutamate Receptor 1 Accelerates NMDA Receptor Trafficking

2001 • 112 citations

The Novel Metabotropic Glutamate Receptor Agonist 2 R ,4 R -APDC Potentiates Stimulation of Phosphoinositide Hydrolysis in the Rat Hippocampus by 3,5-dihydroxyphenylglycine: Evidence for a Synergistic Interaction Between Group 1 and Group 2 Receptors

1996 • 104 citations

Temporal Lobe Epilepsy Associated Up-Regulation of Metabotropic Glutamate Receptors: Correlated Changes in mGluR1 mRNA and Protein Expression in Experimental Animals and Human Patients

2000 • 101 citations

Selective Blockade of Type-1 Metabotropic Glutamate Receptors Induces Neuroprotection by Enhancing Gabaergic Transmission

2001 • 99 citations

Convulsions induced in 10-day-old rats by intraperitional injection of monosodium glutamate and related excitant amino acids

1973 • 98 citations

Epileptogenesis in vivo enhances the sensitivity of inhibitory presynaptic metabotropic glutamate receptors in basolateral amygdala neurons in vitro.

1997 • 90 citations

Coordinate regulation of metabotropic glutamate receptors

2001 • 88 citations

Changes in metabotropic glutamate receptor 1-8 gene expression in the rodent basal ganglia motor loop following lesion of the nigrostriatal tract

2002 • 84 citations

Expression of metabotropic glutamate receptor 5 is increased in astrocytes after kainate-induced epileptic seizures

2000 • 80 citations

EpileptogenesisIn VivoEnhances the Sensitivity of Inhibitory Presynaptic Metabotropic Glutamate Receptors in Basolateral Amygdala NeuronsIn Vitro

1997 • 80 citations

Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid)

1999 • 79 citations

Prolonged anticonvulsant action of glutamate metabotropic receptor agonists in inferior colliculus of genetically epilepsy-prone rats

1997 • 79 citations

Cocaine and Kindling Alter the Sensitivity of Group II and III Metabotropic Glutamate Receptors in the Central Amygdala

2000 • 77 citations

Up-regulation of the metabotropic glutamate receptor mGluR4 in hippocampal neurons with reduced seizure vulnerability

2000 • 74 citations

Anti-epileptogenic and anticonvulsant activity of l-2-amino-4-phosphonobutyrate, a presynaptic glutamate receptor agonist

1997 • 72 citations

Expression of the group II and III metabotropic glutamate receptors in the hippocampus of patients with mesial temporal lobe epilepsy.

2001 • 72 citations

Differential Roles for mGluR1 and mGluR5 in the Persistent Prolongation of Epileptiform Bursts

2002 • 72 citations

Anticonvulsive and neuroprotective actions of a potent agonist (DCG-IV) for Group II metabotropic glutamate receptors against intraventricular kainate in the rat

1997 • 72 citations

Roles of metabotropic glutamate receptors in glial function and glial-neuronal communication

1996 • 70 citations

Convulsant and anticonvulsant actions of agonists and antagonists of group III mGluRs

1996 • 69 citations

Performance deficits of mGluR8 knockout mice in learning tasks: the effects of null mutation and the background genotype

2002 • 68 citations

Altered expression of group I metabotropic glutamate receptors in the hippocampus of amygdala-kindled rats

1996 • 68 citations

Anticonvulsant and glutamate release-inhibiting properties of the highly potent metabotropic glutamate receptor agonist (2S,2′R,3′R)-2-(2′,3′-dicarboxycyclopropyl)glycine (DCG-IV)

1998 • 68 citations

Seizures and neuronal damage induced in the rat by activation of group I metabotropic glutamate receptors with their selective agonist 3,5-dihydroxyphenylglycine

1998 • 67 citations

Blockade of both epileptogenesis and glutamate release by (1S,3S)-ACPD, a presynaptic glutamate receptor agonist

1995 • 66 citations

Kindling‐induced overexpression of Homer 1A and its functional implications for epileptogenesis

2002 • 66 citations

cAMP-Dependent Protein Kinase Inhibits mGluR2 Coupling to G-Proteins by Direct Receptor Phosphorylation

2000 • 66 citations

(S)‐Carboxy‐3‐Hydroxyphenylglycine, an Antagonist of Metabotropic Glutamate Receptor (mGluR)1a and an Agonist of mGluR2, Protects Against Audiogenic Seizures in DBA/2 Mice

1994 • 59 citations

Anti-epileptic activity of group II metabotropic glutamate receptor agonists (−)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (−)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795)

2001 • 58 citations

Mechanisms of metabotropic glutamate receptor desensitization: role in the patterning of effector enzyme activation

2002 • 57 citations

The Roles of Metabotropic Glutamate Receptors in Seizures and Epilepsy

2002 • 57 citations

Chapter III Metabotropic glutamate receptors — immunocytochemical and in situ hybridization analyses

2000 • 56 citations

Loss of mGluR-mediated hyperpolarizations and increase in mGluR depolarizations in basolateral amygdala neurons in kindling-induced epilepsy

1996 • 55 citations

Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1α metabotropic glutamate receptor

1998 • 54 citations

Expression of the group I metabotropic glutamate receptor in the hippocampus of patients with mesial temporal lobe epilepsy.

2002 • 54 citations

Specific group II metabotropic glutamate receptor activation inhibits the development of kindled epilepsy in rats

1998 • 54 citations

Reduced function of<scp>l</scp>-AP4-sensitive metabotropic glutamate receptors in human epileptic sclerotic hippocampus

1999 • 52 citations

Long-lasting enhancement of metabotropic excitatory amino acid receptor-mediated polyphosphoinositide hydrolysis in the amygdala/ pyriform cortex of deep prepiriform cortical kindled rats

1992 • 52 citations

Intracerebral 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) produces limbic seizures that are not blocked by ionotropic glutamate receptor antagonists

1993 • 51 citations

Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice

2001 • 50 citations

Epileptic Seizures and Epilepsy

1999 • 48 citations

New Antiepileptic Drugs

1998 • 48 citations

In vitro and in vivo characterization of MPEP, an allosteric modulator of the metabotropic glutamate receptor subtype 5: Review article

2002 • 47 citations

Modulation of seizure activity in mice by metabotropic glutamate receptor ligands.

1996 • 47 citations

Anticonvulsant activity of a metabotropic glutamate receptor 8 preferential agonist, (R,S)-4-phosphonophenylglycine

1999 • 45 citations

Anticonvulsant activity of a mGlu4α receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid

2001 • 44 citations

Attenuation of seizures induced by homocysteic acid in immature rats by metabotropic glutamate group II and group III receptor agonists

2001 • 44 citations

Long‐term potentiation of mGluR1 activity by depolarization‐induced Homer1a in mouse cerebellar Purkinje neurons

2003 • 42 citations

Lasting increase in excitatory amino acid receptor-mediated polyphosphoinositide hydrolysis in the amygdala/pyriform cortex of amygdala-kindled rats

1989 • 41 citations

The effects of AMPA receptor antagonists on kindled seizures and on reflex epilepsy in rodents and primates.

1992 • 39 citations

Anticonvulsant action of metabotropic glutamate receptor agonists in kindled amygdala of rats

1996 • 38 citations

Inhibition of group I metabotropic glutamate receptor responses in vivo in rats by a new generation of carboxyphenylglycine-like amino acid antagonists

2002 • 37 citations

Seizures induced by homocysteic acid in immature rats are prevented by group III metabotropic glutamate receptoragonist (R,S)-4-phosphonophenylglycine

2003 • 36 citations

Decreased sensitivity to Group III mGluR agonists in the lateral perforant path following kindling

1999 • 34 citations

Long-lasting increase in protein kinase C activity in the hippocampus of amygdala-kindled rat

1995 • 33 citations

Epileptogenesis Up-Regulates Metabotropic Glutamate Receptor Activation of Sodium-Calcium Exchange Current in the Amygdala

2000 • 32 citations

Role of glutamate and aspartate in epileptogenesis; contribution of microdialysis studies in animal and man.

1996 • 31 citations

Novel, centrally active mGlu1 antagonists: In vitro and in vivo pharmacology

2002 • 31 citations

Group I mGluRs modulate the pattern of non-synaptic epileptiform activity in the hippocampus

2002 • 31 citations

Emerging Signalling and Protein Interactions Mediated Via Metabotropic Glutamate Receptors

2003 • 30 citations

Metabotropic glutamate receptor 8 in the rat hippocampus after pilocarpine induced status epilepticus

2001 • 30 citations

Kindled seizures increase metabotropic glutamate receptor expression and function in the rat supraoptic nucleus

1998 • 28 citations

Down‐regulation of mGluR8 in pilocarpine epileptic rats

2003 • 27 citations

AIDA, a Class I Metabotropic Glutamate‐receptor Antagonist Limits Kainate‐induced Hippocampal Dysfunction

2002 • 26 citations

Kainate-induced status epilepticus leads to a delayed increases in various specific glutamate metabotropic receptor responses in the hippocampus

1994 • 24 citations

Expression of metabotropic glutamate receptor 1α in the hippocampus of rat pilocarpine model of status epilepticus

2001 • 24 citations

Topiramate potentiates the antiseizure activity of some anticonvulsants in DBA/2 mice

2000 • 24 citations

Selective group II glutamate metabotropic receptor agonist LY354740 attenuates pentetrazole- and picrotoxin-induced seizures.

2000 • 24 citations

The mGlu2/3 agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate, is anti- and proconvulsant in DBA/2 mice

2001 • 23 citations

Polyamine metabolism and glutamate receptor agonists‐mediated excitotoxicity in the rat brain

2001 • 23 citations

Determination of group I metabotropic glutamate receptor subtypes involved in the frequency of epileptiform activity in vitro using mGluR1 and mGluR5 mutant mice

2003 • 21 citations

1,4-Benzodiazepine derivatives as anticonvulsant agents in DBA/2 mice

1996 • 19 citations

Elevated levels of group‐III metabotropic glutamate receptors in the inferior colliculus of genetically epilepsy‐prone rats following intracollicular administration of <scp>l</scp>‐serine‐O‐phosphate

2001 • 19 citations

Inhibition of Hippocampal Kindling by Metabotropic Glutamate Receptor Antisense Oligonucleotides

2000 • 17 citations

Analysing metabotropic glutamate group III receptor mediated modulation of synaptic transmission in the amygdala-kindled dentate gyrus of the rat

1999 • 16 citations

Complex interactions between mGluR1 and mGluR5 shape neuronal network activity in the rat hippocampus

2002 • 15 citations

Group III mGlu receptor agonists potentiate the anticonvulsant effect of AMPA and NMDA receptor block

2002 • 13 citations