The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

1999 • 1,055 citations

Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats

1998 • 1,002 citations

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype

2000 • 933 citations

Molecular and Neuronal Substrate for the Selective Attenuation of Anxiety

2000 • 927 citations

Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors

2000 • 880 citations

Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala

1990 • 806 citations

Neurotransmission in the rat amygdala related to fear and anxiety

1994 • 781 citations

Metabotropic glutamate receptors: electrophysiological properties and role in plasticity

1999 • 770 citations

Fear-potentiated startle: A neural and pharmacological analysis

1993 • 736 citations

Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system.

2001 • 678 citations

Neurobiology of fear responses: the role of the amygdala

1997 • 556 citations

Anticonvulsant activity of (+)‐5‐methyl‐10, 11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 496 citations

The role of the amygdala in fear-potentiated startle: implications for animal models of anxiety

1992 • 425 citations

Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

1997 • 389 citations

Use of Benzodiazepines in Anxiety Disorders

1993 • 333 citations

Amygdalar NMDA Receptors are Critical for New Fear Learning in Previously Fear-Conditioned Rats

1998 • 309 citations

Inhibitory transmission in the basolateral amygdala

1991 • 284 citations

Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors.

1998 • 277 citations

Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex.

2000 • 275 citations

Diazepam and flurazepam: Effects on conditioned fear as measured with the potentiated startle paradigm

1979 • 267 citations

The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats.

1999 • 266 citations

LY354740 is a Potent and Highly Selective Group II Metabotropic Glutamate Receptor Agonist in Cells Expressing Human Glutamate Receptors

1997 • 223 citations

In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY354740 in rats

1997 • 165 citations

Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle

1993 • 164 citations

Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models

1999 • 130 citations

LY354740, a potent group II metabotropic glutamate receptor agonist prevents lactate-induced panic-like response in panic-prone rats

2000 • 119 citations

2-Substituted (2SR)-2-Amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as Potent and Selective Antagonists of Group II Metabotropic Glutamate Receptors. 2. Effects of Aromatic Substitution, Pharmacological Characterization, and Bioavailability

1998 • 99 citations

Serotonin does not mediate anxiolytic effects of buspirone in the fear-potentiated startle paradigm: comparison with 8-OH-DPAT and ipsapirone

1988 • 95 citations

Differential control of GABA release at synapses from distinct interneurons in rat hippocampus

2000 • 83 citations

Cocaine and Kindling Alter the Sensitivity of Group II and III Metabotropic Glutamate Receptors in the Central Amygdala

2000 • 77 citations

Metabotropic glutamate receptor agonist-induced hyperpolarizations in rat basolateral amygdala neurons: receptor characterization and ion channels

1996 • 47 citations

Interactions between LY354740, a Group II metabotropic agonist and the GABAA-benzodiazepine receptor complex in the rat elevated plus-maze

2001 • 47 citations

Drug mechanisms in anxiety.

2001 • 25 citations

Behavioral pharmacology of N-methyl-d-aspartate antagonists: Implications for the study and pharmacology of anxiety and schizophrenia.

1997 • 23 citations

Effects of the group II metabotropic glutamate receptor agonist, LY354740 on schedule-controlled behaviour in rats

1999 • 18 citations

Disinhibitory effects of LY354740, a new mGluR2 agonist, on behaviors suppressed by electric shock in rats and pigeons

1999 • 16 citations