Generation of gut‐homing T cells and their localization to the small intestinal mucosa

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

2001 • 2,472 citations

CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

1999 • 2,326 citations

A human retinoic acid receptor which belongs to the family of nuclear receptors

1987 • 2,245 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

CX ₃ CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance

2005 • 1,534 citations

Nuclear receptor that identifies a novel retinoic acid response pathway

1990 • 1,529 citations

Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria

2004 • 1,520 citations

A cell-surface molecule involved in organ-specific homing of lymphocytes

1983 • 1,515 citations

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

1992 • 1,514 citations

Retinoic Acid Imprints Gut-Homing Specificity on T Cells

2004 • 1,460 citations

T-Cell Function and Migration — Two Sides of the Same Coin

2000 • 1,437 citations

α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1

1993 • 1,427 citations

Immune cell migration in inflammation: present and future therapeutic targets

2005 • 1,262 citations

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.

1992 • 1,200 citations

Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the αEβ7 integrin

1994 • 1,131 citations

Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells

2003 • 1,058 citations

Embryonic retinoic acid synthesis is essential for early mouse post-implantation development

1999 • 1,051 citations

Identification of a second human retinoic acid receptor

1988 • 1,049 citations

α4 integrins mediate lymphocyte attachment and rolling under physiologic flow

1995 • 1,018 citations

Chemokines and the Arrest of Lymphocytes Rolling Under Flow Conditions

1998 • 1,013 citations

A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes

1998 • 1,001 citations

CCR7 Governs Skin Dendritic Cell Migration under Inflammatory and Steady-State Conditions

2004 • 997 citations

A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes

2000 • 908 citations

Overview of retinoid metabolism and function

2006 • 885 citations

Regulation of Dendritic Cell Migration to the Draining Lymph Node

2003 • 863 citations

Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice

1994 • 835 citations

Cloning of murine α and β retinoic acid receptors and a novel receptor γ predominantly expressed in skin

1989 • 804 citations

CCL27–CCR10 interactions regulate T cell–mediated skin inflammation

2002 • 773 citations

Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.

1993 • 738 citations

Transcytosis and Surface Presentation of IL-8 by Venular Endothelial Cells

1997 • 731 citations

Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis.

1991 • 730 citations

A tissue-specific endothelial cell molecule involved in lymphocyte homing

1988 • 725 citations

Treatment of Ulcerative Colitis with a Humanized Antibody to the α₄β₇Integrin

2005 • 692 citations

A third human retinoic acid receptor, hRAR-gamma.

1989 • 686 citations

Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells

2006 • 676 citations

THE ROUTE OF ENTERIC INFECTION IN NORMAL MICE

1974 • 661 citations

Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing

2005 • 651 citations

A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo

2000 • 643 citations

Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes.

1988 • 639 citations

Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo.

1994 • 625 citations

Lymphocyte Cc Chemokine Receptor 9 and Epithelial Thymus-Expressed Chemokine (Teck) Expression Distinguish the Small Intestinal Immune Compartment

2000 • 620 citations

A new retinoic acid receptor identified from a hepatocellular carcinoma

1988 • 613 citations

Estimating the Precursor Frequency of Naive Antigen-specific CD8 T Cells

2002 • 584 citations

Localization of Distinct Peyer's Patch Dendritic Cell Subsets and Their Recruitment by Chemokines Macrophage Inflammatory Protein (Mip)-3α, Mip-3β, and Secondary Lymphoid Organ Chemokine

2000 • 578 citations

Families of retinoid dehydrogenases regulating vitamin A function

2000 • 573 citations

Critical role for β7 integrins in formation of the gut-associated lymphoid tissue

1996 • 558 citations

L-selectin-mediated lymphocyte rolling on MAdCAM-1

1993 • 540 citations

Epithelial M Cells: Gateways for Mucosal Infection and Immunization

1996 • 536 citations

Distinct roles of L-selectin and integrins α4β7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: The multistep model confirmed and refined

1995 • 520 citations

CC Chemokine Receptor (CCR)4 and the CCR10 Ligand Cutaneous T Cell–attracting Chemokine (CTACK) in Lymphocyte Trafficking to Inflamed Skin

2001 • 502 citations

Human G Protein–Coupled Receptor Gpr-9-6/Cc Chemokine Receptor 9 Is Selectively Expressed on Intestinal Homing T Lymphocytes, Mucosal Lymphocytes, and Thymocytes and Is Required for Thymus-Expressed Chemokine–Mediated Chemotaxis

1999 • 492 citations

Rapid Acquisition of Tissue-specific Homing Phenotypes by CD4+ T Cells Activated in Cutaneous or Mucosal Lymphoid Tissues

2002 • 490 citations

CCR6 Mediates Dendritic Cell Localization, Lymphocyte Homeostasis, and Immune Responses in Mucosal Tissue

2000 • 485 citations

Intraepithelial lymphocytes: exploring the Third Way in immunology

2001 • 481 citations

Essential role for CD103 in the T cell–mediated regulation of experimental colitis

2005 • 474 citations

Molecular Mechanisms of Lymphocyte Homing to Peripheral Lymph Nodes

1998 • 469 citations

ANTIGEN SAMPLING ACROSS EPITHELIAL BARRIERS AND INDUCTION OF MUCOSAL IMMUNE RESPONSES

1996 • 462 citations

A monoclonal antibody (HML‐1) defining a novel membrane molecule present on human intestinal lymphocytes

1987 • 461 citations

Identification of Multiple Isolated Lymphoid Follicles on the Antimesenteric Wall of the Mouse Small Intestine

2002 • 460 citations

A Major Lung CD103 (αE)-β7 Integrin-Positive Epithelial Dendritic Cell Population Expressing Langerin and Tight Junction Proteins

2006 • 457 citations

Intestinal villous M cells: An antigen entry site in the mucosal epithelium

2004 • 455 citations

Selective Generation of Gut Tropic T Cells in Gut-associated Lymphoid Tissue (GALT)

2003 • 448 citations

Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice.

1999 • 428 citations

Unique Functions of CD11b+, CD8α+, and Double-Negative Peyer’s Patch Dendritic Cells

2001 • 408 citations

CCR7 Is Critically Important for Migration of Dendritic Cells in Intestinal Lamina Propria to Mesenteric Lymph Nodes

2006 • 401 citations

Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thy1+ lympho-hemopoietic progenitors develop.

1996 • 400 citations

Control of lymphocyte recirculation in man. II. Differential regulation of the cutaneous lymphocyte-associated antigen, a tissue-selective homing receptor for skin-homing T cells.

1993 • 393 citations

Mucosal T Lymphocyte Numbers Are Selectively Reduced in Integrin αE (CD103)-Deficient Mice

1999 • 377 citations

The Ccr7 Ligand ELC (Ccl19) Is Transcytosed in High Endothelial Venules and Mediates T Cell Recruitment

2001 • 367 citations

Monoclonal antibodies specific for beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of scid mice reconstituted with CD45RBhigh CD4+ T cells.

1997 • 364 citations

The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9

2000 • 358 citations

Control of lymphocyte recirculation in man. I. Differential regulation of the peripheral lymph node homing receptor L-selectin on T cells during the virgin to memory cell transition.

1993 • 349 citations

The Role of Thymus-Expressed Chemokine and Its Receptor CCR9 on Lymphocytes in the Regional Specialization of the Mucosal Immune System

2000 • 336 citations

6-C-kine (SLC), a Lymphocyte Adhesion-triggering Chemokine Expressed by High Endothelium, Is an Agonist for the MIP-3β Receptor CCR7

1998 • 331 citations

Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin alpha 4 beta 7

1996 • 329 citations

CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells

2003 • 328 citations

A Role for CCR9 in T Lymphocyte Development and Migration

2002 • 321 citations

Intestinal dendritic cells increase T cell expression of α4β7 integrin

2002 • 309 citations

The human peripheral lymph node vascular addressin is a ligand for LECAM-1, the peripheral lymph node homing receptor.

1991 • 307 citations

A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment

2003 • 307 citations

Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues

2005 • 307 citations

H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element.

1989 • 306 citations

Evidence for an accessory role of LFA-1 in lymphocyte-high endothelium interaction during homing.

1988 • 302 citations

TECK: A Novel CC Chemokine Specifically Expressed by Thymic Dendritic Cells and Potentially Involved in T Cell Development

1997 • 292 citations

Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor γδ+ gut intraepithelial lymphocytes

2001 • 291 citations

Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo.

1993 • 284 citations

Increased Expression of IP-10, IL-8, MCP-1, and MCP-3 in Ulcerative Colitis

1999 • 280 citations

Rapid G protein-regulated activation event involved in lymphocyte binding to high endothelial venules.

1993 • 271 citations

CCL25 mediates the localization of recently activated CD8αβ+ lymphocytes to the small-intestinal mucosa

2002 • 258 citations

Fractalkine Is an Epithelial and Endothelial Cell-Derived Chemoattractant for Intraepithelial Lymphocytes in the Small Intestinal Mucosa

2000 • 252 citations

TGF-β–dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease

2005 • 249 citations

CCR6-Mediated Dendritic Cell Activation of Pathogen-Specific T Cells in Peyer's Patches

2006 • 245 citations

Expression of the Chemokine Receptors CCR4, CCR5, and CXCR3 by Human Tissue-Infiltrating Lymphocytes

2002 • 244 citations

Cytosolic retinoid dehydrogenases govern ubiquitous metabolism of retinol to retinaldehyde followed by tissue-specific metabolism to retinoic acid

2003 • 238 citations

Down-regulation of homing receptors after T cell activation.

1988 • 235 citations

Immunomodulatory dendritic cells in intestinal lamina propria

2005 • 224 citations

Chemokine Receptor CCR9 Contributes to the Localization of Plasma Cells to the Small Intestine

2004 • 222 citations

CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses

2001 • 218 citations

The MRC OX-62 antigen: a useful marker in the purification of rat veiled cells with the biochemical properties of an integrin.

1992 • 217 citations

A new surface antigen on intraepithelial lymphocytes in the intestine

1990 • 216 citations

Two distinct pools of recirculating T lymphocytes: migratory characteristics of nodal and intestinal T lymphocytes.

1977 • 213 citations

A Skin-selective Homing Mechanism for Human Immune Surveillance T Cells

2004 • 212 citations

The Role of β7 Integrins in CD8 T Cell Trafficking During an Antiviral Immune Response

1999 • 211 citations

Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cells

2001 • 209 citations

CD134L Expression on Dendritic Cells in the Mesenteric Lymph Nodes Drives Colitis in T Cell-Restored SCID Mice

2001 • 207 citations

CC Chemokine Ligands 25 and 28 Play Essential Roles in Intestinal Extravasation of IgA Antibody-Secreting Cells

2004 • 202 citations

Starting at the Beginning: New Perspectives on the Biology of Mucosal T Cells

2004 • 200 citations

The role of enterocytes in the intestinal barrier function and antigen uptake

2005 • 197 citations

Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation

2000 • 196 citations

Cryptopatches and isolated lymphoid follicles: dynamic lymphoid tissues dispensable for the generation of intraepithelial lymphocytes

2004 • 183 citations

Transepithelial Pathogen Uptake into the Small Intestinal Lamina Propria

2006 • 182 citations

Gut-associated lymphoid tissue–primed CD4+ T cells display CCR9-dependent and -independent homing to the small intestine

2006 • 173 citations

Dendritic cells govern induction and reprogramming of polarized tissue‐selective homing receptor patterns of T cells: important roles for soluble factors and tissue microenvironments

2005 • 171 citations

Tissue-tropic effector T cells: generation and targeting opportunities

2006 • 171 citations

CD4+ T Cells Migrate into Inflamed Skin Only If They Express Ligands for E- and P-Selectin

1998 • 169 citations

The Transmembrane Form of the CX3CL1 Chemokine Fractalkine Is Expressed Predominantly by Epithelial Cells in Vivo

2001 • 168 citations

DIFFERENTIALIN SITU EXPRESSION OF THE GENES ENCODING THE CHEMOKINES MCP-1 AND RANTES IN HUMAN INFLAMMATORY BOWEL DISEASE

1996 • 166 citations

A recombinant Salmonella typhimurium vaccine strain is taken up and survives within murine Peyer's patch dendritic cells

2000 • 157 citations

Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation

2000 • 155 citations

Studies on the lymphocytes of sheep. Destination of lymph‐borne immunoblasts in relation to their tissue of origin

1977 • 153 citations

Expression of mucosal homing receptor alpha4beta7 by circulating CD4+ cells with memory for intestinal rotavirus.

1997 • 149 citations

Peyer's Patch Dendritic Cells Process Viral Antigen from Apoptotic Epithelial Cells in the Intestine of Reovirus-infected Mice

2004 • 146 citations

Lymphocyte-filled villi: Comparison with other lymphoid aggregations in the mucosa of the human small intestine

1998 • 141 citations

Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3

2002 • 140 citations

Amelioration of murine experimental colitis by inhibition of mucosal addressin cell adhesion molecule-1.

2000 • 133 citations

Dynamic Programing of CD8+ T Cell Trafficking after Live Viral Immunization

2006 • 128 citations

Transendothelial migration and trafficking of leukocytes in LFA-1-deficient mice

1998 • 125 citations

Intestinal Dendritic Cell Subsets: Differential Effects of Systemic TLR4 Stimulation on Migratory Fate and Activation In Vivo

2005 • 122 citations

Human intestinal lamina propria lymphocytes are naturally permissive to HIV-1 infection

1999 • 113 citations

Expression of CCR9 β-chemokine receptor is modulated in thymocyte differentiation and is selectively maintained in CD8+ T cells from secondary lymphoid organs

2001 • 109 citations

Distribution of α₄β₇ and α_Eβ₇ integrins on thymocytes, intestinal epithelial lymphocytes and peripheral lymphocytes

1996 • 106 citations

Identical T Cell Clones Are Located within the Mouse Gut Epithelium and Lamina Propria and Circulate in the Thoracic Duct Lymph

2000 • 106 citations

In Vivo Adjuvant-Induced Mobilization and Maturation of Gut Dendritic Cells after Oral Administration of Cholera Toxin

2004 • 105 citations

CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epithelium

2006 • 105 citations

Characterization of epithelial chemoattractants for human intestinal intraepithelial lymphocytes

2001 • 103 citations

Characterization of CCR9 Expression and CCL25/Thymus-Expressed Chemokine Responsiveness During T Cell Development: CD3highCD69+ Thymocytes and γδTCR+ Thymocytes Preferentially Respond to CCL25

2002 • 102 citations

Lymph-borne (veiled) dendritic cells can acquire and present intestinally administered antigens.

1991 • 102 citations

Murine CCR9, a Chemokine Receptor for Thymus-Expressed Chemokine That Is Up-Regulated Following Pre-TCR Signaling

2000 • 101 citations

Redundant Role of Chemokines CCL25/TECK and CCL28/MEC in IgA+ Plasmablast Recruitment to the Intestinal Lamina Propria After Rotavirus Infection

2006 • 98 citations

Selection and Expansion of CD8α/α1 T Cell Receptor α/β1 Intestinal Intraepithelial Lymphocytes in the Absence of Both Classical Major Histocompatibility Complex Class I and Nonclassical Cd1 Molecules

1999 • 97 citations

Demonstration of functional role of TECK/CCL25 in T lymphocyte-endothelium interaction in inflamed and uninflamed intestinal mucosa

2004 • 93 citations

Regulation of lymphocyte homing. I. Alterations in homing receptor expression and organ-specific high endothelial venule binding of lymphocytes upon activation.

1988 • 90 citations

CCL25/CCR9 promotes the induction and function of CD103 on intestinal intraepithelial lymphocytes

2004 • 90 citations

The Membrane-Bound Chemokine CXCL16 Expressed on Follicle-Associated Epithelium and M Cells Mediates Lympho-Epithelial Interaction in GALT

2006 • 87 citations

Lamina Propria Lymphocytes, Not Macrophages, Express CCR5 and CXCR4 and Are the Likely Target Cell for Human Immunodeficiency Virus Type 1 in the Intestinal Mucosa

2000 • 86 citations

Site‐specific expression of CD11b and SIRPα (CD172a) on dendritic cells: implications for their migration patterns in the gut immune system

2005 • 86 citations

Expression of the Mucosal Homing Receptor α₄β₇Correlates with the Ability of CD8⁺Memory T Cells To Clear Rotavirus Infection

1998 • 83 citations

The Chemokine Stromal Cell-Derived Factor-1α Modulates α4β7 Integrin-Mediated Lymphocyte Adhesion to Mucosal Addressin Cell Adhesion Molecule-1 and Fibronectin

2002 • 82 citations

In Vivo Roles of Integrins During Leukocyte Development and Traffic: Insights from the Analysis of Mice Chimeric for α5, αv, and α4 Integrins

2000 • 81 citations

CCR5 mediates specific migration of Toxoplasma gondii—primed CD8+ lymphocytes to inflammatory intestinal epithelial cells

2003 • 81 citations

Expression of the VLA family of integrins in human intestine

1990 • 80 citations

Integrin αE(CD103)β7 Mediates Adhesion to Intestinal Microvascular Endothelial Cell Lines Via an E-Cadherin-Independent Interaction

2001 • 73 citations

Visualization of peptide presentation following oral application of antigen in normal and Peyer's patches‐deficient mice

2003 • 73 citations

Cutting edge: TCR alpha beta+ CD8 alpha alpha+ T cells are found in intestinal intraepithelial lymphocytes of mice that lack classical MHC class I molecules.

1999 • 70 citations

Development of Cd8α/α and Cd8α/β T Cells in Major Histocompatibility Complex Class I–Deficient Mice

1999 • 68 citations

Phenotypic heterogeneity of intraepithelial T lymphocytes from mouse small intestine.

1991 • 67 citations

Functional Characterization of the CCL25 Promoter in Small Intestinal Epithelial Cells Suggests a Regulatory Role for Caudal-Related Homeobox (Cdx) Transcription Factors

2006 • 65 citations

Cutting Edge: TCRαβ+ CD8αα+ T Cells Are Found in Intestinal Intraepithelial Lymphocytes of Mice That Lack Classical MHC Class I Molecules

1999 • 65 citations

Tissue targeting of T cells by DCs and microenvironments

2004 • 64 citations

Expression of the mucosal T cell integrin αM290β7 by a major subpopulation of dendritic cells in mice

1993 • 63 citations

Mucosal angiogenesis regulation by CXCR4 and its ligand CXCL12 expressed by human intestinal microvascular endothelial cells

2004 • 63 citations

Development of CD8 alpha alpha+ intestinal intraepithelial T cells in beta 2-microglobulin- and/or TAP1-deficient mice.

1996 • 62 citations

TAP-independent selection of CD8+ intestinal intraepithelial lymphocytes.

1996 • 61 citations

α4β7 independent pathway for CD8+ T cell–mediated intestinal immunity to rotavirus

2000 • 59 citations

Chemokines in inflammatory bowel disease mucosa: Expression of RANTES, macrophage inflammatory protein (MIP)-1α, MIP-1β, and γ-interferon–inducible protein-10 by macrophages, lymphocytes, endothelial cells, and granulomas

1996 • 56 citations

Reduced Gut Intraepithelial Lymphocytes in VLA1 Null Mice

2000 • 55 citations

Dramatic increase in lymph node dendritic cell number during infection by the mouse mammary tumor virus occurs by a CD62L-dependent blood-borne DC recruitment

2002 • 55 citations

In vivodemonstration of T lymphocyte migration and amelioration of ileitis in intestinal mucosa of SAMP1/Yit mice by the inhibition of MAdCAM-1

2005 • 53 citations

Involvement of CCL25 (TECK) in the generation of the murine small-intestinal CD8? ?+CD3+ intraepithelial lymphocyte compartment

2002 • 50 citations

Integrin α₁β₁ (VLA‐1) mediates adhesion of activated intraepithelial lymphocytes to collagen

1999 • 49 citations

Lymphoid Precursors in Intestinal Cryptopatches Express CCR6 and Undergo Dysregulated Development in the Absence of CCR6

2003 • 48 citations

Involvement of α1 and α4 integrins in gut mucosal injury of graft-versus-host disease

1995 • 47 citations

Murine CD8+ Recent Thymic Emigrants are αE Integrin-Positive and CC Chemokine Ligand 25 Responsive

2004 • 33 citations

CXCR3 and E 7 integrin identify a subset of CD8+ mature thymocytes that share phenotypic and functional properties with CD8+ gut intraepithelial lymphocytes

2005 • 28 citations

Age‐Related Changes in CCR9⁺ Circulating Lymphocytes: Are CCR9⁺ Naive T Cells Recent Thymic Emigrants?

2001 • 27 citations

Human Intestinal Intraepithelial Lymphocytes Bind to Mucosal Mesenchymal Cells through VLA4 and CD11A

1996 • 15 citations

β1 integrins are not required for the maintenance of lymphocytes within intestinal epithelia

2005 • 8 citations