Mechanisms of DNA double strand break repair and chromosome aberration formation

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

1998 • 1,202 citations

Sensing and repairing DNA double-strand breaks

2002 • 1,112 citations

The DNA-dependent protein kinase

1999 • 896 citations

Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death

1998 • 793 citations

Increased ratio of targeted to random integration after transfection of chicken B cell lines

1991 • 534 citations

Absence of p350 Subunit of DNA-Activated Protein Kinase from a Radiosensitive Human Cell Line

1995 • 530 citations

Mechanisms of nonhomologous recombination in mammalian cells.

1985 • 314 citations

Enzymatic Restriction of Mammalian Cell DNA Using Pvu II and Bam H1: Evidence for the Double-strand Break Origin of Chromosomal Aberrations

1984 • 313 citations

Chromosomal aberrations: formation, identification and distribution

2002 • 310 citations

DNA end-joining catalyzed by human cell-free extracts

1998 • 291 citations

Reduced X-Ray Resistance and Homologous Recombination Frequencies in a RAD54 Mutant of the Chicken DT40 Cell Line

1997 • 277 citations

The Rad51 Paralog Rad51B Promotes Homologous Recombinational Repair

2000 • 263 citations

Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

2001 • 251 citations

DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus.

2000 • 249 citations

Biochemical evidence for Ku-independent backup pathways of NHEJ

2003 • 245 citations

Double-strand breaks and tumorigenesis

2001 • 243 citations

Double-strand break repair in Ku86- and XRCC4-deficient cells

1998 • 235 citations

Homologous Recombination, but Not DNA Repair, Is Reduced in Vertebrate Cells Deficient in RAD52

1998 • 226 citations

Chromosome aberrations: past, present and future

2002 • 212 citations

Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: joining of correct and incorrect ends.

1995 • 193 citations

Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells

2002 • 185 citations

Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group

2001 • 174 citations

Isolation of Two Cell Lines from a Human Malignant Glioma Specimen Differing in Sensitivity to Radiation and Chemotherapeutic Drugs

1993 • 165 citations

Tying up loose ends: nonhomologous end-joining in Saccharomyces cerevisiae

2000 • 164 citations

Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction

2002 • 141 citations

Use of Restriction Endonucleases to Study Relationships between DNA Double-strand Breaks, Chromosomal Aberrations and Other End-points in Mammalian Cells

1988 • 112 citations

Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells

2001 • 107 citations

Homologous recombination as a potential target for caffeine radiosensitization in mammalian cells: reduced caffeine radiosensitization in XRCC2 and XRCC3 mutants

2000 • 98 citations

Chromosome Breaks and Genomic Instability

2000 • 88 citations

The nature and repair of DNA lesions that lead to chromosomal aberrations induced by ionizing radiations

1986 • 87 citations

Characterization of the DNA double strand break repair defect in scid mice.

1993 • 87 citations

Nonhomologous DNA end joining in cell-free systems

1999 • 74 citations

Frameshift Mutation inPRKDC, the Gene for DNA-PKcs, in the DNA Repair-Defective, Human, Glioma-Derived Cell Line M059J

2001 • 69 citations

Analysis of the defect in DNA end joining in the murine scid mutation.

1992 • 69 citations

The scid Defect Results in Much Slower Repair of DNA Double-Strand Breaks but Not High Levels of Residual Breaks

1997 • 58 citations

Repair of Endonuclease-Induced Double-Strand Breaks in Saccharomyces cerevisiae: Essential Role for Genes Associated with Nonhomologous End-Joining

1999 • 57 citations

Induction and Repair of Chromosome Aberrations in scid Cells Measured by Premature Chromosome Condensation

1996 • 45 citations

Gene conversion in the chicken immunoglobulin locus: A paradigm of homologous recombination in higher eukaryotes

1994 • 38 citations

Construction of a vector containing a site-specific DNA double-strand break with 3-phosphoglycolate termini and analysis of the products of end-joining in CV-1 cells '

1996 • 35 citations

DNA lesions and repair

1996 • 28 citations

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