Use of Restriction Endonucleases to Study Relationships between DNA Double-strand Breaks, Chromosomal Aberrations and Other End-points in Mammalian Cells

The American Journal of Human Genetics

1950 • 5,048 citations

International Journal of Radiation Biology

1959 • 1,730 citations

Cytological detection of mutagen–carcinogen exposure by sister chromatid exchange

1975 • 1,333 citations

Progress in Genetic Toxicology

1978 • 581 citations

The repair of double-strand breaks in DNA: A model involving recombination

1976 • 499 citations

A ubiquitous family of repeated DNA sequences in the human genome

1979 • 420 citations

X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining

1984 • 379 citations

Mechanisms of chromosomal aberration production III. Chemicals and ionizing radiation

1974 • 363 citations

X-ray-sensitive mutants of Chinese hamster ovary cell line isolation and cross-sensitivity to other DNA-damaging agents

1983 • 345 citations

Introduction of macromolecules into cultured mammalian cells by osmotic lysis of pinocytic vesicles

1982 • 320 citations

Enzymatic Restriction of Mammalian Cell DNA Using Pvu II and Bam H1: Evidence for the Double-strand Break Origin of Chromosomal Aberrations

1984 • 313 citations

A method for incorporating macromolecules into adherent cells.

1984 • 307 citations

Molecular mechanisms involved in the production of chromosomal aberrations

1984 • 303 citations

Molecular mechanisms involved in the production of cromosomal aberrations II. Utilization of neurospora endonuclease for the study of aberration production by X-rays in G1 and G2 stages of the cell cycle

1980 • 280 citations

Restriction enzymes and their isoschizomers

1990 • 271 citations

Sites and structure of gamma radiation-induced DNA strand breaks.

1982 • 249 citations

Repair of DNA double-strand breaks in Escherichia coli, which requires recA function and the presence of a duplicate genome

1977 • 240 citations

Radiation Induced Strand Breakage in DNA from Mammalian Cells

1973 • 222 citations

Restoration of ultraviolet-induced unscheduled DNA synthesis of xeroderma pigmentosum cells by the concomitant treatment with bacteriophage T4 endonuclease V and HVJ (Sendai virus).

1975 • 215 citations

Unrepaired DNA strand breaks in irradiated ataxia telangiectasia lymphocytes suggested from cytogenetic observations

1978 • 209 citations

The production and repair of double strand breaks in cells from normal humans and from patients with ataxia telangiectasia

1977 • 203 citations

DNA Double Strand Breaks in Ehrlich Ascites Tumour Cells at Low Doses of X-rays. II. Can Cell Death be Attributed to Double Strand Breaks?

1982 • 200 citations

Induction of DNA double-strand breaks by X-rays in a radiosensitive strain of the yeast Saccharomyces cerevisiae

1975 • 199 citations

Detection and repair of single-strand breaks in nuclear DNA

1976 • 189 citations

Chromosome aberrations and radiation-induced cell death

1973 • 156 citations

Enzymatic Restriction of Mammalian Cell DNA: Evidence for Double-strand Breaks as Potentially Lethal Lesions

1985 • 146 citations

The effect of cytosine arabinoside on the frequency of X-ray-induced chromosome aberrations in normal human leukocytes

1980 • 138 citations

X-ray-induced Chromosome Damage in Live Mammalian Cells, and Improved Measurements of Its Effects on Their Colony-forming Ability

1982 • 135 citations

Potentially Lethal Damage versus Sublethal Damage: Independent Repair Processes in Actively Growing Chinese Hamster Cells

1979 • 129 citations

DNA Double Strand Breaks in Ehrlich Ascites Tumour Cells at Low Doses of X-rays. I. Determination of Induced Breaks by Centrifugation at Reduced Speed

1982 • 123 citations

Measurement of the Kinetics of DNA Double Strand Break Repair in Ehrlich Ascites Tumour Cells Using the Unwinding Method

1980 • 116 citations

Structures and mechanisms of DNA restriction and modification enzymes

1979 • 116 citations

Microinjection of thymidine kinase and bovine serum albumin into mammalian cells by fusion with red blood cells

1975 • 113 citations

Effects of Different Ionizing Radiations on Human Cells in Tissue Culture: IV. Modification of Radiation Damage

1964 • 108 citations

Radiation-induced chromosome damage in X-ray-sensitive mutants (xrs) of the Chinese hamster ovary cell line

1986 • 97 citations

Cytological characterization of Chinese hamster ovary X-ray-sensitive mutant cells xrs 5 and xrs 6

1987 • 93 citations

Ataxia-telangiectasia: a human mutation giving high-frequency misrepair of DNA double-stranded scissions.

1986 • 83 citations

Strand Breaks and 5′ End-groups in DNA of Irradiated Thymocytes

1973 • 82 citations

Repair of DNA double-strand breaks in irradiated yeast cells under nongrowth conditions.

1980 • 82 citations

Microinjection of somatic cells with micropipettes: comparison with other transfer techniques

1984 • 82 citations

Regulated expression of endonuclease EcoRI in Saccharomyces cerevisiae: nuclear entry and biological consequences.

1985 • 78 citations

A model for restriction fragment length distributions.

1983 • 76 citations

Double Strand Rejoining in Mammalian DNA

1973 • 69 citations

The chromosome-breaking activity of the restriction endonuclease Alu I in CHO cells is independent of the S-phase of the cell cycle

1985 • 69 citations

Restriction enzyme banding of mouse metaphase chromosomes

1984 • 66 citations

Repair of DNA Double-Strand Breaks in Irradiated Yeast Cells under Nongrowth Conditions

1980 • 66 citations

Chromosomal aberrations induced by restriction endonucleases

1985 • 63 citations

The induction of chromosome aberrations by restriction endonucleases that produce blunt-end or cohesive-end double-strand breaks

1988 • 61 citations

High Chromosomal Sensitivity of Chinese Hamster Xrs 5 Cells to Restriction Endonuclease Induced DNA Double-strand Breaks

1987 • 60 citations

Induction of sister-chromatid exchanges by restriction endonucleases

1985 • 56 citations

DNAase I encapsulated in liposomes can induce neoplastic transformation of syrian hamster embryo cells in culture

1984 • 54 citations

Restriction enzymes and their isoschizomers

1987 • 53 citations

The application of the microbial “tooth-pick” technique to somatic cell genetics, and its use in the isolation of X-ray sensitive mutants of chinese hamster ovary cells

1982 • 52 citations

Double strand rejoining in mammalian DNA.

1973 • 51 citations

The Use of Recombinant DNA Techniques to Study Radiation-induced Damage, Repair and Genetic Change in Mammalian Cells

1986 • 47 citations

The use of inhibitors of DNA repair in the study of the mechanisms of induction of chromosome aberrations

1982 • 39 citations

Homologous recombination in a Chinese hamster X-ray-sensitive mutant

1986 • 36 citations

Chromosomal aberrations induced by the restriction endonuclease Alu I in chinese hamster ovary cells: influence of duration of treatment and potentiation by cytosine arabinoside

1985 • 33 citations

Repair of DNA single-strand and double-strand breaks in the Chinese hamster xrs 5 mutant cell line as determined by DNA unwinding

1988 • 32 citations

Modification of End-groups in DNA Strand Breaks of Irradiated Thymocytes during Early Repair

1975 • 32 citations

Molecular biology in medicine

1982 • 30 citations

Effects of hypertonic sucrose on the radiosensitivity of Chinese hamster fibroblasts

1969 • 30 citations

Degradation of non-replicating bacteriophage DNA in non-accepting cells

1964 • 30 citations

The restriction endonuclease Alu I induces chromosomal aberrations and mutations in the hypoxanthine phosphoribosyltransferase locus, but not in the Na+/K+ ATPase locus in V79 hamster cells

1986 • 29 citations

Restriction endonuclease Bam H I induces chromosomal aberrations in Chinese hamster ovary (CHO) cells

1986 • 28 citations

The Effect of Hypertonic Shock on the Radiation Response of HeLa-3 Cells

1972 • 26 citations

Alterations in the Radiosensitivity of CHO Cells by Anisotonic Treatments: Correlations between Cell Lethality and Chromosomal Aberrations

1979 • 26 citations

Influence of bromodeoxyuridine substitution of thymidine on sister-chromatid exchanges and chromosomal aberrations induced by restriction endonucleases

1986 • 24 citations

The restriction endonuclease Alu I induces chromosomal aberrations in human peripheral lymphocytes in vitro

1986 • 21 citations

How does EcoRI cleave its recognition site on DNA?

1983 • 21 citations

Cleavage of plant chromosomes by restriction endonucleases

1976 • 18 citations

Elevation of Alu I-induced frequencies of chromosomal aberrations in Chinese hamster ovary cells by Neurospora crassa endonuclease and by ammonium sulfate

1986 • 16 citations

Chromosomal aberrations induced by the restriction endonucleases Alu I and Bam HI: Comparison with X-rays.

1987 • 14 citations

Comparison between inactivated Sendai virus, polyethylene glycol and Tween 80 as permeabilizing agents for introduction of neurospora endonuclease into x-irradiated cells

1980 • 12 citations

Evidence for a receptor-mediated endocytosis of Alu I in Chinese hamster ovary cells

1988 • 11 citations

Chromosomal aberrations induced by the restriction endonucleases EcoR I, Pst I, Sal I and Bam HI in CHO cells

1987 • 10 citations

Kinetics of recombinational hybrid formation in X-irradiated mammalian cells: a possible first step in the repair of DNA double-strand breaks

1984 • 9 citations

TRANSIENT CHANGES IN PERMEABILITY IN HeLa AND L CELLS DURING DETACHMENT FROM A SUBSTRATE

1987 • 9 citations

Failure to Detect a DNA Repair-related Defect in the Transfection of Ataxia-telangiectasia Cells by Enzymatically Restricted Plasmid

1987 • 8 citations

Mutation research. DNA repair reports

1988 • 2 citations