Phases of apoptosis of melanoma cells, but not of normal melanocytes, differently affect maturation of myeloid dendritic cells.

Dendritic cells and the control of immunity

1998 • 14,345 citations

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

1996 • 1,908 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming

2001 • 1,538 citations

A receptor for phosphatidylserine-specific clearance of apoptotic cells

2000 • 1,480 citations

Consequences of Cell Death

2000 • 1,382 citations

Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway

2000 • 1,299 citations

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

1998 • 1,226 citations

Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes.

1994 • 850 citations

Dynamics of T Lymphocyte Responses: Intermediates, Effectors, and Memory Cells

2000 • 807 citations

CD91: a receptor for heat shock protein gp96

2000 • 673 citations

Cutting Edge: Secondary Lymphoid-Tissue Chemokine (SLC) and CC Chemokine Receptor 7 (CCR7) Participate in the Emigration Pathway of Mature Dendritic Cells from the Skin to Regional Lymph Nodes

1999 • 621 citations

Regulatory Activity of Autocrine IL-10 on Dendritic Cell Functions

2001 • 562 citations

Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression.

1995 • 552 citations

IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages

1998 • 505 citations

Interleukin-10–Treated Human Dendritic Cells Induce a Melanoma-Antigen–Specific Anergy in CD8+ T Cells Resulting in a Failure to Lyse Tumor Cells

1999 • 499 citations

Transport of Peptide-MHC Class II Complexes in Developing Dendritic Cells

2000 • 483 citations

Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression

1998 • 449 citations

Processing of Some Antigens by the Standard Proteasome but Not by the Immunoproteasome Results in Poor Presentation by Dendritic Cells

2000 • 418 citations

An HLA-A2-restricted tyrosinase antigen on melanoma cells results from posttranslational modification and suggests a novel pathway for processing of membrane proteins.

1996 • 416 citations

TGF-beta 1 prevents the noncognate maturation of human dendritic Langerhans cells.

1999 • 379 citations

Cross-Priming of Naive Cd8 T Cells against Melanoma Antigens Using Dendritic Cells Loaded with Killed Allogeneic Melanoma Cells

2000 • 292 citations

Processing of engulfed apoptotic bodies yields T cell epitopes.

1997 • 267 citations

Interleukin-10 is a growth factor for human melanoma cells and down-regulates HLA class-I, HLA class-II and ICAM-1 molecules

1997 • 239 citations

Dendritic Cells Capture Killed Tumor Cells and Present Their Antigens to Elicit Tumor-Specific Immune Responses

2000 • 237 citations

Generation of tumor-specific T-lymphocytes by cross-priming with human dendritic cells ingesting apoptotic tumor cells.

2000 • 222 citations

Constitutive Expression of Multiple Growth Factor Genes by Melanoma Cells but Not Normal Melanocytes

1991 • 176 citations

RETROVIRAL DELIVERY OF VIRAL INTERLEUKIN-10 INTO MYELOID DENDRITIC CELLS MARKEDLY INHIBITS THEIR ALLOSTIMULATORY ACTIVITY AND PROMOTES THE INDUCTION OF T-CELL HYPORESPONSIVENESS1,2

1998 • 163 citations

Dendritic cells containing apoptotic melanoma cells prime human CD8+ T cells for efficient tumor cell lysis.

2000 • 162 citations

Dendritic cells acquire the MAGE-3 human tumor antigen from apoptotic cells and induce a class I-restricted T cell response

2000 • 152 citations

Elevated serum levels of interleukin-10 in patients with metastatic malignant melanoma

1995 • 138 citations

Migration of Langerhans cells and dermal dendritic cells in skin organ cultures: augmentation by TNF-α and IL-1 β

1999 • 121 citations

The monoclonal antibody CR11-351 discriminates HLA-A2 variants identified by T cells

1983 • 120 citations

Interleukin-10 production in malignant melanoma: Preferential detection of IL-10-secreting tumor cells in metastatic lesions

1996 • 105 citations

Autologous dendritic cells derived from CD34+ progenitors and from monocytes are not functionally equivalent antigen-presenting cells in the induction of melan-A/Mart-1(27-35)-specific CTLs from peripheral blood lymphocytes of melanoma patients with low frequency of CTL precursors.

1997 • 104 citations

Antiapoptotic role of endogenous nitric oxide in human melanoma cells.

2001 • 99 citations

Dead or alive: immunogenicity of human melanoma cells when presented by dendritic cells.

2000 • 85 citations

Fibronectin Suppresses Apoptosis in Normal Human Melanocytes Through an Integrin-Dependent Mechanism

1997 • 82 citations

Differential Loss of T Cell Signaling Molecules in Metastatic Melanoma Patients’ T Lymphocyte Subsets Expressing Distinct TCR Variable Regions

1999 • 45 citations

Cycling of human dendritic cell effector phenotypes in response to TNF‐α: modification of the current ‘maturation’ paradigm and implications forin vivoimmunoregulation

1999 • 38 citations

T-cell memory: You must remember this…

2000 • 20 citations