Tumour suppressor genes in sporadic epithelial ovarian cancer

Identification of the breast cancer susceptibility gene BRCA2

1995 • 3,581 citations

Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families

1998 • 2,920 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Cancer-epigenetics comes of age

1999 • 2,379 citations

Multicolor Spectral Karyotyping of Human Chromosomes

1996 • 1,780 citations

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

1995 • 1,353 citations

Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome

1996 • 767 citations

p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3

1995 • 426 citations

Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors.

1998 • 423 citations

The gene for human p53 cellular tumor antigen is located on chromosome 17 short arm (17p13).

1986 • 371 citations

Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice.

1994 • 369 citations

BRCA2 mutations in primary breast and ovarian cancers

1996 • 365 citations

The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53

1998 • 357 citations

Genetic analysis of benign, low-grade, and high-grade ovarian tumors.

1995 • 299 citations

NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas

1999 • 298 citations

Allelotype of human ovarian cancer.

1991 • 257 citations

Frequent Loss of PTEN Expression Is Linked to Elevated Phosphorylated Akt Levels, but Not Associated with p27 and Cyclin D1 Expression, in Primary Epithelial Ovarian Carcinomas

2001 • 251 citations

Human epithelial ovarian cancer allelotype.

1993 • 241 citations

WWOX : A candidate tumor suppressor gene involved in multiple tumor types

2001 • 221 citations

CpG methylation within the 5′ regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site

1998 • 192 citations

Molecular Cloning of Differentially Expressed Genes in Human Epithelial Ovarian Cancer

1994 • 183 citations

Spontaneous Transformation of Rat Ovarian Surface Epithelial Cells: Association With Cytogenetic Changes and Implications of Repeated Ovulation in the Etiology of Ovarian Cancer

1992 • 182 citations

DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer

1998 • 182 citations

Frequent silencing of the GPC3 gene in ovarian cancer cell lines.

1999 • 173 citations

Allele loss from chromosome 17 in ovarian cancer.

1990 • 156 citations

Tumour-suppressor genes: evolving definitions in the genomic age

1997 • 148 citations

Identification of two candidate tumor suppressor genes on chromosome 17p13.3.

1996 • 146 citations

Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene

2000 • 120 citations

Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2

1998 • 119 citations

Allelic deletion on chromosome 17p13.3 in early ovarian cancer.

1996 • 112 citations

Definition and refinement of a region of loss of heterozygosity at 11q23.3-q24.3 in epithelial ovarian cancer associated with poor prognosis.

1996 • 108 citations

Isolation and mapping of a human septin gene to a region on chromosome 17q, commonly deleted in sporadic epithelial ovarian tumors.

2000 • 104 citations

Fine-scale deletion mapping of the distal long arm of chromosome 6 in 70 human ovarian cancers.

1992 • 103 citations

Comparison of Fluorescence-Based Semi-automated Genotyping of Multiple Microsatellite Loci with Autoradiographic Techniques

1994 • 102 citations

Genomic and Expression Analyses of Alternatively Spliced Transcripts of the MLL Septin-like Fusion Gene (MSF) That Map to a 17q25 Region of Loss in Breast and Ovarian Tumors

2000 • 94 citations

Allele loss on chromosome arm 6q and fine mapping of the region at 6q27 in epithelial ovarian cancer

1996 • 83 citations

Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours

1999 • 81 citations

Loss of heterozygosity on chromosome 13 is common only in the biologically more aggressive subtypes of ovarian epithelial tumors and is associated with normal retinoblastoma gene expression.

1994 • 77 citations

Refinement of two chromosome 11q regions of loss of heterozygosity in ovarian cancer.

1996 • 74 citations

Expression of OVCA1, a candidate tumor suppressor, is reduced in tumors and inhibits growth of ovarian cancer cells.

1999 • 63 citations

Definition of a commonly deleted region in ovarian cancers to a 300-kb segment of chromosome 6q27.

1996 • 62 citations

Catalog of chromosome aberrations in cancer (5th edn)

1995 • 62 citations

LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein

1999 • 61 citations

ARHI is the center of allelic deletion on chromosome 1p31 in ovarian and breast cancers

2000 • 58 citations

BARX2 induces cadherin 6 expression and is a functional suppressor of ovarian cancer progression.

2001 • 58 citations

Detailed genetic and physical mapping of tumor suppressor loci on chromosome 3p in ovarian cancer.

1999 • 54 citations

Loss of heterozygosity on chromosomes 7p, 7q, 9p and 11q is an early event in ovarian tumorigenesis

1998 • 52 citations

Loss of heterozygosity at chromosome segment Xq25-26.1 in advanced human ovarian carcinomas

1997 • 49 citations

Analysis of loss of heterozygosity andKRAS2 mutations in ovarian neoplasms: Clinicopathological correlations

1997 • 48 citations

Suppression of tumorigenicity in human ovarian cancer cell lines is controlled by a 2 cM fragment in chromosomal region 6q24-q25

1999 • 48 citations

A 400 kb novel deletion unit centromeric to the BRCA1 gene in sporadic epithelial ovarian cancer.

1996 • 48 citations

Antioncogenes and Human Cancer

1993 • 45 citations

A novel 4-cM minimally deleted region on chromosome 11p15.1 associated with high grade nonmucinous epithelial ovarian carcinomas.

1997 • 45 citations

Chromosome 11q22.3-q25 LOH in Ovarian Cancer: Association with a More Aggressive Disease Course and Involved Subregions

1998 • 45 citations

Molecular mechanisms possibly affecting WT1 function in human ovarian tumors

1994 • 43 citations

A gene on 6q 14-21 restores senescence to immortal ovarian tumor cells.

1996 • 43 citations

ATM: the product of the gene mutated in ataxia-telangiectasia

1999 • 42 citations

Genes involved in hereditary nonpolyposis colorectal carcinoma.

1994 • 42 citations

Intraperitoneal gene therapy with adenoviral-mediated p53 tumor suppressor gene for ovarian cancer model in nude mouse

1999 • 41 citations

Frequent loss of heterozygosity at 1p36 in ovarian adenocarcinomas but the gene encoding p73 is unlikely to be the target

1999 • 40 citations

Allelic loss on chromosome 7q in ovarian adenocarcinomas: two critical regions and a rearrangement of the PLANH1 locus.

1996 • 39 citations

Loss of heterozygosity of chromosome 17 in human borderline and invasive epithelial ovarian tumors.

1996 • 38 citations

Loss of heterozygosity on chromosome 5 in sporadic ovarian carcinoma is a late event and is not associated with mutations in APC at 5q21-22

1994 • 36 citations

Ovarian Cancer: Loss of Heterozygosity Frequently Occurs in the ATM Gene, but Structural Alterations Do Not Occur in This Gene

1999 • 28 citations

Physical and transcript map of the region between D6S264 and D6S149 on chromosome 6q27, the minimal region of allele loss in sporadic epithelial ovarian cancer

2002 • 27 citations

Targeting Frequency for Deletion Vectors in Embryonic Stem Cells

1994 • 23 citations

Cloning of a novel phosphoprotein regulated by colony-stimulating factor 1 shares a domain with the Drosophila disabled gene product.

1996 • 19 citations

Analysis of Allelic Imbalance on Chromosome 17p13 in Stage I and Stage II Epithelial Ovarian Cancers

1998 • 18 citations

Differential expression of NF1 type I and type II isoforms in sporadic borderline and invasive epithelial ovarian tumors

1999 • 14 citations

Frequent loss of heterozygosity on chromosomes 7 and 9 in benign epithelial ovarian tumours

1997 • 12 citations

Mutation analysis of RASK and the ‘FLR exon’ of NF1 in sporadic ovarian carcinoma

1994 • 9 citations

Molecular approaches to diagnosis and management of ovarian cancer

1997 • 3 citations