Molecular mechanisms possibly affecting WT1 function in human ovarian tumors

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

1990 • 1,882 citations

A Comparative Study of the Peroxidase-antiperoxidase Method and an Avidin-Biotin Complex Method for Studying Polypeptide Hormones with Radioimmunoassay Antibodies

1981 • 1,664 citations

Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome

1991 • 944 citations

The candidate Wilms' tumour gene is involved in genitourinary development

1990 • 884 citations

An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor

1990 • 577 citations

Repression of the Insulin-Like Growth Factor II Gene by the Wilms Tumor Suppressor WT1

1992 • 535 citations

[103a] The use of guanidinium chloride in the isolation of nucleic acids

1968 • 494 citations

Transcriptional Repression Mediated by the WT1 Wilms Tumor Gene Product

1991 • 492 citations

WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour

1991 • 471 citations

Expression of the Wilms' tumor gene WT1 in the murine urogenital system.

1991 • 447 citations

Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3' untranslated regions are isotype specific but are conserved in evolution.

1983 • 393 citations

Expression of the Wilms' tumor gene (WT1) in human leukemias.

1992 • 354 citations

Physical and functional interaction between WT1 and p53 proteins.

1993 • 308 citations

p53 gene mutations and protein accumulation in human ovarian cancer.

1993 • 294 citations

Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product.

1993 • 268 citations

Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1.

1992 • 226 citations

The Wilms' tumor gene product WT1 activates or suppresses transcription through separate functional domains

1993 • 198 citations

The genomic organization and expression of the WT1 gene

1992 • 140 citations

p53 abnormalities in different subtypes of human sarcomas.

1993 • 139 citations

Homozygous somatic Wt1 point mutations in sporadic unilateral Wilms tumor.

1993 • 79 citations

Structural rearrangements of the WT1 gene in Wilms' tumour cells.

1991 • 69 citations

Inactivation of the remaining allele of the WT1 gene in a Wilms' tumour from a WAGR patient.

1992 • 60 citations

Chromosomal localisation of two putative 11p oncosuppressor genes involved in human ovarian tumours

1992 • 53 citations

Characterization of the transcriptional regulatory region of the human WT1 gene.

1993 • 51 citations

Smallest region of overlap in Wilms tumor deletions uniquely implicates an 11p13 zinc finger gene as the disease locus

1991 • 50 citations

RNA Expression of the WT1 Gene in Wilms' Tumors in Relation to Histology

1992 • 41 citations

Altered trans-activational properties of a mutated WT1 gene product in a WAGR-associated Wilms' tumor.

1993 • 36 citations

Deletion of chromosome 11p13-11p15.5 sequences in invasive human ovarian cancer is a subclonal progression factor.

1992 • 30 citations

Genomic changes in the WT-gene (WT1) in Wilms' tumors and their correlation with histology.

1992 • 20 citations

Hinfl polymorphism within the 3′ untranslated region of the candidate Wilms tumour gene

1991 • 19 citations

c-myc Overexpression is a tumor-specific phenomenon in a subset of human colorectal carcinomas

1990 • 19 citations

Genomic Organization of the Human WT1 Gene

1992 • 17 citations

Loss of heterozygosity at 11p13 in Wilms' tumours does not necessarily involve mutations in the WT1 gene

1993 • 14 citations

A single base pair polymorphism in the WT1 gene detected by single-strand conformation polymorphism analysis

1992 • 12 citations

Taql RFLPs at the Wilms' tumor gene (WT1)

1991 • 4 citations