Perlecan inhibits smooth muscle cell adhesion to fibronectin: Role of heparan sulfate

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Atherosclerosis

2000 • 4,558 citations

Cell Biology of Atherosclerosis

1995 • 982 citations

Suppression by heparin of smooth muscle cell proliferation in injured arteries

1977 • 798 citations

Isolation of a heparan sulfate-containing proteoglycan from basement membrane.

1980 • 672 citations

Perlecan Maintains the Integrity of Cartilage and Some Basement Membranes

1999 • 665 citations

Macromolecular organization of basement membranes

1996 • 661 citations

The complete sequence of perlecan, a basement membrane heparan sulfate proteoglycan, reveals extensive similarity with laminin A chain, low density lipoprotein-receptor, and the neural cell adhesion molecule.

1991 • 446 citations

Adhesion and cytoskeletal organisation of fibroblasts in response to fibronectin fragments.

1986 • 429 citations

Osteopontin promotes vascular cell adhesion and spreading and is chemotactic for smooth muscle cells in vitro.

1994 • 392 citations

Diverse effects of fibronectin and laminin on phenotypic properties of cultured arterial smooth muscle cells.

1988 • 384 citations

Inhibition of rat arterial smooth muscle cell proliferation by heparin. II. In vitro studies.

1980 • 337 citations

Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor.

1992 • 307 citations

Defining the Interleukin-8-binding Domain of Heparan Sulfate

1998 • 259 citations

A synthetic peptide from the COOH-terminal heparin-binding domain of fibronectin promotes focal adhesion formation.

1993 • 202 citations

Phenotypic Modulation of Smooth Muscle Cells after Arterial Injury Is Associated with Changes in the Distribution of Laminin and Fibronectin

1997 • 182 citations

Endothelial cells interact with the core protein of basement membrane perlecan through beta 1 and beta 3 integrins: an adhesion modulated by glycosaminoglycan.

1992 • 180 citations

Inhibition of smooth muscle cell proliferation in injured rat arteries. Interaction of heparin with basic fibroblast growth factor.

1992 • 159 citations

Perlecan is a component of cartilage matrix and promotes chondrocyte attachment

1995 • 151 citations

The Protein Core of the Proteoglycan Perlecan Binds Specifically to Fibroblast Growth Factor-7

2000 • 143 citations

Conformational Transitions in the Cell Binding Domain of Fibronectin

1995 • 136 citations

Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells

1999 • 136 citations

A substrate of the cell-attachment sequence of fibronectin (Arg-Gly-Asp-Ser) is sufficient to promote transition of arterial smooth muscle cells from a contractile to a synthetic phenotype

1989 • 110 citations

Endothelial Heparan Sulfate Proteoglycan. I. Inhibitory Effects on Smooth Muscle Cell Proliferation

1990 • 89 citations

A role for perlecan in the suppression of growth and invasion in fibrosarcoma cells.

1997 • 85 citations

Arterial heparan sulfate proteoglycans inhibit vascular smooth muscle cell proliferation and phenotype change in vitro and neointimal formation in vivo

1998 • 75 citations

Vascular smooth muscle cells grown on Matrigel. A model of the contractile phenotype with decreased activation of mitogen-activated protein kinase.

1994 • 75 citations

Perlecan in human bone marrow: A growth-factor-presenting, but anti-adhesive, extracellular matrix component for hematopoietic cells

1995 • 69 citations

Control of Smooth Muscle Cell Proliferation – The Role of the Basement Membrane

1999 • 62 citations

Diverse Effects of Heparin on Mitogen-Activated Protein Kinase–Dependent Signal Transduction in Vascular Smooth Muscle Cells

1997 • 60 citations

Perlecan regulates Oct-1 gene expression in vascular smooth muscle cells.

1997 • 39 citations

Disruption of integrin α5β1 signaling does not impair PDGF-BB-mediated stimulation of the extracellular signal-regulated kinase pathway in smooth muscle cells

1997 • 29 citations

Interaction of skeletal muscle cells with collagen type IV is mediated by perlecan associated with the cell surface

1999 • 23 citations

Glomerular basement membrane-derived perlecan inhibits mesangial cell adhesion to fibronectin.

1996 • 22 citations

Novel Purification and Detailed Characterization of Perlecan Isolated from the Engelbreth-Holm-Swarm Tumor for Use in an Animal Model of Fibrillar A Amyloid Persistence in Brain

1996 • 21 citations

Attachment Substrates for Smooth Muscle Cells

1990 • 20 citations

Deleted Work

1955 • 0 citations