Elevated Expression of Ets2 or Distinct Portions of Ets2 Can Reverse Ras-mediated Cellular Transformation

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

Transforming p21 Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions

1995 • 803 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

The activities of two Ets-related transcription factors required for drosophila eye development are modulated by the Ras/MAPK pathway

1994 • 690 citations

Altered Growth of Human Colon Cancer Cell Lines Disrupted at Activated Ki- ras

1993 • 627 citations

High-Intensity Raf Signal Causes Cell Cycle Arrest Mediated by p21^Cip1

1997 • 464 citations

The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins.

1991 • 380 citations

The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells

1993 • 330 citations

Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway

1995 • 327 citations

Ras-Mediated Phosphorylation of a Conserved Threonine Residue Enhances the Transactivation Activities of c-Ets1 and c-Ets2

1996 • 325 citations

The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway

1994 • 315 citations

MafB Is an Interaction Partner and Repressor of Ets-1 That Inhibits Erythroid Differentiation

1996 • 291 citations

Bicistronic Vector for the Creation of Stable Mammalian Cell Lines that Predisposes All Antibiotic-Resistant Cells to Express Recombinant Protein

1996 • 288 citations

Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL

1997 • 266 citations

Mammalian ets-1 and ets-2 genes encode highly conserved proteins.

1988 • 248 citations

The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ formation.

1993 • 228 citations

Flat revertants isolated from Kirsten sarcoma virus-transformed cells are resistant to the action of specific oncogenes.

1983 • 221 citations

Net, a new ets transcription factor that is activated by Ras.

1994 • 216 citations

[40] Biological assays for Ras transformation

1995 • 199 citations

PEA3 is a nuclear target for transcription activation by non-nuclear oncogenes.

1989 • 197 citations

Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes.

1995 • 195 citations

Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases.

1994 • 185 citations

A direct physical association between ETS and AP-1 transcription factors in normal human T cells

1995 • 184 citations

ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation.

1995 • 163 citations

Rapid Phosphorylation of Ets-2 Accompanies Mitogen-Activated Protein Kinase Activation and the Induction of Heparin-Binding Epidermal Growth Factor Gene Expression by Oncogenic Raf-1

1997 • 162 citations

Mitogenic Signaling By Colony-Stimulating Factor 1 and ras Is Suppressed by the ets-2 DNA-Binding Domain and Restored by myc Overexpression

1992 • 147 citations

The activity of the Ets transcription factor PEA3 is regulated by two distinct MAPK cascades.

1996 • 143 citations

The prokaryotic neomycin-resistance-encoding gene acts as a transcriptional silencer in eukaryotic cells

1991 • 139 citations

Oncogenic Neu/ErbB-2 Increases Ets, AP-1, and NF-kB-dependent Gene Expression, and Inhibiting Ets Activation Blocks Neu-mediated Cellular Transformation

1996 • 127 citations

The c-ets-1 proto-oncogene has oncogenic activity and is positively autoregulated.

1990 • 126 citations

Identification in chickens of an evolutionarily conserved cellular ets-2 gene (c-ets-2) encoding nuclear proteins related to the products of the c-ets proto-oncogene.

1988 • 122 citations

Oncogenic Ras can induce transcriptional activation through a variety of promoter elements, including tandem c-Ets-2 binding sites.

1994 • 122 citations

Analysis of the ERK-Stimulated ETS Transcription Factor ER81

1996 • 121 citations

The Ets Transcription Factors Interact with Each Other and with the c-Fos/c-Jun Complex via Distinct Protein Domains in a DNA-dependent and -independent Manner

1997 • 117 citations

The ETS-related transcription factor ERM is a nuclear target of signaling cascades involving MAPK and PKA.

1996 • 82 citations

Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF

1992 • 79 citations

c-ets-2 protooncogene has mitogenic and oncogenic activity.

1989 • 79 citations

Reversion of Ras transformed cells by Ets transdominant mutants.

1994 • 69 citations

Identification of differentially expressed prostate genes: Increased expression of transcription factor ETS-2 in prostate cancer

1997 • 60 citations

ETS1 and ETS2 in p53 regulation: spatial separation of ETS binding sites (EBS) modulate protein: DNA interaction.

1996 • 59 citations

A Regulatory Element within a Coding Exon Modulates Keratin 18 Gene Expression in Transgenic Mice

1997 • 56 citations

cis regulation of the keratin 18 gene in transgenic mice.

1993 • 55 citations

[25] Immune complex kinase assays for mitogen-activated protein kinase and MEK

1995 • 53 citations

[41] Ras-mediated transcription activation: Analysis by transient cotransfection assays

1995 • 51 citations

The retinoblastoma binding factor 1 (RBF-1) site in RB gene promoter binds preferentially E4TF1, a member of the Ets transcription factors family.

1994 • 42 citations

ETS1 suppresses tumorigenicity of human colon cancer cells.

1995 • 42 citations

Activation of the p21Waf1/Cip1Promoter by theetsOncogene Family Transcription Factor E1AF

1997 • 36 citations

Inhibition of oncogene-mediated transformation by ectopic expression of p21Waf1 in NIH3T3 cells.

1996 • 32 citations

Net-b, a Ras-Insensitive Factor That Forms Ternary Complexes with Serum Response Factor on the Serum Response Element of the fos Promoter

1997 • 27 citations

[23] Transcriptional activation analysis of oncogene function

1994 • 13 citations

Human retinoblastoma gene product prevents c-Ha-ras oncogene mediated cellular transformation of mouse fibroblasts.

1993 • 7 citations