NKX3.1 Is Regulated by Protein Kinase CK2 in Prostate Tumor Cells

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Cancer Statistics, 2003

2003 • 3,302 citations

Protein kinase CK2: structure, regulation and role in cellular decisions of life and death

2002 • 1,202 citations

Molecular genetics of prostate cancer

2000 • 723 citations

Roles for Nkx3.1 in prostate development and cancer

1999 • 660 citations

THE ENZYMATIC PHOSPHORYLATION OF PROTEINS

1954 • 537 citations

Protein kinase CK2: a challenge to canons

2002 • 470 citations

Reduced Ubiquitin-Dependent Degradation of c-Jun After Phosphorylation by MAP Kinases

1997 • 462 citations

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

1998 • 445 citations

Protein kinase CK2 and its role in cellular proliferation, development and pathology

1999 • 388 citations

Joining the cell survival squad: an emerging role for protein kinase CK2

2002 • 384 citations

Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression.

2000 • 377 citations

A Novel Human Prostate-Specific, Androgen-Regulated Homeobox Gene (NKX3.1) That Maps to 8p21, a Region Frequently Deleted in Prostate Cancer

1997 • 363 citations

Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis

2002 • 320 citations

Allelic loss on chromosome 8p12-21 in microdissected prostatic intraepithelial neoplasia.

1995 • 289 citations

PhosphoBase, a database of phosphorylation sites: release 2.0

1999 • 287 citations

Deletion mapping of chromosomes 8, 10, and 16 in human prostatic carcinoma

1991 • 286 citations

Analysis of 99 microdissected prostate carcinomas reveals a high frequency of allelic loss on chromosome 8p12-21.

1996 • 254 citations

Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis.

2002 • 242 citations

Prostate-specific and Androgen-dependent Expression of a Novel Homeobox Gene

1996 • 238 citations

Conditional Loss of Nkx3.1 in Adult Mice Induces Prostatic Intraepithelial Neoplasia

2002 • 235 citations

Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases.

2003 • 229 citations

Haploinsufficiency for tumour suppressor genes: when you don't need to go all the way

2004 • 213 citations

Chromosomal deletions and tumor suppressor genes in prostate cancer.

2001 • 191 citations

Tissue-specific expression of murineNkx3.1 in the male urogenital system

1997 • 178 citations

Suppression of α-Cyano-4-hydroxycinnamic Acid Matrix Clusters and Reduction of Chemical Noise in MALDI-TOF Mass Spectrometry

2004 • 170 citations

CK2 Phosphorylation of the Armadillo Repeat Region of β-Catenin Potentiates Wnt Signaling

2003 • 165 citations

Functional interaction of protein kinase CK2 and c-Myc in lymphomagenesis

2002 • 150 citations

Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers.

1997 • 148 citations

Haploinsufficiency at the Nkx3.1 locus

2003 • 142 citations

A Matter of Dosage

2002 • 130 citations

Isolation and androgen regulation of the human homeobox cDNA,NKX3.1

1998 • 129 citations

A critical role for p27 ^kip1 gene dosage in a mouse model of prostate carcinogenesis

2004 • 122 citations

A role for phosphorylation by casein kinase II in modulating Antennapedia activity in Drosophila.

1997 • 119 citations

Nuclear casein kinase 2 (CK‐2) activity in human normal, benign hyperplastic, and cancerous prostate

1994 • 119 citations

Cell Cycle-regulated Phosphorylation of the Human SIX1 Homeodomain Protein

2000 • 113 citations

Haplo-insufficiency? Let me count the ways: Figure 1.

2001 • 111 citations

Targeted disruption of the Nkx3.1 gene in mice results in morphogenetic defects of minor salivary glands: parallels to glandular duct morphogenesis in prostate

2000 • 109 citations

Accommodating haploinsufficient tumour suppressor genes in Knudson's model

2000 • 109 citations

EXPRESSION PROFILE OF AN ANDROGEN REGULATED PROSTATE SPECIFIC HOMEOBOX GENE NKX3.1 IN PRIMARY PROSTATE CANCER

2000 • 99 citations

Nkx3.1, a murine homolog of Drosophila bagpipe, regulates epithelial ductal branching and proliferation of the prostate and palatine glands

2000 • 98 citations

Roles of the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis

2003 • 98 citations

NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter.

2002 • 97 citations

CK2 Inhibits Apoptosis and Changes Its Cellular Localization Following Ionizing Radiation

2005 • 94 citations

Identification of the In Vivo Casein Kinase II Phosphorylation Site within the Homeodomain of the Cardiac Tisue-Specifying Homeobox Gene Product Csx/Nkx2.5

1999 • 90 citations

Enhanced Ionization of Phosphorylated Peptides during MALDI TOF Mass Spectrometry

2004 • 85 citations

EXPRESSION STUDIES AND MUTATIONAL ANALYSIS OF THE ANDROGEN REGULATED HOMEOBOX GENE NKX3.1 IN BENIGN AND MALIGNANT PROSTATE EPITHELIUM

2001 • 84 citations

Allelic loss of 8p sequences in prostatic intraepithelial neoplasia and carcinoma

1997 • 76 citations

Deficiency of Retinoblastoma gene in mouse embryonic stem cells leads to genetic instability.

2002 • 70 citations

DNA Binding by Cut Homeodomain Proteins Is Down-modulated by Protein Kinase C

1996 • 67 citations

Phosphorylation of the Drosophila Engrailed Protein at a Site Outside Its Homeodomain Enhances DNA Binding

1995 • 64 citations

Promiscuous subunit interactions: A possible mechanism for the regulation of protein kinase CK2

1998 • 62 citations

Determination of a minimal deletion interval on chromosome band 8p21 in sporadic prostate cancer†

2001 • 62 citations

DNA Binding by Cut Homeodomain Proteins Is Down-modulated by Casein Kinase II

1998 • 51 citations

Improvement in the detection of low concentration protein digests on a MALDI TOF/TOF workstation by reducing alpha-cyano-4-hydroxycinnamic acid adduct ions.

2003 • 47 citations

ANALYSIS OF ANDROGEN REGULATED HOMEOBOX GENE NKX3.1 DURING PROSTATE CARCINOGENESIS

2004 • 44 citations

Occurrence of NKX3.1 C154T polymorphism in men with and without prostate cancer and studies of its effect on protein function.

2002 • 43 citations

Structural Features Underlying the Unusual Mode of Calmodulin Phosphorylation by Protein Kinase CK2: A Study with Synthetic Calmodulin Fragments

1999 • 33 citations

In-Gel Kinase Assay as a Method to Identify Kinase Substrates

2002 • 32 citations

Double transfection improves small interfering RNA‐induced thrombin receptor (PAR‐1) gene silencing in DU 145 prostate cancer cells

2004 • 32 citations

Improved siRNA-mediated silencing in refractory adherent cell lines by detachment and transfection in suspension

2004 • 30 citations

Structural and functional analysis of domains mediating interaction between NKX‐3.1 and PDEF

2004 • 27 citations

Allosteric Regulation of Even-skipped Repression Activity by Phosphorylation

1999 • 23 citations