The Serotonergic System and Anxiety

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

2013 • 8,227 citations

Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region

1996 • 5,154 citations

Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

2003 • 4,175 citations

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

2013 • 3,921 citations

Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus

2000 • 3,047 citations

The Neuropsychology of Anxiety

2003 • 1,928 citations

Molecular, pharmacological and functional diversity of 5-HT receptors

2002 • 1,822 citations

Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA

1995 • 1,211 citations

Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult

2002 • 901 citations

A simple and reliable conflict procedure for testing anti-anxiety agents

1971 • 832 citations

Serotonin receptor 1A knockout: An animal model of anxiety-related disorder

1998 • 802 citations

Altered Brain Serotonin Homeostasis and Locomotor Insensitivity to 3,4-Methylenedioxymethamphetamine (“Ecstasy”) in Serotonin Transporter-Deficient Mice

1998 • 704 citations

Elevated anxiety and antidepressant-like responses in serotonin 5-HT _1A receptor mutant mice

1998 • 690 citations

The Structure of the Genetic and Environmental Risk Factors for Six Major Psychiatric Disorders in Women

1995 • 684 citations

Increased anxiety of mice lacking the serotonin _1A receptor

1998 • 684 citations

A Serotonin Transporter Gene Promoter Polymorphism (5-HTTLPR) and Prefrontal Cortical Binding in Major Depression and Suicide

2000 • 603 citations

Excess of High Activity Monoamine Oxidase A Gene Promoter Alleles in Female Patients with Panic Disorder

1999 • 592 citations

Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro.

1987 • 550 citations

Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets

1999 • 523 citations

Lack of Barrels in the Somatosensory Cortex of Monoamine Oxidase A–Deficient Mice: Role of a Serotonin Excess during the Critical Period

1996 • 513 citations

Antidepressants and neuroplasticity

2002 • 498 citations

5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: More than 30 years of research

1995 • 497 citations

Pet-1 ETS Gene Plays a Critical Role in 5-HT Neuron Development and Is Required for Normal Anxiety-like and Aggressive Behavior

2003 • 453 citations

The effects of chronic antidepressant treatment in an animal model of anxiety

1988 • 406 citations

Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice

2003 • 387 citations

Finding the Intracellular Signaling Pathways Affected by Mood Disorder Treatments

2003 • 362 citations

Functional characterization of agonists at recombinant human 5‐HT_2A, 5‐HT_2B and 5‐HT_2C receptors in CHO‐K1 cells

1999 • 347 citations

Benzodiazepines: Anxiety-Reducing Activity by Reduction of Serotonin Turnover in the Brain

1972 • 339 citations

Serotonin and Hippocampal Neurogenesis

1999 • 331 citations

The ETS Domain Factor Pet-1 Is an Early and Precise Marker of Central Serotonin Neurons and Interacts with a Conserved Element in Serotonergic Genes

1999 • 302 citations

Tryptophan depletion and its implications for psychiatry

2001 • 278 citations

Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine measured in vivo.

1995 • 278 citations

Altered expression and functions of serotonin 5‐HT_1A and 5‐HT_1B receptors in knock‐out mice lacking the 5‐HT transporter

2000 • 271 citations

Excessive Activation of Serotonin (5-HT) 1B Receptors Disrupts the Formation of Sensory Maps in Monoamine Oxidase A and 5-HT Transporter Knock-Out Mice

2001 • 267 citations

The elevated T-maze: A new animal model of anxiety and memory

1994 • 265 citations

Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis

1994 • 261 citations

Reduced aggression in mice lacking the serotonin transporter

2002 • 247 citations

Chronic treatment with fluvoxamine increases extracellular serotonin in frontal cortex but not in raphe nuclei

1993 • 239 citations

Serotonin facilitates GABAergic transmission in the CA1 region of rat hippocampus in vitro.

1991 • 231 citations

Comparative Study of Pre- and Postsynaptic 5-HT_1AReceptor Modulation of Anxiety in Two Ethological Animal Tests

1996 • 229 citations

5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus

2002 • 229 citations

A comparison of the effects of diazepam versus several typical and atypical anti-depressant drugs in an animal model of anxiety

1989 • 222 citations

Association between serotonin transporter gene polymorphism and anxiety-related traits

1999 • 201 citations

Dual role of 5-HT in defense and anxiety

1997 • 199 citations

Refinement of Thalamocortical Arbors and Emergence of Barrel Domains in the Primary Somatosensory Cortex: A Study of Normal and Monoamine Oxidase A Knock-Out Mice

2002 • 184 citations

Genetic inactivation of the Serotonin(1A) receptor in mice results in downregulation of major GABA(A) receptor alpha subunits, reduction of GABA(A) receptor binding, and benzodiazepine-resistant anxiety.

2000 • 184 citations

Effects of 5‐HT uptake inhibitors, agonists and antagonists on the burying of harmless objects by mice; a putative test for anxiolytic agents

1991 • 179 citations

5-HT1A receptor knockout mouse as a genetic model of anxiety

2003 • 170 citations

Acute and Chronic Effects of Gepirone and Fluoxetine in Rats Tested in the Elevated Plus-maze

2000 • 169 citations

Interaction of arylpiperazines with 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors: do discriminatory 5-HT1B receptor ligands exist?

1989 • 168 citations

Modifications of the serotonergic system in mice lacking serotonin transporters: an in vivo electrophysiological study.

2001 • 162 citations

5-Hydroxytryptamine4-like receptors mediate the slow excitatory response to serotonin in the rat hippocampus.

1991 • 162 citations

Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice

1997 • 149 citations

The Vogel conflict test: procedural aspects, γ-aminobutyric acid, glutamate and monoamines

2003 • 146 citations

The serotonin hypothesis of obsessive compulsive disorder: implications of pharmacologic challenge studies.

1992 • 145 citations

A Database of [11C]WAY-100635 Binding to 5-HT1A Receptors in Normal Male Volunteers: Normative Data and Relationship to Methodological, Demographic, Physiological, and Behavioral Variables

2002 • 145 citations

An association study of a functional polymorphism of the serotonin transporter gene with personality and psychiatric symptoms

1998 • 136 citations

Brain region‐specific alterations of 5‐HT_2A and 5‐HT_2C receptors in serotonin transporter knockout mice

2003 • 135 citations

Tryptophan Depletion in Patients With Obsessive-Compulsive Disorder Who Respond to Serotonin Reuptake Inhibitors

1994 • 133 citations

Inverse Relationship Between Serotonin 5-HT_1A Receptor Binding and Anxiety: A [¹¹C]WAY-100635 PET Investigation in Healthy Volunteers

2001 • 133 citations

Role of 5-HT receptor subtypes in the modulation of dorsal periaqueductal gray generated aversion

1995 • 132 citations

Acute and chronic treatment with 5-HT reuptake inhibitors differentially modulate emotional responses in anxiety models in rodents

1994 • 129 citations

5-Hydroxytryptamine2 receptor facilitates GABAergic neurotransmission in rat hippocampus.

1998 • 124 citations

Intra-hippocampal buspirone in animal models of anxiety

1989 • 124 citations

Anxiolytic effects in the plus-maze of 5-HT1A-receptor ligands in dorsal raphé and ventral hippocampus

1996 • 120 citations

Serotonin reuptake inhibitors reduce conditioned fear stress-induced freezing behavior in rats

1996 • 119 citations

Association between obsessive-compulsive disorder and polymorphisms of genes encoding components of the serotonergic and dopaminergic pathways

2000 • 118 citations

Attenuation of chemically induced defence response by 5-HT1 receptor agonists administered into the periaqueductal gray

1992 • 102 citations

Anxiogenic-like effect of infusing 1-(3-chlorophenyl) piperazine (mCPP) into the hippocampus

1990 • 96 citations

Effect of acute tryptophan depletion on CO₂-induced anxiety in patients with panic disorder and normal volunteers

2000 • 94 citations

Altered regulation of the 5‐HT system in the brain of MAO‐A knock‐out mice

2002 • 93 citations

The Effects of Sertraline and Fluoxetine on Anxiety in the Elevated Plus-Maze Test

2000 • 91 citations

Effects of tryptophan depletion on anxiety and on panic provoked by carbon dioxide challenge

1998 • 91 citations

Ketanserin and tetrabenazine abolish aggression in mice lacking monoamine oxidase A

1999 • 91 citations

5-HT1A receptor knockout mice and mice overexpressing corticotropin-releasing hormone in models of anxiety

2003 • 90 citations

Serotonergic innervation of the hippocampus and nucleus accumbens septi and the anxiolytic-like action of midazolam and 5-HT1A a receptor agonists

1993 • 88 citations

Electrophysiological evidence for excitatory 5-HT2 and depressant 5-HT1A receptors on neurones of the rat midbrain tectum

1991 • 85 citations

Regulation of Membrane Excitability in the Central Nervous System by Serotonin Receptor Subtypes^a

1998 • 84 citations

Response to meta-chlorophenylpiperazine in panic disorder patients and healthy subjects: Influence of reduction in intravenous dosage

1994 • 79 citations

Stimulation of hippocampal 5-HT1A receptors causes amnesia and anxiolytic-like but not antidepressant-like effects in the rat

1993 • 73 citations

Serotonergic and catecholaminergic reuptake inhibitors have opposite effects on the ultrasonic isolation calls of rat pups.

1990 • 73 citations

No association between serotonin transporter gene polymorphisms and personality traits

1999 • 70 citations

Lack of genetic linkage or association between a functional serotonin transporter polymorphism and panic disorder

1999 • 69 citations

The effect of central and systemic injection of the 5-HT1A receptor agonist 8-OHDPAT and the 5-HT1A receptor antagonist WAY100635 on periaqueductal grey-induced defence behaviour

1997 • 66 citations

Effect of citalopram, a selective serotonin reuptake inhibitor, on the acquisition of conditioned freezing

1996 • 66 citations

Acute l-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients

2002 • 61 citations

Effects of intra-hippocampal infusion of WAY-100635 on plus-maze behavior in mice

2002 • 56 citations

The Neurobiology of Anxiety Disorders

1995 • 56 citations

Effects of genetic depletion of monoamines on somatosensory cortical development

2002 • 51 citations

Serotonergic function in social phobia: comparison to normal control and obsessive–compulsive disorder subjects

1998 • 49 citations

The serotonin agonist m-chlorophenylpiperazine (mCPP) binds to serotonin transporter sites in human brain

1995 • 48 citations

No Association between the Serotonin Transporter-Linked Promoter Region Polymorphism and Either Schizophrenia or Density of the Serotonin Transporter in Human Hippocampus

1998 • 47 citations

Effects of tryptophan depletion on responses to yohimbine in healthy human subjects

1995 • 46 citations

Conflict situation increases serotonin release in rat dorsal hippocampus: in vivo study with microdialysis and Vogel test

1996 • 46 citations

Molecular foundation of anxiety disorders

2001 • 45 citations

Tryptophan depletion in obsessive-compulsive patients

1996 • 42 citations

GABAA–benzodiazepine receptor complex sensitivity in 5-HT1A receptor knockout mice on a 129/Sv background

2002 • 35 citations

New developments in the neurobiological basis of anxiety disorders.

2002 • 27 citations

Adaptive Changes in Postsynaptic Dopamine Receptors Despite Unaltered Dopamine Dynamics in Mice Lacking Monoamine Oxidase B

1999 • 27 citations

Modulation of the Extracellular 5-Hydroxytryptamine Brain Concentrations by the Serotonin and Noradrenaline Reuptake Inhibitor, Milnacipran Microdialysis Studies in Rats

1999 • 26 citations

The role of postsynaptic 5-HT1A receptors in the anticonflict effect of ipsapirone

1994 • 26 citations

Differential regulation of adenosine A1 and A2A receptors in serotonin transporter and monoamine oxidase A-deficient mice

2000 • 21 citations

Mutational Analysis of the Serotonergic System: Recent Findings Using Knockout Mice

2002 • 20 citations

Serotonin depolarizes hippocampal interneurones in the rat stratum oriens by interaction with 5HT2 receptors

1999 • 18 citations

Anticonflict effects of acute and chronic treatments with buspirone and gepirone in rats

1995 • 12 citations