Acute and chronic treatment with 5-HT reuptake inhibitors differentially modulate emotional responses in anxiety models in rodents

Neuropsychopharmacology

1990 • 1,545 citations

Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat

1986 • 1,509 citations

The effects of chronic antidepressant treatment in an animal model of anxiety

1988 • 406 citations

Obsessive-compulsive disorder and serotonin: Is there a connection?

1985 • 347 citations

Citalopram's ability to increase the extracellular concentrations of serotonin in the dorsal raphe prevents the drug's effect in the frontal cortex

1992 • 275 citations

Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat.

1991 • 251 citations

Differential effects of clomipramine given locally or systemically on extracellular 5-hydroxytryptamine in raphe nuclei and frontal cortex

1991 • 222 citations

A comparison of the effects of diazepam versus several typical and atypical anti-depressant drugs in an animal model of anxiety

1989 • 222 citations

An open trial of fluoxetine in the treatment of panic attacks.

1987 • 200 citations

5-Ht1a Agonists, 5-Ht3 Antagonists and Benzodiazepines: Their Comparative Behavioural Pharmacology

1991 • 194 citations

Neurochemical characterization of a new potent and selective serotonin uptake inhibitor: Lu 10-171

1977 • 174 citations

An Open Trial of Fluoxetine in the Treatment of Panic Attacks

1987 • 172 citations

Anxiogenic effects of methyl-β-carboline-3-carboxylate in a light/dark choice situation

1987 • 169 citations

Selective agonists and antagonists for 5-hydroxytryptamine receptor subtypes, and interactions with yohimbine and FG 7142 using the elevated plus-maze test in the rat

1987 • 156 citations

Animal Models for Predicting Clinical Efficacy of Anxiolytic Drugs: Social Behaviour

1985 • 142 citations

Interaction between effects of caffeine and lorazepam in performance tests and self-ratings.

1982 • 104 citations

Therapeutic effects of serotonin uptake inhibitors in depression.

1986 • 93 citations

Anxiolytic and anxiogenic drug effects in a novel test of anxiety: are exploratory models of anxiety in rodents valid?

1986 • 89 citations

Behavioral differences in an elevated plus-maze: correlation between anxiety and decreased number of GABA and benzodiazepine receptors in mouse cerebral cortex

1988 • 79 citations

Effects of sertraline and citalopram given repeatedly on the responsiveness of 5-HT receptor subpopulations

1992 • 72 citations

AMINE UPTAKE INHIBITORS: CRITERIA OF SELECTIVITY

1980 • 67 citations

Effects of acute and chronic anti-panic drug administration on conflict behavior in the rat

1989 • 62 citations

Classification and determination of cerebral bioavailability of fluoxetine: pharmacokinetic, pharmaco-EEG, and psychometric analyses.

1985 • 58 citations

Interactions of serotonin with ethanol: clinical and animal studies.

1987 • 44 citations

Anxiolytic-like effects of a selective 5-HT1A agonist, S20244, and its enantiomers in mice

1992 • 38 citations

m-Chlorophenylpiperazine enhances neophobic and anxious behaviour in mice

1991 • 38 citations

Ro 11-2465 (cyan-imipramine), citalopram and their N-desmethyl metabolites: Effects on the uptake of 5-hydroxytryptamine and noradrenaline in vivo and related pharmacological activities

1985 • 29 citations

5-HT uptake inhibitors: psychopharmacological and neurobiochemical criteria of selectivity.

1982 • 27 citations

Serenics fluprazine (DU 27716) and eltoprazine (DU 28853) enhance neophobic and emotional behaviour in mice

1990 • 26 citations

Clinical and Biochemical Effects of Selective Serotonin-Uptake Inhibitors in Anxiety Disorders

2015 • 16 citations

Serotonin Disturbances in Psychiatric Disorders: Functional versus Nosological Interpretation

2015 • 15 citations

Clinical significance of 5-HT uptake inhibitors

1991 • 14 citations

Some neuropharmacological effects of Ro 11-2465--a novel tricyclic antidepressant with potent inhibitory activity on the uptake of 5-HT.

1982 • 9 citations

Is Ro 11-2465 (Cyan-imipramine) an antagonist of postsynaptic serotonin receptors?

1981 • 7 citations

Serotonin in Anxiety and Related Disorders

1993 • 6 citations