Prediction of rodent nongenotoxic carcinogenesis: evaluation of biochemical and tissue changes in rodents following exposure to nine nongenotoxic NTP carcinogens.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP

1991 • 675 citations

Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats.

1988 • 357 citations

Mechanistically-based Human Hazard Assessment of Peroxisome Proliferator-induced Hepatocarcinogenesis

1994 • 318 citations

Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models.

1995 • 261 citations

Thyroid follicular cell carcinogenesis*1

1989 • 260 citations

Cytochromes P-450 in rats: structures, functions, properties and relevant human forms

1992 • 245 citations

Fatty acid oxidation by human liver peroxisomes

1979 • 197 citations

The effect of phenobarbital on the metabolism and excretion of thyroxine in rats

1989 • 189 citations

Hazard evaluation of chemicals that cause accumulation of alpha 2u-globulin, hyaline droplet nephropathy, and tubule neoplasia in the kidneys of male rats.

1993 • 147 citations

The impact of toxicity on carcinogenicity studies: implications for risk assessment

1988 • 134 citations

Mechanisms of Chemically Induced Renal Carcinogenesis in the Laboratory Rodent

1998 • 103 citations

Long‐Term Chemical Carcinogenesis Bioassays Predict Human Cancer Hazards: Issues, Controversies, and Uncertainties

1999 • 99 citations

Peroxisome Induction Studies On Seven Phthalate Esters

1987 • 98 citations

Comparative results of 327 chemical carcinogenicity studies.

1987 • 89 citations

Responses of Transgenic Mouse Lines p53+/- and TgAC to Agents Tested in Conventional Carcinogenicity Bioassays

2000 • 86 citations

Species Differences in Thyroid, Kidney and Urinary Bladder Carcinogenesis

1999 • 84 citations

A Comprehensive Approach for Integration of Toxicity and Cancer Risk Assessments

1999 • 81 citations

Effect of prolonged administration of clofibric acid and di-(2-ethylhexyl)phthalate on hepatic enzyme activities and lipid peroxidation in the rat

1987 • 77 citations

The role of trichloroacetic acid and peroxisome proliferation in the differences in carcinogenicity of perchloroethylene in the mouse and rat

1988 • 68 citations

Mitogenic stimulation of hepatocellular proliferation in rodents following 1,4-dichlorobenzene administration

1992 • 68 citations

Induction of cytochrome P-450 in cultured rat hepatocytes. The heterogeneous localization of specific isoenzymes using immunocytochemistry

1989 • 64 citations

Comparison of short-term renal effects due to oral administration of decalin or d-limonene in young adult male Fischer-344 rats

1987 • 59 citations

Suppression of hepatocyte apoptosis and induction of DNA synthesis by the rat and mouse hepatocarcinogen diethylhexylphlathate (DEHP) and the mouse hepatocarcinogen 1,4-dichlorobenzene (DCB)

1998 • 56 citations

Histopathology of Nasal Olfactory Mucosa from Selected Inhalation Toxicity Studies Conducted with Volatile Chemicals

1999 • 55 citations

α2U-Globulin: Measurement in rat kidney following administration of 2,2,4-trimethylpentane

1986 • 50 citations

Evidence that toxic injury is not always associated with induction of chemical carcinogenesis

1991 • 49 citations

The International Life Sciences Institute's Role in the Evaluation of Alternative Methodologies for the Assessment of Carcinogenic Risk

1998 • 42 citations

Image analysis of bromodeoxyuridine (BrdU) staining for measurement of S-phase in rat and mouse liver.

1994 • 34 citations

Comparison of the Hepatic and Renal Effects of 1,4-Dichlorobenzene in the Rat and Mouse

1997 • 33 citations

The role of cell proliferation in chemically induced carcinogenesis

1997 • 22 citations

Expectations for Transgenic Rodent Cancer Bioassay Models

2001 • 20 citations

Expression of the Immediate–Early Genes, c-fos,c-jun,and c-myc:A Comparison in Rats of Nongenotoxic Hepatocarcinogens with Noncarcinogenic Liver Mitogens

1997 • 19 citations

Measures of Cell Replication in Risk/Safety Assessment of Xenobiotic-Induced, Nongenotoxic Carcinogenesis

1996 • 18 citations

The evaluation of potential human carcinogens: A histopathologist's point of view

1996 • 15 citations

Time course of enzyme induction in liver and kidneys and absorption, distribution and elimination of 1,4-dichlorobenzene in rats

1998 • 10 citations

Preface

1996 • 8 citations

Cinnamyl Anthranilate Causes Coinduction of Hepatic Microsomal and Peroxisomal Enzymes in Mouse but Not Rat

1997 • 7 citations

Comparison of the Effects of Cinnamyl Anthranilate on Hepatic Peroxisome Proliferation and Cell Replication in the Rat and Mouse,

1997 • 5 citations

Validation of tests for carcinogenicity.

1980 • 4 citations