Responses of Transgenic Mouse Lines p53+/- and TgAC to Agents Tested in Conventional Carcinogenicity Bioassays

Spontaneous and carcinogen–induced tumorigenesis in p53–deficient mice

1993 • 537 citations

v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid.

1990 • 300 citations

Spontaneous Neoplasm Incidences in Fischer 344 Rats and B6C3F₁ Mice in Two-Year Carcinogenicity Studies: A National Toxicology Program Update

1998 • 283 citations

Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models.

1995 • 261 citations

Phenolphthalein Induces Thymic Lymphomas Accompanied by Loss of the p53 Wild Type Allele in Heterozygous p53-Deficient (±) Mice

1997 • 79 citations

The National Toxicology Program Evaluation of Genetically Altered Mice as Predictive Models for Identifying Carcinogens

1998 • 70 citations

Development of a transgenic mouse model for carcinogenesis bioassays: evaluation of chemically induced skin tumors in Tg.AC mice

1999 • 59 citations

Genetically altered mouse models for identifying carcinogens.

1999 • 57 citations

Kinetics of wound-induced v-Ha-ras transgene expression and papilloma development in transgenic Tg.AC mice

1997 • 51 citations

An Evaluation of the Hemizygous Transgenic Tg.AC Mouse for Carcinogenicity Testing of Pharmaceuticals. II. A Genotypic Marker that Predicts Tumorigenic Responsiveness

1998 • 47 citations

An Evaluation of the Hemizygous Transgenic Tg.AC Mouse for Carcinogenicity Testing of Pharmaceuticals. I. Evidence for a Confounding Nonresponder Phenotype

1998 • 28 citations

Identifying Potential Human Carcinogens—The Role of Genetically Altered Rodents

1997 • 9 citations