The role of trichloroacetic acid and peroxisome proliferation in the differences in carcinogenicity of perchloroethylene in the mouse and rat

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A SPECTROPHOTOMETRIC METHOD FOR MEASURING THE BREAKDOWN OF HYDROGEN PEROXIDE BY CATALASE

1952 • 6,430 citations

CORRELATED MORPHOMETRIC AND BIOCHEMICAL STUDIES ON THE LIVER CELL

1969 • 1,134 citations

Carcinogenesis by Hepatic Peroxisome Proliferators: Evaluation of the Risk of Hypolipidemic Drugs and Industrial Plasticizers to Humans

1983 • 890 citations

Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens

1980 • 854 citations

The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver

1987 • 277 citations

HEPATIC AND RENAL EFFECTS OF PEROXISOME PROLIFERATORS: BIOLOGICAL IMPLICATIONS*

1982 • 237 citations

Review of the hepatic response to hypolipidaemic drugs in rodents and assessment of its toxicological significance to man

1981 • 233 citations

Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxirane formation

1975 • 232 citations

Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues

1979 • 221 citations

Fatty acid oxidation by human liver peroxisomes

1979 • 197 citations

DISTRIBUTION OF PEROXISOMES (MICROBODIES) IN THE NEPHRON OF THE RAT

1969 • 172 citations

Species differences in response to trichloroethylene

1985 • 144 citations

Young Scientists Award Lecture 1984: Species Differences in Carcinogenicity and Peroxisome Proliferation due to Trichloroethylene: A Biochemical Human Hazard Assessment

1985 • 139 citations

The metabolism of 36Cl-labelled trichloroethylene and tetrachloroethylene in the rat

1963 • 134 citations

Chemical reactivity, metabolic oxirane formation and biological reactivity of chlorinated ethylenes in the isolated perfused rat liver preparation

1975 • 128 citations

Species differences in response to trichloroethylene

1985 • 127 citations

The pharmacokinetics and macromolecular interactions of perchloroethylene in mice and rats as related to oncogenicity

1980 • 120 citations

Biochemical, histological, and ultrastructural changes in rat and mouse liver following the administration of trichloroethylene: Possible relevance to species differences in hepatocarcinogenicity

1985 • 119 citations

Urinary excretion of total trichloro-compounds, trichloroethanol, and trichloroacetic acid as a measure of exposure to trichloroethylene and tetrachloroethylene

1972 • 117 citations

Chlorinated hydrocarbon-induced peroxisomal enzyme activity in relation to species and organ carcinogenicity

1987 • 109 citations

Kinetics of tetrachloroethylene in volunteers; influence of exposure concentration and work load

1979 • 91 citations

Alkylation of RNA by vinyl chloride metabolites in vitro and in vivo: Formation of 1-N6-etheno-adenosine

1977 • 78 citations

Carcinogenesis bioassay of trichloroethylene.

1976 • 76 citations

A comparative study of the excretion of Fujiwara reaction-positive substances in urine of humans and rodents given trichloro- or tetrachloro-derivatives of ethane and ethylene

1972 • 73 citations

Experimental human exposures to tetrachloroethylene vapor and elimination in breath after inhalation

1976 • 70 citations

Bioassay of tetrachloroethylene for possible carcinogenicity.

1977 • 69 citations

Urinary Metabolites of 14C-Tetrachloroethylene in Mice

1961 • 59 citations

Effects of vinylidene chloride on DNA synthesis and DNA repair in the rat and mouse: A comparative study with dimethylnitrosamine

1980 • 58 citations

Limited capacity of humans to metabolize tetrachloroethylene

1983 • 48 citations

Biological actions and interactions of tetrachloroethylene

1983 • 32 citations

Genetic and biochemical studies on perchloroethylene ‘in vitro’ and ‘in vivo’

1983 • 28 citations

Microbody (Peroxisome) proliferation in mouse kidney induced by methyl clofenapate

1975 • 22 citations

METABOLISM OF TETRACHLOROETHYLENE IN GUINEA PIGS

1976 • 3 citations

METABOLISM OF TETRACHLOROETHYLENE IN GUINEA PIGS

1976 • 2 citations