An NMR comparison of the changes produced by different guanosine 5'-triphosphate analogs in wild-type and oncogenic mutant p21ras

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.

1990 • 1,077 citations

Tightly regulated tac promoter vectors useful for the expression of unfused and fused proteins in Escherichia coli

1988 • 1,049 citations

Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic ras Proteins

1990 • 1,037 citations

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1989 • 881 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

ras GTPase activating protein: Signal transmitter and signal terminator

1989 • 621 citations

Biological properties of human c-Ha-ras1 genes mutated at codon 12

1984 • 586 citations

Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis

1990 • 489 citations

[3] Expression and nitrogen-15 labeling of proteins for proton and nitrogen-15 nuclear magnetic resonance

1989 • 455 citations

Kinetics of interaction of nucleotides with nucleotide-free H-ras p21

1990 • 410 citations

Three-dimensional structures of H-ras p21 mutants: Molecular basis for their inability to function as signal switch molecules

1990 • 395 citations

The structure of Ras protein: a model for a universal molecular switch

1991 • 310 citations

NMR sequential assignment of Escherichia coli thioredoxin utilizing random fractional deuteriation

1988 • 274 citations

Crystal structures at 2.2 Å resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP

1991 • 261 citations

A Cytosolic Protein Catalyzes the Release of GDP from p21 ^ras

1990 • 231 citations

Identification of a nucleotide exchange-promoting activity for p21ras.

1990 • 144 citations

A novel membrane factor stimulates guanine nucleotide exchange reaction of ras proteins

1990 • 119 citations

Spontaneous activation of a human proto-oncogene.

1983 • 114 citations

C-terminal Truncation of p21H Preserves Crucial Kinetic and Structural Properties

1989 • 112 citations

Crystal structure of an active form of RAS protein, a complex of a GTP analog and the HRAS p21 catalytic domain.

1990 • 112 citations

Biochemical and biological properties of the human N-ras p21 protein.

1987 • 106 citations

The Mechanism of Guanosine Nucleotide Hydrolysis by p21 c-Ha-ras

1989 • 91 citations

Nitrogen-15-labeled yeast tRNAPhe: double and two-dimensional heteronuclear NMR of guanosine and uracil ring NH groups

1984 • 78 citations

Interactions of tubulin with guanylyl-(beta-gamma-methylene)diphosphonate. Formation and assembly of a stoichiometric complex.

1990 • 74 citations

Activation of an N-ras gene in acute myeloblastic leukemia through somatic mutation in the first exon.

1985 • 50 citations

NMR study of the phosphoryl binding loop in purine nucleotide proteins: evidence for strong hydrogen bonding in human N-ras p21

1990 • 49 citations

GTP hydrolysis mechanisms in ras p21 and in the ras-GAP complex studied by fluorescence measurements on tryptophan mutants

1991 • 45 citations

Studies on the structure and mechanism of H-ras p21

1992 • 40 citations

Mechanism of adenylate kinase. Is there a relationship between local substrate dynamics, and local binding energy, and the catalytic mechanism?

1989 • 38 citations

NMR studies of the conformational change in human N-p21ras produced by replacement of bound GDP with the GTP analog GTP.gamma.S

1992 • 31 citations

Conformation change of effector-region residues in antiparallel β-sheet of human c-Ha-ras protein on GDP→GTPγS exchange: A two-dimensional NMR study

1989 • 30 citations

Identification of resonances from an oncogenic activating locus of human N-RAS-encoded p21 protein using isotope-edited NMR.

1989 • 30 citations

Nitrogen-15 and oxygen-17 NMR studies of the proton binding sites in imidodiphosphate, tetraethyl imidodiphosphate, and adenylyl imidodiphosphate

1983 • 26 citations

Structural and dynamic differences between normal and transforming N-ras gene products: a phosphorus-31 and isotope-edited proton NMR study

1989 • 20 citations

A1H-15N NM R study of human c-Ha-ras protein: Biosynthetic incorporation of15N-labeled amino acids

1992 • 18 citations

Graduate crisis looms in the 1990s

1988 • 4 citations