Role of Extracellular ATP and P1 and P2 Classes of Purinergic Receptors in T‐cell Development and Cytotoxic T Lymphocyte Effector Functions

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP

1994 • 1,039 citations

New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor

1994 • 924 citations

ATP receptor-mediated synaptic currents in the central nervous system

1992 • 814 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

Direct Association of Adenosine Deaminase with a T Cell Activation Antigen, CD26

1993 • 493 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy.

1994 • 410 citations

FK506 and cyclosporin, molecular probes for studying intracellular signal transduction

1993 • 389 citations

Cell-to-cell spread of calcium signals mediated by ATP receptors in mast cells

1992 • 373 citations

The multidrug resistance (mdr1) gene product functions as an ATP channel.

1993 • 372 citations

Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

1994 • 307 citations

Identification of mRNAs Associated with Programmed Cell Death in Immature Thymocytes

1991 • 286 citations

Identification of mRNAs associated with programmed cell death in immature thymocytes.

1991 • 242 citations

Review Lecture: Protein phosphorylation and hormone action

1988 • 237 citations

Receptors for adenine nucleotides and nucleosides: subclassification, distribution, and molecular characterization.

1994 • 235 citations

Analysis of CD36 Binding Domains: Ligand Specificity Controlled by Dephosphorylation of an Ectodomain

1993 • 219 citations

Ecto-ATPase activity in cytolytic T-lymphocytes. Protection from the cytolytic effects of extracellular ATP.

1990 • 198 citations

Extracellular ATP in T-lymphocyte activation: possible role in effector functions.

1990 • 196 citations

Cytotoxic T lymphocyte mediated lysis without release of serine esterase

1987 • 196 citations

Exocytosis of cytolytic granules may not be required for target cell lysis by cytotoxic T-lymphocytes

1987 • 174 citations

Extracellular ATP as a possible mediator of cell-mediated cytotoxicity

1990 • 120 citations

Locus of inhibitory action of cAMP-dependent protein kinase in the antigen receptor-triggered cytotoxic T lymphocyte activation pathway.

1988 • 92 citations

Permeabilization of transformed cells in culture by external ATP

1985 • 92 citations

Extracellular nucleotide catabolism in human B and T lymphocytes. The source of adenosine production.

1988 • 92 citations

Development of Gene Therapy for Immunodeficiency: Adenosine Deaminase Deficiency

1993 • 82 citations

Elimination of Ehrlich tumours by ATP-induced growth inhibition, glutathione depletion and X-rays

1995 • 76 citations

Growth inhibition of transformed mouse fibroblasts by adenine nucleotides occurs via generation of extracellular adenosine.

1988 • 72 citations

Differential expression of calmodulin-binding proteins in B, T lymphocytes and thymocytes

1987 • 70 citations

Comparative studies of the cytotoxic T lymphocyte-mediated cytotoxicity and of extracellular ATP-induced cell lysis. Different requirements in extracellular Mg2+ and pH.

1991 • 63 citations

Biochemical characterization of the inhibitory effect of CsA on cytolytic T lymphocyte effector functions.

1989 • 59 citations

A role for calcineurin in degranulation of murine cytotoxic T lymphocytes.

1993 • 47 citations

Inhibition of nerve growth factor‐induced neurite outgrowth of PC12 cells by a protein kinase inhibitor which does not permeate the cell membrane

1991 • 47 citations

Modulation of cytolytic T lymphocyte functions by an inhibitor of serine/threonine phosphatase, okadaic acid. Enhancement of cytolytic T lymphocyte-mediated cytotoxicity.

1991 • 34 citations

The dual role of the cAMP-dependent protein kinase C alpha subunit in T-cell receptor-triggered T-lymphocytes effector functions.

1992 • 32 citations

Negative modulation of human NK cell activity by purinoceptors

1992 • 18 citations

Adenosine Deaminase and Thymocyte Maturation

1991 • 13 citations

Possible Role of Extracellular ATP in Cell-Cell Interactions Leading to CTL-Mediated Cytotoxicity

1993 • 7 citations